Functional expression and pharmacological modulation of TRPM3 in human sensory neurons

Vangeel, Laura; Benoit, Melissa; Miron, Yannick; Miller, Paul E.; Clercq, Katrien De; Chaltin, Patrick; Verfaillie, Cathérine; Vriens, Joris; Voets, Thomas

doi:10.1111/bph.14994

Cited by 36 publications

(31 citation statements)

References 55 publications

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“…The roles of PregS as a regulator of TRPM3 channels in humans have been recently reported, demonstrating the expression of TRPM3 channels in human DRG where PregS also produces calcium influx through these ion channels [132], highlighting the relationship between this neurosteroid and TRPM3 channels in the nocifensive response.…”

Section: Trpm3 Is the Main Target For The Effects Of Pregsmentioning

confidence: 93%

Steroids and TRP Channels: A Close Relationship

Méndez-Reséndiz

Enciso-Pablo

González‐Ramírez

et al. 2020

IJMS

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Transient receptor potential (TRP) channels are remarkable transmembrane protein complexes that are essential for the physiology of the tissues in which they are expressed. They function as non-selective cation channels allowing for the signal transduction of several chemical, physical and thermal stimuli and modifying cell function. These channels play pivotal roles in the nervous and reproductive systems, kidney, pancreas, lung, bone, intestine, among others. TRP channels are finely modulated by different mechanisms: regulation of their function and/or by control of their expression or cellular/subcellular localization. These mechanisms are subject to being affected by several endogenously-produced compounds, some of which are of a lipidic nature such as steroids. Fascinatingly, steroids and TRP channels closely interplay to modulate several physiological events. Certain TRP channels are affected by the typical genomic long-term effects of steroids but others are also targets for non-genomic actions of some steroids that act as direct ligands of these receptors, as will be reviewed here.

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Section: Trpm3 Is the Main Target For The Effects Of Pregsmentioning

confidence: 93%

Steroids and TRP Channels: A Close Relationship

Méndez-Reséndiz

Enciso-Pablo

González‐Ramírez

et al. 2020

IJMS

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“…TRPM3 is widely expressed in both neuronal and non-neuronal tissue, such as in brain and spinal tissues, retinal (53), pituitary, kidney, and testes (49). Through in situ hybridization and RT-qPCR of TRPM3 mRNA, studies have shown abundant expression in both TG and DRG sensory neurons ( Figure 1) (54). A large majority of TRPM3-expressing neurons are also responsive to capsaicin, demonstrating that it is often co-expressed with TRPV1.…”

Section: Trpm3mentioning

confidence: 99%

Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation

et al. 2020

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Transient receptor potential (TRP) channels are a superfamily of non-selective cation channels that act as polymodal sensors in many tissues throughout mammalian organisms. In the context of ion channels, they are unique for their broad diversity of activation mechanisms and their cation selectivity. TRP channels are involved in a diverse range of physiological processes including chemical sensing, nociception, and mediating cytokine release. They also play an important role in the regulation of inflammation through sensory function and the release of neuropeptides. In this review, we discuss the functional contribution of a subset of TRP channels (TRPV1, TRPV4, TRPM3, TRPM8, and TRPA1) that are involved in the body's immune responses, particularly in relation to inflammation. We focus on these five TRP channels because, in addition to being expressed in many somatic cell types, these channels are also expressed on peripheral ganglia and nerves that innervate visceral organs and tissues throughout the body. Activation of these neural TRP channels enables crosstalk between neurons, immune cells, and epithelial cells to regulate a wide range of inflammatory actions. TRP channels act either through direct effects on cation levels or through indirect modulation of intracellular pathways to trigger pro-or antiinflammatory mechanisms, depending on the inflammatory disease context. The expression of TRP channels on both neural and immune cells has made them an attractive drug target in diseases involving inflammation. Future work in this domain will likely yield important new pathways and therapies for the treatment of a broad range of disorders including colitis, dermatitis, sepsis, asthma, and pain.

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“…In addition, TRPM3 is upregulated in inflammatory conditions, which increases the overlap with and the interaction with signaling of TRPV1 and TRPA1 [211]. TRPM3 is found in human sensory neurons [212], and concentrations of volatile anesthetics not exceeding the minimal alveolar concentration by far can act as TRPM3 antagonists [213].…”

Section: Trp Channelsmentioning

confidence: 99%

Novel Analgesics with Peripheral Targets

Ciotu

Fischer

2020

Neurotherapeutics

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A limited number of peripheral targets generate pain. Inflammatory mediators can sensitize these. The review addresses targets acting exclusively or predominantly on sensory neurons, mediators involved in inflammation targeting sensory neurons, and mediators involved in a more general inflammatory process, of which an analgesic effect secondary to an anti-inflammatory effect can be expected. Different approaches to address these systems are discussed, including scavenging proinflammatory mediators, applying anti-inflammatory mediators, and inhibiting proinflammatory or facilitating anti-inflammatory receptors. New approaches are contrasted to established ones; the current stage of progress is mentioned, in particular considering whether there is data from a molecular and cellular level, from animals, or from human trials, including an early stage after a market release. An overview of publication activity is presented, considering a IuPhar/BPS-curated list of targets with restriction to pain-related publications, which was also used to identify topics.

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Functional expression and pharmacological modulation of TRPM3 in human sensory neurons

Cited by 36 publications

References 55 publications

Steroids and TRP Channels: A Close Relationship

Steroids and TRP Channels: A Close Relationship

Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation

Novel Analgesics with Peripheral Targets

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