Functional MRI markers for treatment-resistant depression: Insights and challenges

Kotoula, Vasileia; Evans, Jovier D.; Punturieri, Claire; Johnson, Sara Campbell; Zarate, Carlos A.

doi:10.1016/bs.pbr.2023.04.001

Cited by 8 publications

(4 citation statements)

References 73 publications

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“…Furthermore, Evans et al (2018) demonstrated normalization of the functional connectivity between the insular cortex [part of the salience network (SN)], and the default mode 10.3389/fnins.2023.1267647 network (DMN) 2 days following a single ketamine infusion; however, this effect was no longer present in a subsequent measurement 8 days later. Kotoula et al (2023) presented a very detailed and insightful review on the brain changes accompanying TRD and on TRD treatment with rTMS, ketamine, and other methods.…”

Section: Ketamine-induced Neuroplasticitymentioning

confidence: 99%

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Dębowska,

Więdłocha,

Dębowska

et al. 2023

Front. Neurosci.

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Drug-resistant mental disorders, particularly treatment-resistant depression, pose a significant medical and social problem. To address this challenge, modern psychiatry is constantly exploring the use of novel treatment methods, including biological treatments, such as transcranial magnetic stimulation (TMS), and novel rapid-acting antidepressants, such as ketamine. While both TMS and ketamine demonstrate high effectiveness in reducing the severity of depressive symptoms, some patients still do not achieve the desired improvement. Recent literature suggests that combining these two methods may yield even stronger and longer-lasting results. This review aims to consolidate knowledge in this area and elucidate the potential mechanisms of action underlying the increased efficacy of combined treatment, which would provide a foundation for the development and optimization of future treatment protocols.

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Section: Ketamine-induced Neuroplasticitymentioning

confidence: 99%

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Dębowska,

Więdłocha,

Dębowska

et al. 2023

Front. Neurosci.

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“…In addition, multiparametric methods have been used to evaluate demyelinating (like multiple sclerosis) diseases in clinical settings. Similarly, if molecular imaging techniques are combined with other advanced imaging technologies such as functional MRI, high-precision structural MRI, and deep learning, it may provide a more comprehensive characterization of the pathology of psychiatric disorders (Lai et al ., 2019 ; Mustafi et al ., 2019 ; Gatto et al ., 2021 ; Kotoula et al ., 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Progress in the application of molecular imaging in psychiatric disorders

Tan,

Zhang,

Hao

et al. 2023

Psychoradiology

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Psychiatric disorders have always attracted a lot of attention from researchers due to the difficulties in their diagnoses and treatments. Molecular imaging, as an emerging technology, has played an important role in the researchers of various diseases. In recent years, molecular imaging techniques including magnetic resonance spectroscopy, nuclear medicine imaging, and fluorescence imaging have been widely used in the study of psychiatric disorders. This review will briefly summarize the progression of molecular imaging in psychiatric disorders.

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“…The DMN, typically active when the mind is in a restful state and not engaged with the external environment, is often linked to self-referential thinking ( 27 ). Interestingly, while TRD patients exhibited increased functional connectivity within the DMN ( 28 ), those with MDD displayed the opposite trend ( 29 ). Such DMN dysregulation in MDD may correlate with the ruminative thought patterns observed in these patients ( 30 ).…”

Section: Introductionmentioning

confidence: 99%

Alterations in brain network connectivity and subjective experience induced by psychedelics: a scoping review

Yu,

Burback,

Winkler

et al. 2024

Front. Psychiatry

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Intense interest surrounds current research on psychedelics, particularly regarding their potential in treating mental health disorders. Various studies suggest a link between the subjective effects produced by psychedelics and their therapeutic efficacy. Neuroimaging evidence indicates an association of changes in brain functional connectivity with the subjective effects of psychedelics. We conducted a review focusing on psychedelics and brain functional connectivity. The review focused on four psychedelic drugs: ayahuasca, psilocybin and LSD, and the entactogen MDMA. We conducted searches in databases of MEDLINE, Embase, APA PsycInfo and Scopus from inception to Jun 2023 by keywords related to functional connectivity and psychedelics. Using the PRISMA framework, we selected 24 articles from an initial pool of 492 for analysis. This scoping review and analysis investigated the effects of psychedelics on subjective experiences and brain functional connectivity in healthy individuals. The studies quantified subjective effects through psychometric scales, revealing significant experiences of altered consciousness, mood elevation, and mystical experiences induced by psychedelics. Neuroimaging results indicated alterations in the functional connectivity of psychedelics, with consistent findings across substances of decreased connectivity within the default mode network and increased sensory and thalamocortical connectivity. Correlations between these neurophysiological changes and subjective experiences were noted, suggesting a brain network basis of the psychedelics’ neuropsychological impact. While the result of the review provides a potential neural mechanism of the subjective effects of psychedelics, direct clinical evidence is needed to advance their clinical outcomes. Our research serves as a foundation for further exploration of the therapeutic potential of psychedelics.

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Functional MRI markers for treatment-resistant depression: Insights and challenges

Cited by 8 publications

References 73 publications

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression

Progress in the application of molecular imaging in psychiatric disorders

Alterations in brain network connectivity and subjective experience induced by psychedelics: a scoping review

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