Functional Hydrogel Co‐Remolding Migration and Differentiation Microenvironment for Severe Spinal Cord Injury Repair
Dingyang Liu,
He Shen,
Kai Zhang
et al.
Abstract:Spinal cord injury (SCI) activates nestin+ neural stem cells (NSCs), which can be regarded as potential seed cells for neuronal regeneration. However, the lesion microenvironment seriously hinders the migration of the nestin+ cells to the lesion epicenter and their differentiation into neurons to rebuild neural circuits. In this study, a photosensitive hydrogel scaffold is prepared as drug delivery carrier. Genetically engineered SDF1α and NT3 are designed and the scaffold is binary modified to reshape the les… Show more
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