“…In addition, nAChRs can modulate GABAergic transmission in multiple brain areas, such as thalamus, cortex, hippocampus, and interpeduncular nucleus (Lena et al, 1993;Alkondon et al, 1997Alkondon et al, , 2000Lena and Changeux, 1997;Fisher et al, 1998;Radcliffe et al, 1999). Modulation of GABA neurons by nAChRs has been most extensively studied in the hippocampus, where GABAergic interneurons express multiple nAChR subtypes (Alkondon et al, 1997;Jones and Yakel, 1997;Frazier et al, 1998b;McQuiston and Madison, 1999;Ji and Dani, 2000). The physiologic impact of nAChR activation is critically dependent upon their localization.…”