Functional imaging of brain responses to pain. A review and meta-analysis (2000)

Peyron, R.; Laurent, Bernard; García-Larrea, L.

doi:10.1016/s0987-7053(00)00227-6

Cited by 1,978 publications

(1,562 citation statements)

References 145 publications

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“…Regions including the bilateral insular cortices, the anterior cingulate cortex, the cerebellum, the bilateral secondary sensory region (SII) and the bilateral thalamus were active at this statistical level (Z44.0 and activated cluster significance Po0.01). This pattern of activity is consistent with previous reports of thermal pain-related brain activity (Becerra et al, 1999;Jones et al, 1991a;Peyron et al, 2000;Talbot et al, 1991;Tracey et al, 2000a). The right-sided insular cortex (contralateral to the stimulus), defined from the MNI standard brain, was chosen for further time-series analysis.…”

Section: Pain-related Brain Activitysupporting

confidence: 80%

“…fMRI of the time dependence of remifentanil analgesia RG Wise et al Of the regions listed, this region shows significant modulation of pain-related activity resulting from remifentanil infusion (Tracey, 2001;Wise et al, 2002), and is observed to be one of the most robustly pain-active regions (Peyron et al, 2000). These factors would suggest that, given the limited signal-to-noise ratio of drug-induced changes in the fMRI signal, the likelihood of extracting meaningful pharmacokinetic data on drug effect was highest for this chosen region of interest.…”

Section: Pain-related Brain Activitymentioning

confidence: 99%

“…However, PET is restricted as a tool for examining task-related brain activity by its relatively long measurement time and invasiveness. fMRI, however, noninvasively provides better spatial and temporal localization of brain activity during complex event-related tasks such as thermal pain (Peyron et al, 2000) that may be modulated by analgesic drugs including opioids (Tracey et al, 2000b;Tracey, 2001). We have previously identified from fMRI signal, remifentanil-induced regional modulation of pain-related brain activity (Wise et al, 2002) with the help of a model for drug effect site concentration based on EEG measurements (Minto et al, 1997a, b).…”

Section: Introductionmentioning

confidence: 99%

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Using fMRI to Quantify the Time Dependence of Remifentanil Analgesia in the Human Brain

Wise

Williams

Tracey

2003

Neuropsychopharmacol

108

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To understand and exploit centrally acting drugs requires reliable measures of their time course of action in the human brain. Functional magnetic resonance imaging (fMRI) is able to measure noninvasively, drug-induced changes in task-related brain activity. Here, we have characterized, in a specific region of the brain, the time of onset of action and the half-life of action of a clinically relevant dose of a potent opioid analgesic agent, remifentanil. These times were established from the temporal variation of the amplitude of the blood oxygen level-dependent response in the insular cortex contralateral to a painfully hot thermal stimulus, in volunteers receiving a remifentanil infusion. The insular cortex has repeatedly been reported as activated by noxious thermal stimulation. The times of onset and offset of drug action were each characterized by a half-life for changes in fMRI signal from within the insula. These characteristic times agreed with the observed drug-induced analgesia and previous pharmacokinetic-pharmacodynamic measurements for remifentanil. We have successfully measured, for the first time using fMRI, temporal pharmacological parameters for a CNS-active drug based on its effect on task-related activity in a specific brain region. Comparison of the time course of regional brain activity with pain perception could reveal those regions engaged in drug-induced analgesia.

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Section: Pain-related Brain Activitysupporting

confidence: 80%

Section: Pain-related Brain Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Using fMRI to Quantify the Time Dependence of Remifentanil Analgesia in the Human Brain

Wise

Williams

Tracey

2003

Neuropsychopharmacol

108

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“…To examine pain-related neural activity, we examined: a) whether each group showed neural activity in three regions previously linked to pain processes (anterior cingulate cortex (ACC), insula, periaqueductal gray (PAG) (Peyron, Laurent & Garcia-Larrea, 2000); and b) whether there were significant differences between the groups in pain-related neural activity in those regions (p < .005, 10 voxels). If one group showed significant activation in a region (p< .005, 10 voxels), we reported the activation from that same coordinate in the other group (Table 1).…”

Section: Pain Network Activationmentioning

confidence: 99%

Craving love? Enduring grief activates brain's reward center

et al. 2008

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Complicated grief (CG) occurs when an individual experiences prolonged, unabated grief. The neural mechanisms distinguishing CG from noncomplicated grief (NCG) are unclear, but hypothesized mechanisms include both pain-related activity (related to the social pain of loss) and reward-related activity (related to attachment behavior). Bereaved women (11 CG, 12 NCG) participated in an eventrelated functional magnetic resonance imaging scan, during grief elicitation with idiographic stimuli. Analyses revealed that whereas both CG and NCG participants showed pain-related neural activity in response to reminders of the deceased, only those with CG showed reward-related activity in the nucleus accumbens (NA). This NA cluster was positively correlated with self-reported yearning, but not with time since death, participant age, or positive/negative affect. This study supports the hypothesis that attachment activates reward pathways. For those with CG, reminders of the deceased still activate neural reward activity, which may interfere with adapting to the loss in the present.

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“…A wealth of electrophysiological, anatomical, and radiological evidence in humans and animals, reviewed elsewhere, establishes both PAG and VP as structures important to pain perception and the pathophysiology of chronic pain syndromes [86][87][88][89][90][91][92][93][94]. The subtleties of hierarchical position and the behavioral function of individual brain structures, whether sensory-discriminative, attentional, motivational-affective, or hedonic, are much debated.…”

Section: Physiologymentioning

confidence: 99%

Neuropathic Pain and Deep Brain Stimulation

Pereira

Aziz

2014

Neurotherapeutics

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Deep brain stimulation (DBS) is a neurosurgical intervention the efficacy, safety, and utility of which are established in the treatment of Parkinson's disease. For the treatment of chronic, neuropathic pain refractory to medical therapies, many prospective case series have been reported, but few have published findings from patients treated with current standards of neuroimaging and stimulator technology over the last decade . We summarize the history, science, selection, assessment, surgery, programming, and personal clinical experience of DBS of the ventral posterior thalamus, periventricular/periaqueductal gray matter, and latterly rostral anterior cingulate cortex (Cg24) in 113 patients treated at 2 centers (John Radcliffe, Oxford, UK, and Hospital de São João, Porto, Portugal) over 13 years. Several experienced centers continue DBS for chronic pain, with success in selected patients, in particular those with pain after amputation, brachial plexus injury, stroke, and cephalalgias including anesthesia dolorosa. Other successes include pain after multiple sclerosis and spine injury. Somatotopic coverage during awake surgery is important in our technique, with cingulate DBS under general anesthesia considered for whole or hemibody pain, or after unsuccessful DBS of other targets. Findings discussed from neuroimaging modalities, invasive neurophysiological insights from local field potential recording, and autonomic assessments may translate into improved patient selection and enhanced efficacy, encouraging larger clinical trials.

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Functional imaging of brain responses to pain. A review and meta-analysis (2000)

Cited by 1,978 publications

References 145 publications

Using fMRI to Quantify the Time Dependence of Remifentanil Analgesia in the Human Brain

Using fMRI to Quantify the Time Dependence of Remifentanil Analgesia in the Human Brain

Craving love? Enduring grief activates brain's reward center

Neuropathic Pain and Deep Brain Stimulation

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