2019
DOI: 10.1016/j.mri.2019.07.017
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Functional MRI and resting state connectivity in white matter - a mini-review

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Cited by 126 publications
(118 citation statements)
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References 33 publications
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“…First, Pearson's correlation coefficient is the most commonly used metric to measure the FC among GM regions, but its accuracy has been proven to be limited [68]. Given the lower SNR in WM BOLD signals compared to GM signals and the difference in hemodynamic response function between WM and GM [20,69], the Pearson's correlation coefficient appears to be even less accurate to represent WM-GM FC. In future, it will be interesting to find better metrics for detecting earlier stages of AD.…”
Section: Discussionmentioning
confidence: 99%
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“…First, Pearson's correlation coefficient is the most commonly used metric to measure the FC among GM regions, but its accuracy has been proven to be limited [68]. Given the lower SNR in WM BOLD signals compared to GM signals and the difference in hemodynamic response function between WM and GM [20,69], the Pearson's correlation coefficient appears to be even less accurate to represent WM-GM FC. In future, it will be interesting to find better metrics for detecting earlier stages of AD.…”
Section: Discussionmentioning
confidence: 99%
“…In this study, we extended these new findings and analyses, originally described in our previous work [19][20][21][22], to quantify changes in WM fMRI metrics during the progression to ADD. We measured the differences in the FCMs for WM-GM correlations (FCM WG ) and WM-WM correlations (FCM WW ) between a healthy group and each of five participant groups at different stages of cognitive impairments.…”
Section: Introductionmentioning
confidence: 88%
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“…Whether BOLD signals in WM are related to intrinsic neural activity, or are the result of vascular changes in neighboring cortex, or some other processes, remains unclear, but efforts have been made by several groups to detect and evaluate BOLD signals in WM. In fact, a growing number of studies have shown the feasibility of reliably detecting functional activation and connectivity by fMRI in WM ( Ding et al, 2013 , 2018 , 2016 ; Gore et al, 2019 ; Grajauskas et al, 2019 ). For instance, Mazerolle et al reported functional activation in the isthmus of the corpus callosum by using a Sperry task and high field imaging (4 T) ( Mazerolle et al, 2008 ).…”
Section: Introductionmentioning
confidence: 99%
“…2007 ; Caballero-Gaudes and Reynolds 2017 ). In recent years, an increasing body of evidence indicates that BOLD signals within WM appear to reflect neural activities ( Gore et al. 2019 ).…”
Section: Introductionmentioning
confidence: 99%