Functional imaging in head and neck squamous cell carcinoma: correlation of PET/CT and diffusion-weighted imaging at 3 Tesla

Abstract

There is no correlation between the FDG uptake and the ADC value in head and neck SCC. The three different tumour grades and four tumour stages present in our study population could not be differentiated based on ADC values or SUV.

Assessment of serial multi-parametric functional MRI (diffusion-weighted imaging andR2*) with18F-FDG-PET in patients with head and neck cancer treated with radiation therapy

“…This improves image quality and makes identification of ROIs easier. Registration accuracy was not investigated in this study, and although our method aimed at minimizing the error and is consistent with other published studies correlating MRI and 18 F-FDG-PET studies in HNC, 21,23 this should be addressed in the future.…”

Feasibility of Multiparametric Imaging with PET/MR in Head and Neck Squamous Cell Carcinoma

“…This study also reported a negative correlation, however, the study included only 7 patients with different tumor subsites (6). The existing studies in the literature either are not performed on an integrated PET/MR scanner or do not include patients with head and neck tumors (21,22,(34)(35)(36)(37)(38). The nonsignificant correlation found across patients suggests that information on glucose metabolism and cellularity from only 1 voxel, the voxel within the tumor either with the highest 18 F-FDG uptake (SUV max ) or with the lowest diffusion (ADC min ), may be too crude to adequately describe the tumor and depict a potential correlation.…”

Differentiation between Graves' disease and painless thyroiditis by diffusion-weighted imaging, thyroid iodine uptake, thyroid scintigraphy and serum parameters

“…Studies have also demonstrated that, for malignancy imaging, the quantitative analysis of ADC and the standard uptake value (SUV) in fluorodeoxyglucose positron emission tomography (FDG PET)/CT are inversely correlated (37)(38)(39)(40)(41)(42). ADC and SUV play complementary roles in the provision of functional information concerning cancer, which can now be successfully applied in head and neck cancers, after overcoming the motion artifacts from swallowing or respiration and susceptibility artifacts due to air/soft tissue/ bone interfaces (38)(39)(40). FDG PET/CT traces glucose metabolism, a nonspecific process essential for tumor growth.…”

“…It has primarily been used clinically for brain disorders, particularly for the early detection of ischemic stroke or infarction (33)(34)(35)(36). Numerous studies have put forward DWI as a new and valuable cancer imaging biomarker for detection, diagnosis, staging, detecting metastasis or relapse, and assessing treatment response (30)(31)(32)(37)(38)(39)(40)(41)(42)(43)(44). Studies have also demonstrated that, for malignancy imaging, the quantitative analysis of ADC and the standard uptake value (SUV) in fluorodeoxyglucose positron emission tomography (FDG PET)/CT are inversely correlated (37)(38)(39)(40)(41)(42).…”

“…Numerous studies have put forward DWI as a new and valuable cancer imaging biomarker for detection, diagnosis, staging, detecting metastasis or relapse, and assessing treatment response (30)(31)(32)(37)(38)(39)(40)(41)(42)(43)(44). Studies have also demonstrated that, for malignancy imaging, the quantitative analysis of ADC and the standard uptake value (SUV) in fluorodeoxyglucose positron emission tomography (FDG PET)/CT are inversely correlated (37)(38)(39)(40)(41)(42). ADC and SUV play complementary roles in the provision of functional information concerning cancer, which can now be successfully applied in head and neck cancers, after overcoming the motion artifacts from swallowing or respiration and susceptibility artifacts due to air/soft tissue/ bone interfaces (38)(39)(40).…”