Functional Imaging: CT and MRI

Beek, Edwin Jacques Rudolph van; Hoffman, Eric A.

doi:10.1016/j.ccm.2007.12.003

Cited by 81 publications

(52 citation statements)

References 193 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HRCT imaging detects early emphysema by identifying pulmonary tissue with radiologic attenuation below a predetermined threshold, findings that roughly correlate with a low DL CO and pathologic evidence of emphysema (74)(75)(76)(77)(78)(79)(80). Although several studies have shown that a significant proportion of asymptomatic smokers have HRCT evidence of emphysema (78,(81)(82)(83), early HRCT findings of ''emphysema'' are not proven to be correlated directly with lung destruction (84)(85)(86)(87)(88)(89)(90).…”

Section: Early Detection Of Lung Destructionmentioning

confidence: 99%

Circulating Endothelial Microparticles as a Measure of Early Lung Destruction in Cigarette Smokers

Gordon

Gudi

Krause

et al. 2011

Am J Respir Crit Care Med

205

173

View full text Add to dashboard Cite

Rationale: There is increasing evidence that emphysema is associated with primary loss of pulmonary capillary endothelium. Plasma levels of endothelial microparticles (EMPs), small vesicles released from activated or apoptotic endothelial cells, are elevated in vascularrelated disorders. Objectives: To evaluate whether plasma EMP levels are elevated in smokers with early lung destruction as assessed by normal spirometry but reduced diffusing capacity of the lung for carbon monoxide (DL CO ). Methods: Lung health was assessed by pulmonary function tests (PFTs: spirometry, total lung capacity, DL CO ) and chest X-ray; smoking status was assessed by urine nicotine and cotinine. EMP levels (CD42b 2 CD31 1 microparticles) were quantified as activated or apoptotic. The initial cohort (n 5 92) included healthy nonsmokers (normal PFTs), healthy smokers (normal PFTs), and smokers with early evidence of lung destruction (normal spirometry, low DL CO ). Two prospective cohorts were then tested: a group similar to the initial cohort and an HIV1 1 cohort. Measurements and Main Results: Healthy smokers had mildly increased levels of EMPs. Strikingly, 95% of smokers with normal spirometry, low DL CO had increased EMPs, with reduced CD62 1 / CD31 1 ratios (P , 10 24 ) and elevated CD42b 2 CD31 1 annexin V 1 EMPs (P , 10 24 ), suggesting derivation from endothelial apoptosis. Most elevated EMPs were angiotensin-converting enzyme positive, suggesting derivation from pulmonary capillaries. Both prospective cohorts confirmed the initial cohort data. Conclusions: Plasma EMPs with apoptotic characteristics are elevated in smokers with normal spirometry but reduced DL CO , consistent with the concept that emphysema is associated, in part, with capillary endothelium apoptosis, suggesting that the early development of emphysema might be monitored with plasma EMP levels.

show abstract

Section: Early Detection Of Lung Destructionmentioning

confidence: 99%

Circulating Endothelial Microparticles as a Measure of Early Lung Destruction in Cigarette Smokers

Gordon

Gudi

Krause

et al. 2011

Am J Respir Crit Care Med

205

173

View full text Add to dashboard Cite

show abstract

“…Imaging techniques used in the diagnosis of sarcoidosis include CT (in the case of pulmonary sarcoidosis, HRCT: high resolution computerised tomography), MRI [magnetic resonance imaging (with gadolinium contrast)] and FDG-PET (positron emission tomography with Xuoro-2-deoxy-D-glucose) [61][62][63]. Imaging examinations via 67-radiogallium citrate scintigraphy is also used for the diagnosis of sarcoidosis [1][2][3][4][5][6][7][8]44].…”

Section: Diagnosismentioning

confidence: 99%

Sarcoidosis and its otolaryngological implications

Mrówka-Kata¹,

Kata

Lange

et al. 2010

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…To estimate lung perfusion, various approaches for determining blood flow and mean transit time have been described using dynamic CT (52,53). The main focus thus far has been related to the visualization of perfusion defects in pulmonary embolism or the characterization of lung tumors.…”

Section: Functional Imagingmentioning

confidence: 99%

Imaging phenotypes of chronic obstructive pulmonary disease

Ley‐Zaporozhan¹,

Beek²

2010

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a heterogeneous disease affecting the airways and/or the parenchyma with different severity during the course of the disease. These different aspects of COPD can be addressed by imaging using a combination of morphological and functional techniques. Computed tomography (CT) is the technique of choice for morphological imaging of the lung parenchyma and airways. This morphological information is to be accomplished by functional information about ventilation and perfusion, mainly provided by magnetic resonance imaging (MRI). The comprehensive diagnostic possibilities of CT complemented by MRI will allow for a more sensitive detection, phenotype-driven characterization, and dedicated therapy monitoring of the disease.

show abstract

Functional Imaging: CT and MRI

Cited by 81 publications

References 193 publications

Circulating Endothelial Microparticles as a Measure of Early Lung Destruction in Cigarette Smokers

Circulating Endothelial Microparticles as a Measure of Early Lung Destruction in Cigarette Smokers

Sarcoidosis and its otolaryngological implications

Imaging phenotypes of chronic obstructive pulmonary disease

Contact Info

Product

Resources

About