Functional Outcomes and Quality of Life after Cochlear Implantation in Patients with Long-Term Deafness

Óvári, Attila; Hühnlein, Lisa; Nguyen-Dalinger, David; Strüder, Daniel; Külkens, Christoph; Niclaus, O; Meyer, Jens E.

doi:10.3390/jcm11175156

Cited by 12 publications

(8 citation statements)

References 46 publications

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“…These findings are consistent with studies reporting the overall benefits of CIs at later ages, particularly in terms of QOL . Thus, while speech intelligibility may be poorer for children receiving implants later as reported in the literature, these children may still benefit in terms of QOL . Cochlear implant centers should routinely incorporate assessment of QOL into their practice, using newly developed adult and pediatric condition-specific measures (ie, CI-QoL, QoL-CI) .…”

Section: Discussionsupporting

confidence: 86%

Cochlear Implantation and Educational and Quality-of-Life Outcomes in Adolescence

Barker

Petruzzello

Sarangoulis

et al. 2023

JAMA Otolaryngol Head Neck Surg

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ImportanceCochlear implants (CIs) have been shown to be effective in improving auditory skills and speech and language development. However, less is known about the long-term outcomes of CIs on educational functioning or quality of life.ObjectiveTo evaluate long-term educational outcomes and quality of life in adolescents over 13 years postimplantation.Design, Setting, and ParticipantsThis longitudinal cohort study included 188 children with bilateral severe to profound hearing loss with CIs from the Childhood Development After Cochlear Implantation (CDaCI) study from hospital-based CI programs; a cohort of 340 children with severe to profound hearing loss without CIs from a nationally representative survey (National Longitudinal Transition Study-2; NLTS-2), and results from the literature of comparable children without CIs.Exposure(s)Cochlear implantation (early and late).Main Outcomes and MeasuresAdolescent performance on measures of academic achievement (Woodcock Johnson), language (Comprehensive Assessment of Spoken Language), and quality of life (Pediatric Quality of Life Inventory, Youth Quality of Life Instrument–Deaf and Hard of Hearing ).ResultsThe CDaCI cohort included 188 children, 136 of whom completed the wave 3 postimplantation follow-up visits (77 [55%] female) with CIs; mean [SD] age was 11.47 [1.27] years. The NLTS-2 cohort included 340 children (50% female) with severe to profound hearing loss without CIs. Children with CIs had better academic performance compared with children without CIs with similar levels of hearing loss. The largest benefits were seen for children who received implants early (prior to age 18 months), who performed at or above age and gender norms for language and academic achievement. Similarly, adolescents with CIs reported better quality of life on the Pediatric Quality of Life Inventory compared with children without CIs. On a condition-specific measure (Youth Quality of Life Instrument–Deaf and Hard of Hearing), children who received implants early scored higher across all 3 domains than comparisons without CIs.Conclusions and RelevanceTo our knowledge, this is the first study to evaluate long-term educational outcomes and quality of life in adolescents using CIs. This longitudinal cohort study showed better outcomes of CIs in terms of language, academic performance, and quality of life. While the greatest benefits were observed for children who received implants before age 18 months, benefits were also noted for children who received implants later, providing evidence that children with severe to profound hearing loss with CIs can achieve at or above expected levels compared with hearing peers.

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Section: Discussionsupporting

confidence: 86%

Cochlear Implantation and Educational and Quality-of-Life Outcomes in Adolescence

Barker

Petruzzello

Sarangoulis

et al. 2023

JAMA Otolaryngol Head Neck Surg

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“…We additionally analyzed patient‐reported benefits given the growing volume of research on limitations of in‐office open‐set testing to reflect everyday listening conditions. Moreover, improvement in speech recognition scores does not correlate well with improvement in QOL reporting 30‐32 . We included the SSQ as well as the CIQOL‐10, which is CI‐specific 30‐32 .…”

Section: Discussionmentioning

confidence: 99%

“…[30][31][32] We included the SSQ as well as the CIQOL-10, which is CI-specific. [30][31][32] The SSQ scale was initially applied to and developed for hearing aid users but has shown improvement in scores after cochlear implantation. 33,34 The CIQOL was introduced by McCracken et al and was created specifically and rigorously for CI users.…”

Section: 2022mentioning

confidence: 99%

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Cochlear Implant Qualification in Noise Versus Quiet: Do Patients Demonstrate Similar Postoperative Benefits?

