Functional Outcome in Patients With Schizophrenia: The Concept and Measurement

Sumiyoshi, Chika; Sumiyoshi, Tomiki

doi:10.1007/bf03379619

Cited by 10 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the degree of activities of ‘Visiting friends’ is well defined as ‘Never’=0 times [0 point]; Rarely = more than once in recent 3 months [1]; Sometimes = more than once in a month [2]; Often=more than once in a week [3]. A positive correlation between scores of this Japanese version of the SFS and MCCB has been reported in our preliminary study ( Sumiyoshi and Sumiyoshi, 2015 ).…”

Section: Methodsmentioning

confidence: 89%

See 1 more Smart Citation

Factors predicting work outcome in Japanese patients with schizophrenia: role of multiple functioning levels

Sumiyoshi

Harvey

Takaki

et al. 2015

Schizophrenia Research: Cognition

Self Cite

View full text Add to dashboard Cite

Functional outcomes in individuals with schizophrenia suggest recovery of cognitive, everyday, and social functioning. Specifically improvement of work status is considered to be most important for their independent living and self-efficacy. The main purposes of the present study were 1) to identify which outcome factors predict occupational functioning, quantified as work hours, and 2) to provide cut-offs on the scales for those factors to attain better work status. Forty-five Japanese patients with schizophrenia and 111 healthy controls entered the study. Cognition, capacity for everyday activities, and social functioning were assessed by the Japanese versions of the MATRICS Cognitive Consensus Battery (MCCB), the UCSD Performance-based Skills Assessment-Brief (UPSA-B), and the Social Functioning Scale Individuals’ version modified for the MATRICS-PASS (Modified SFS for PASS), respectively. Potential factors for work outcome were estimated by multiple linear regression analyses (predicting work hours directly) and a multiple logistic regression analyses (predicting dichotomized work status based on work hours). ROC curve analyses were performed to determine cut-off points for differentiating between the better- and poor work status. The results showed that a cognitive component, comprising visual/verbal learning and emotional management, and a social functioning component, comprising independent living and vocational functioning, were potential factors for predicting work hours/status. Cut-off points obtained in ROC analyses indicated that 60–70% achievements on the measures of those factors were expected to maintain the better work status. Our findings suggest that improvement on specific aspects of cognitive and social functioning are important for work outcome in patients with schizophrenia.

show abstract

Section: Methodsmentioning

confidence: 89%

“…First, it has been shown that patients and informants ratings on the SFS were highly correlated ( Dickerson et al, 1997 ). Second, the SFS ratings have been reported to be correlated with those of the SLOF, which is an informant-based objective measure ( Sumiyoshi et al, unpublished data ).…”

Section: Discussionmentioning

confidence: 99%

Factors predicting work outcome in Japanese patients with schizophrenia: role of multiple functioning levels

Sumiyoshi

Harvey

Takaki

et al. 2015

Schizophrenia Research: Cognition

Self Cite

View full text Add to dashboard Cite

show abstract

“… 2 – 6 Functional outcome is defined as a wide range of real-world functions including independent living, financial management, employment, and leisure/social activities. 7 , 8 So, social function investigated in this study is considered to be a part of functional outcome. 9 Finding contributors to functional outcome is an important issue in schizophrenia research and clinical intervention.…”

Section: Introductionmentioning

confidence: 99%

Relationship between social and cognitive functions in people with schizophrenia

Tominaga

Tomotake

Takeda

et al. 2018

NDT

View full text Add to dashboard Cite

PurposeThe purpose of the present study was to examine clinical factors related to social function in people with schizophrenia.Patients and methodsThe participants were 55 stabilized outpatients with schizophrenia. Their mean age was 39.36 (SD =10.65) years. Social function was assessed using the Quality of Life Scale (QLS). Cognitive function was evaluated with the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). Clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), the Calgary Depression Scale for Schizophrenia, and the Drug-Induced Extrapyramidal Symptoms Scale.ResultsNeither the MCCB cognitive domain score nor composite score was correlated with the QLS scores. However, of the 10 MCCB subtests, the Trail Making Test Part A and the Brief Assessment of Cognition in Schizophrenia-Symbol Coding (BACS-SC) scores were positively correlated with the QLS scores. Among clinical variables, especially the PANSS negative syndrome scale score had a strong negative correlation with the QLS scores. Stepwise regression analyses showed that the PANSS negative syndrome scale score was an independent predictor of the QLS scores, and although the BACS-SC score predicted the QLS common objects and activities subscale score, the association was not so strong compared to the PANSS negative syndrome scale score.ConclusionThese results indicate that speed of processing evaluated by BACS-SC could predict some aspect of social function but negative symptoms have a much stronger impact on global social function in people with schizophrenia.

show abstract

“…In this context, intermediate functional measures, or “co-primary measures,” have attracted interest as a target for therapeutic intervention (Sumiyoshi and Sumiyoshi, in press). For example, a greater sensitivity to treatment has been reported for co-primary measures compared to primary measures in a clinical trial of lurasidone and ziprasidone (Harvey et al, 2011).…”

Section: Perspectivesmentioning

confidence: 99%

Neural Basis for the Ability of Atypical Antipsychotic Drugs to Improve Cognition in Schizophrenia

Sumiyoshi¹,

Higuchi²,

Uehara³

2013

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

Cognitive impairments are considered to largely affect functional outcome in patients with schizophrenia, other psychotic illnesses, or mood disorders. Specifically, there is much attention to the role of psychotropic compounds acting on serotonin (5-HT) receptors in ameliorating cognitive deficits of schizophrenia. It is noteworthy that atypical antipsychotic drugs (AAPDs), e.g., clozapine, melperone, risperidone, olanzapine, quetiapine, aripiprazole, perospirone, blonanserin, and lurasidone, have variable affinities for these receptors. Among the 5-HT receptor subtypes, the 5-HT1A receptor is attracting particular interests as a potential target for enhancing cognition, based on preclinical and clinical evidence. The neural network underlying the ability of 5-HT1A agonists to treat cognitive impairments of schizophrenia likely includes dopamine, glutamate, and gamma-aminobutyric acid neurons. A novel strategy for cognitive enhancement in psychosis may be benefited by focusing on energy metabolism in the brain. In this context, lactate plays a major role, and has been shown to protect neurons against oxidative and other stressors. In particular, our data indicate chronic treatment with tandospirone, a partial 5-HT1A agonist, recover stress-induced lactate production in the prefrontal cortex of a rat model of schizophrenia. Recent advances of electrophysiological measures, e.g., event-related potentials, and their imaging have provided insights into facilitative effects on cognition of some AAPDs acting directly or indirectly on 5-HT1A receptors. These findings are expected to promote the development of novel therapeutics for the improvement of functional outcome in people with schizophrenia.

show abstract

Functional Outcome in Patients With Schizophrenia: The Concept and Measurement

Cited by 10 publications

References 25 publications

Factors predicting work outcome in Japanese patients with schizophrenia: role of multiple functioning levels

Factors predicting work outcome in Japanese patients with schizophrenia: role of multiple functioning levels

Relationship between social and cognitive functions in people with schizophrenia

Neural Basis for the Ability of Atypical Antipsychotic Drugs to Improve Cognition in Schizophrenia

Contact Info

Product

Resources

About