Functional Magnetic Resonance Imaging of Methylphenidate and Placebo in Attention-Deficit/Hyperactivity Disorder During the Multi-Source Interference Task

Bush, George; Spencer, Thomas; Holmes, Jennifer; Shin, Lisa M.; Valera, Eve M.; Seidman, Larry J.; Makris, Nikos; Surman, Craig; Aleardi, Megan; Mick, Eric; Biederman, Joseph

doi:10.1001/archgenpsychiatry.2007.16

Cited by 177 publications

(165 citation statements)

References 117 publications

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“…Second, a single dose of MPH increased the right frontal NIRS signal (Figure 4b), thus confirming that MPH increased RIFC activation during an inhibitory control task (Rubia et al, 2014). Third, the change toward a level of prefrontal activation similar to that for HCs after the 4-to-8-week open trial (Figure 4c) is consistent with the results from a fMRI study of adults with ADHD (Bush et al, 2008) and an ERP study in children with ADHD (Sawada et al, 2010). Finally, our finding (Figure 4d) that long-term (1 year) MPH treatment affected brain development in ADHD children is consistent with the findings of a prospective MRI study (Konrad et al, 2007).…”

Section: Discussionsupporting

confidence: 84%

“…Increases in LIFC activity were previously observed in patients with ADHD who performed an error-monitoring task after acute (Rubia et al, 2011) and 6 weeks-MPH treatment during interference inhibition (Bush et al, 2008). A change in activation in the single-dose trial toward the level in HCs indicated a better response to continuous administration of MPH.…”

Section: Discussionmentioning

confidence: 56%

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Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial

Ishii-Takahashi

Takizawa

Nishimura

et al. 2015

Neuropsychopharmacol

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Although methylphenidate hydrochloride (MPH) is a first-line treatment for children with attention-deficit hyperactivity disorder (ADHD), the non-response rate is 30%. Our aim was to develop a supplementary neuroimaging biomarker for predicting the clinical effect of continuous MPH administration by using near-infrared spectroscopy (NIRS). After baseline assessment, we performed a double-blind, placebo-controlled, crossover trial with a single dose of MPH, followed by a prospective 4-to-8-week open trial with continuous MPH administration, and an ancillary 1-year follow-up. Twenty-two drug-naïve and eight previously treated children with ADHD (NAÏVE and NON-NAÏVE) were compared with 20 healthy controls (HCs) who underwent multiple NIRS measurements without intervention. We tested whether NIRS signals at the baseline assessment or ΔNIRS (single dose of MPH minus baseline assessment) predict the Clinical Global Impressions-Severity (CGI-S) score after 4-to-8-week or 1-year MPH administration. The secondary outcomes were the effect of MPH on NIRS signals after single-dose, 4-to-8-week, and 1-year administration. ΔNIRS significantly predicted CGI-S after 4-to-8-week MPH administration. The leave-one-out classification algorithm had 81% accuracy using the NIRS signal. ΔNIRS also significantly predicted CGI-S scores after 1 year of MPH administration. For secondary analyses, NAÏVE exhibited significantly lower prefrontal activation than HCs at the baseline assessment, whereas NON-NAÏVE and HCs showed similar activation. A single dose of MPH significantly increased activation compared with the placebo in NAÏVE. After 4-to-8-week administration, and even after MPH washout following 1-year administration, NAÏVE demonstrated normalized prefrontal activation. Supplementary NIRS measurements may serve as an objective biomarker for clinical decisions and monitoring concerning continuous MPH treatment in children with ADHD.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 56%

Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial

Ishii-Takahashi

Takizawa

Nishimura

et al. 2015

Neuropsychopharmacol

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“…The daMCC, located on the medial surface of the frontal lobe, refers to areas 24c 0 /32 0 in humans. The nomenclature of cingulate subdivisions has evolved over the past few decades (Bush, 2009;Bush et al, 2008;Vogt, 2005): for simplicity here, the daMCC is equivalent to the dorsal ACC (Bush and Shin, 2006;Bush et al, 2002) and broadly consistent with the older term, the ACC, used by studies above (Alexander et al, 1986;Posner and Petersen, 1990). The daMCC maintains strong reciprocal connections with other cognitive/attention and motor regions, including the DLPFC, parietal cortex, premotor cortex, and striatum.…”

Section: Cfp Attention Networkmentioning

confidence: 93%

“…Moreover, a metaanalysis of neuroimaging studies by Dickstein et al (2006) found the daMCC among a short list of brain regions that were hypoactive in ADHD patients relative to healthy controls. Recently, Bush et al (2008) used fMRI to show that 6 weeks of MPH significantly increased daMCC activation, as compared with placebo, in adults with ADHD. Similarly, an ERP study reported that stimulant treatment increased ACC activity .…”