Schauwecker,

Patro,

Holder

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveTo assess patient factors, audiometric performance, and patient‐reported outcomes in cochlear implant (CI) patients who would not have qualified with in‐quiet testing alone.Study DesignRetrospective chart review.SettingTertiary referral center.MethodsAdult CI recipients implanted between 2012 and 2022 were identified. Patients with preoperative AzBio Quiet > 60% in the implanted ear, requiring multitalker babble to qualify, comprised the in‐noise qualifying (NQ) group. NQ postoperative performance was compared with the in‐quiet qualifying (QQ) group using CNC, AzBio Quiet, and AzBio +5 dB signal‐to‐noise ratio. Speech, Spatial and Qualities of Hearing Scale (SSQ), Cochlear Implant Quality of Life scale (CIQOL‐10), and daily device usage were also compared between the groups.ResultsThe QQ group (n = 771) and NQ group (n = 67) were similar in age and hearing loss duration. NQ had higher average preoperative and postoperative speech recognition scores. A larger proportion of QQ saw significant improvement in CNC and AzBio Quiet scores in the CI‐only listening condition (eg, CI‐only AzBio Quiet: 88% QQ vs 51% NQ, P < .001). Improvement in CI‐only AzBio +5 dB and in all open set testing in the best‐aided binaural listening condition was similar between groups (eg, Binaural AzBio Quiet 73% QQ vs 59% NQ, P = .345). Postoperative SSQ ratings, CIQOL scores, and device usage were also equivalent between both groups.ConclusionPatients who require in‐noise testing to meet CI candidacy demonstrate similar improvements in best‐aided speech perception and patient‐reported outcomes as in‐QQ, supporting the use of in‐noise testing to determine CI qualification for borderline CI candidates.

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“…According to statistics from the World Health Organization, there are currently approximately 466 million people suffering from hearing impairment, with the incidence rate increasing year after year. Although deafness may not immediately endanger the patient's life, it can signi cantly impair the patient's quality of life and work achievement (Gaylor et al 2013;Ovari et al 2022). Hearing loss is the most prevalent sensory disability, and sensory hearing loss (SNHL) is the most frequent congenital sensory condition in children (Kenna 2015).…”

Section: Introductionmentioning

confidence: 99%

Gipc3 Mutation Might Cause Sensorineural Hearing Loss by Inhibiting Mitophagy in Inner Ear Hair Cells

Li,

Wang,

Shi

et al. 2024

Preprint

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Sensory hearing loss (SNHL) has a high degree of genetic heterogeneity, and there are many mutated genes that cause deafness. GIPC3 gene is one of the mutated genes that can cause congenital hearing loss found in recent years, but the mechanism of its cause is still unclear. Mitophagy is the process of selectively encapsulating and lysing damaged or dysfunctional mitochondria in order to prevent accumulation of damaged mitochondria from damaging the cells and is of great importance in the maintenance of homeostasis in the inner ear. The aim of this paper is to observe the effect of Gipc3 expression on mitochondrial metabolism and autophagy in inner ear hair cells, and to explore the possible mechanism of sensorineural hearing loss caused by Gipc3 mutations. In this study, The House Ear Institute Organ of Corti 1(HEI-OC1) cells and cochlear explants were cultured to change the expression level of Gipc3 by transfection, and the knockdown efficiency was examined by quantitative polymerase chain reaction (qPCR) and Western Blot. Knockdown of Gipc3 inhibited cell viability and its proliferation ability. When t-BHP was used to induce oxidative stress injury and knockdown of Gipc3, inner ear hair cells had weakened ability to resist oxidative stress injury, mitochondrial metabolism was altered, and there was accumulation of reactive oxygen species and reduction of mitochondrial membrane potential. Immunofluorescence and Western Blot techniques revealed that the mitochondrial autophagy-related proteins, LC3B and P62, showed autophagy disorders. A PH domain, leucine zipper motif 1(APPL1) mediates early endosome-dependent mitophagy, and deletion of APPL1 impairs mitochondrial autophagy. We found that fluorescence co-localization exists between Gipc3 and APPL1, and that they interact with each other, with positive correlation in their trends. In summary, Gipc3 mutation may lead to decreased mitochondrial function by inhibiting the APPL1-mediated mitochondrial autophagy process, out of which impaired oxidative metabolism in hair cells may occur, which is a possible mechanism for the inhibition of mitochondrial autophagy by Gipc3 mutation.

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Functional Outcomes and Quality of Life after Cochlear Implantation in Patients with Long-Term Deafness

Cited by 12 publications

References 46 publications

Cochlear Implantation and Educational and Quality-of-Life Outcomes in Adolescence

Cochlear Implantation and Educational and Quality-of-Life Outcomes in Adolescence

Cochlear Implant Qualification in Noise Versus Quiet: Do Patients Demonstrate Similar Postoperative Benefits?

Gipc3 Mutation Might Cause Sensorineural Hearing Loss by Inhibiting Mitophagy in Inner Ear Hair Cells

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