2009
DOI: 10.1128/jb.01688-08
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Functional Genomics ofEnterococcus faecalis: Multiple Novel Genetic Determinants for Biofilm Formation in the Core Genome

Abstract: The ability of Enterococcus faecalis to form robust biofilms on host tissues and on abiotic surfaces such as catheters likely plays a major role in the pathogenesis of opportunistic antibiotic-resistant E. faecalis infections and in the transfer of antibiotic resistance genes. We have carried out a comprehensive analysis of genetic determinants of biofilm formation in the core genome of E. faecalis. Here we describe 68 genetic loci predicted to be involved in biofilm formation that were identified by recombina… Show more

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Cited by 57 publications
(73 citation statements)
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“…To test the hypothesis that enterococcal biofilm determinants are virulence factors in endocarditis, we chose seven loci (Table 1) in the chromosome of E. faecalis OG1RF that were associated with biofilm formation in our previous studies (20,25). The following five loci were disrupted with transposon insertions: EF0676, EF0799, EF0983, EF0999, and EF1718.…”
Section: Resultsmentioning
confidence: 99%
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“…To test the hypothesis that enterococcal biofilm determinants are virulence factors in endocarditis, we chose seven loci (Table 1) in the chromosome of E. faecalis OG1RF that were associated with biofilm formation in our previous studies (20,25). The following five loci were disrupted with transposon insertions: EF0676, EF0799, EF0983, EF0999, and EF1718.…”
Section: Resultsmentioning
confidence: 99%
“…The in-frame markerless deletion of the recN (EF0984) locus was previously described in an OG1RF(pCF10) strain (25). The same constructs and procedures were used in this study to generate a pCF10-free version of OG1RF ⌬recN.…”
Section: Methodsmentioning
confidence: 99%
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