Section: Functional Studies: Pet and Fmrimentioning

confidence: 99%

Attention-Deficit/Hyperactivity Disorder and Attention Networks

Bush

2009

Neuropsychopharmacol

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301

251

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Research attempting to elucidate the neuropathophysiology of attention-deficit/hyperactivity disorder (ADHD) has not only shed light on the disorder itself, it has simultaneously provided new insights into the mechanisms of normal cognition and attention. This review will highlight and integrate this bidirectional flow of information. Following a brief overview of ADHD clinical phenomenology, ADHD studies will be placed into a wider historical perspective by providing illustrative examples of how major models of attention have influenced the development of neurocircuitry models of ADHD. The review will then identify major components of neural systems potentially relevant to ADHD, including attention networks, reward/feedbackbased processing systems, as well as a 'default mode' resting state network. Further, it will suggest ways in which these systems may interact and be influenced by neuromodulatory factors. Recent ADHD imaging data will be selectively provided to both illustrate the field's current level of knowledge and to show how such data can inform our understanding of normal brain functions. The review will conclude by suggesting possible avenues for future research.

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“…Our results are in partial agreement with data observed from a research performed with MSIT evaluated by means with functional magnetic resonance imaging. Children with ADHD, showed lower CFPCAN activation than controls 16 . Comparison must be made with careful, because technique differences between studies.…”

Section: Ern Usefulnessmentioning

confidence: 79%

Error related negativity and multi-source interference task in children with attention deficit hyperactivity disorder-combined type

Huerta-Albarrán

Poblano

Santana-Vargas

et al. 2015

Arq. Neuro-Psiquiatr.

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Objective: To compare performance of children with attention deficit hyperactivity disorders-combined (ADHD-C) type with control children in multi-source interference task (MSIT) evaluated by means of error related negativity (ERN). Method: We studied 12 children with ADHD-C type with a median age of 7 years, control children were age-and gender-matched. Children performed MSIT and simultaneous recording of ERN. Results: We found no differences in MSIT parameters among groups. We found no differences in ERN variables between groups. We found a significant association of ERN amplitude with MSIT in children with ADHD-C type. Some correlation went in positive direction (frequency of hits and MSIT amplitude), and others in negative direction (frequency of errors and RT in MSIT). Conclusion: Children with ADHD-C type exhibited a significant association between ERN amplitude with MSIT. These results underline participation of a cingulofronto-parietal network and could help in the comprehension of pathophysiological mechanisms of ADHD.Keywords: attention deficit hyperactivity disorder, multi-source interference task, event related potentials, error-related negativity, cingulo-fronto-parietal network. RESUMENObjetivo: Comparar el rendimiento de un grupo de niños con trastorno por déficit de atención-hiperactividad de tipo combinado (TDAH-C), con niños controles, en la tarea de interferencia multi-fuente (TIMF), evaluado por la negatividad relacionada al error (NRE). Método: Estudiamos 12 niños con TDAH-C con una mediana de 7 años, los controles estuvieron pareados por edad y género. Los niños realizaron la TIMF con registros simultáneos de NRE. Resultados: No encontramos diferencias en los parámetros de la TIMF entre grupos. No encontramos diferencias en las variables de la NRE entre grupos. Encontramos asociaciones significativas entre la amplitud de la NRE en niños con TDAH-C. Una correlación fue en dirección positiva: (frecuencia de aciertos y amplitud de TIMF), y otras fueron en dirección negativa (frecuencia de errores y el tiempo de respuesta en la TIMF). Conclusión: Los niños con TDAH-C presentan una asociación significativa entre la amplitud de la NRE con la TIMF. Los resultados sugieren la participación de la red cíngulo-fronto-parietal y pueden ayudar en la comprensión de los mecanismos fisiopatológicos del TDAH-C.Palabras clave: trastorno por déficit de atención-hiperactividad, tarea de interferencia multi-fuente, potenciales relacionados a eventos cognoscitivos, negatividad relacionada al error, red cíngulo-fronto-parietal.Attention deficit-hyperactivity disorder (ADHD) is an alteration whose main symptoms are inattention, hyperactivity, and impulsivity 1 . Children with ADHD present difficulties in several areas, such as those related to school, home or different social environments that affect their Quality of Life (QoL) 2 . Children with ADHD present alterations in other domains, such as executive functions (EF) 3 . Children with ADHD can be classified in three groups as follows: predominantly

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Functional Magnetic Resonance Imaging of Methylphenidate and Placebo in Attention-Deficit/Hyperactivity Disorder During the Multi-Source Interference Task

Abstract: Methylphenidate OROS increased daMCC activation during the MSIT and may act, in part, by normalizing daMCC hypofunction in ADHD.

Cited by 177 publications

References 117 publications

Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial

Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial

Attention-Deficit/Hyperactivity Disorder and Attention Networks

Error related negativity and multi-source interference task in children with attention deficit hyperactivity disorder-combined type

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