Functional Extracellular Vesicles for Regenerative Medicine

Kim, Han Young; Kwon, Seunglee; Um, Wooram; Shin, Sol; Kim, Chan Ho; Park, Jae Hyung; Kim, Byung Soo

doi:10.1002/smll.202106569

Cited by 41 publications

(32 citation statements)

References 180 publications

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“…Similarly, priming MSCs derived from adipose tissue with TNF-a results in EV secretion and osteogenic differentiation of human primary osteoblasts ( Davies et al, 2017 ; Lu et al, 2017 ; Lee and Kim, 2021 ; Liu and Holmes, 2021 ; Nagelkerke et al, 2021 ). EVs can also be bioengineered and enriched with favourable factors such as drugs and growth factors to serve as targeted therapies ( Kim et al, 2022 ). All of these demonstrate the huge potential of EVs for tissue regeneration.…”

Section: Regenerative Potential Of Extracellular Spacementioning

confidence: 99%

“…To bypass some of the limitations of natural occurring EVs and avoid some of the mentioned inconsistencies, EVs can be bioengineered and enriched with favourable factors resulting in enhanced yield and better isolation but the full impact of these modifications on target cells needs to be investigated in detail ( Kim et al, 2022 ). In clinical translation, it is yet to be determined which donor cell source can provide the most potent EV subtypes and which factors influence this ( Beer et al, 2017 ).…”

Section: Challenges In Secretome Therapy For Tissue Regenerationmentioning

confidence: 99%

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Potential of extracellular space for tissue regeneration in dentistry

Birjandi

Sharpe

2022

Front. Physiol.

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With the proven relationship between oral and general health and the growing aging population, it is pivotal to provide accessible therapeutic approaches to regenerate oral tissues and restore clinical function. However, despite sharing many core concepts with medicine, dentistry has fallen behind the progress in precision medicine and regenerative treatments. Stem cell therapies are a promising avenue for tissue regeneration, however, ethical, safety and cost issues may limit their clinical use. With the significance of paracrine signalling in stem cell and tissue regeneration, extracellular space comprising of the cell secretome, and the extracellular matrix can serve as a potent source for tissue regeneration. Extravesicles are secreted and naturally occurring vesicles with biologically active cargo that can be harvested from the extracellular space. These vesicles have shown great potential as disease biomarkers and can be used in regenerative medicine. As a cell free therapy, secretome and extracellular vesicles can be stored and transferred easily and pose less ethical and safety risks in clinical application. Since there are currently many reviews on the secretome and the biogenesis, characterization and function of extracellular vesicles, here we look at the therapeutic potential of extracellular space to drive oral tissue regeneration and the current state of the field in comparison to regenerative medicine.

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Section: Regenerative Potential Of Extracellular Spacementioning

confidence: 99%

Section: Challenges In Secretome Therapy For Tissue Regenerationmentioning

confidence: 99%

Potential of extracellular space for tissue regeneration in dentistry

Birjandi

Sharpe

2022

Front. Physiol.

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“…Extracellular vesicles (EVs), which are nano- to micro-sized lipid bilayer membrane particles secreted by host cells, play critical roles in novel intercellular communication mechanisms, mediating the transduction of functional molecules with physiological activity, such as microRNAs, mRNAs, proteins, and lipids ( Figure 1 ) [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ,…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine

Matsuzaka

Yashiro

2022

IJMS

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Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in intracellular communication through EV-encapsulated informative content, including proteins, lipids, and nucleic acids. Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal ability derived from bone marrow, fat, umbilical cord, menstruation blood, pulp, etc., which they use to induce tissue regeneration by their direct recruitment into injured tissues, including the heart, liver, lung, kidney, etc., or secreting factors, such as vascular endothelial growth factor or insulin-like growth factor. Recently, MSC-derived EVs have been shown to have regenerative effects against various diseases, partially due to the post-transcriptional regulation of target genes by miRNAs. Furthermore, EVs have garnered attention as novel drug delivery systems, because they can specially encapsulate various target molecules. In this review, we summarize the regenerative effects and molecular mechanisms of MSC-derived EVs.

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“…Accumulating studies have suggested that EVs represent a new manner of intercellular communication and contribute to the regulation of many pathophysiological processes [ 19 , 20 ]. In addition, the lipid bilayer membrane structure endows EVs with great stability in circulation and protects their cargo from degradation [ 21 ]. Recently, the cell-free strategy based on MSC-derived EVs (MSC-EVs) for tissue regeneration has attracted considerable attention.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Potential Therapy for Diabetes Mellitus and Diabetic Complications

Sun

et al. 2022

Pharmaceutics

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As a novel cell-free strategy, mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) inherit the therapeutic potential of donor cells, and are widely used for the treatment of many diseases. Increasing studies have shown that MSC-EVs transfer various bioactive molecules to create a beneficial microenvironment, thus exerting protective roles in diabetic mellitus (DM) and diabetic complications. To overcome the limitations of natural MSC-EVs such as heterogeneity and insufficient function, several modification methods have been established for constructing engineered MSC-EVs with elevated repairing efficiency. In this review, the PubMed library was searched from inception to August 2022, using a combination of Medical Subject Headings (MeSH) and keywords related to MSC-EVs, DM, and diabetic complications. We provide an overview of the major characteristics of MSC-EVs and summarize the recent advances of MSC-EV-based therapy for hyperglycemia-induced tissue damage with an emphasis on MSC-EV-mediated delivery of functional components. Moreover, the potential applications of engineered MSC-EVs in DM-related diseases therapy are discussed by presenting examples, and the opportunities and challenges for the clinical translation of MSC-EVs, especially engineered MSC-EVs, are evaluated.

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Functional Extracellular Vesicles for Regenerative Medicine

Cited by 41 publications

References 180 publications

Potential of extracellular space for tissue regeneration in dentistry

Potential of extracellular space for tissue regeneration in dentistry

Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine

Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Potential Therapy for Diabetes Mellitus and Diabetic Complications

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