Functional polymorphisms in the interleukin-12 gene contribute to cancer risk: Evidence from a meta-analysis of 18 case–control studies

Zhou, Liping; Yao, Fan; Luan, Hong; Wang, Yinling; Dong, Xi-Hua; Zhou, Wenwen; Wang, Qihui

doi:10.1016/j.gene.2012.08.019

Cited by 24 publications

(25 citation statements)

References 44 publications

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“…Moreover, two meta-analyses of IL-12 gene functional polymorphisms by Chen H and Zhou L support our findings Zhou et al, 2012). However, Jaiswal PK reported an inconstant result, discovering that A /C heterozygote genotype and C allele carrier demonstrated reduced risk of BC (Jaiswal et al, 2013); this inconstant report could be due to different ethnicity or sample size.…”

Section: Discussionsupporting

confidence: 77%

“…The 1188 A/C polymorphism has been shown to influenceIL-12 production or protein expression and was associated with Th1-mediated diseases (Lin and Chien, 2004). Moreover, results from the current meta-analysis indicate that 1188 A/C polymorphism was associated with a significantly increased overall risk of cancer (Zhou et al, 2012).…”

Section: Mojgan Asgarymentioning

confidence: 72%

“…Variation in the DNA sequence may lead to altered IL-12 production, and this can alter an individual's susceptibility to cancer. The IL12B 3'UTR A>C polymorphism is a functionally important SNP that alters Il-12 production and it has been a reported potential biomarker for risks of some cancers,such as cervical, colorectal, gastric, breast and several others (Zhou et al, 2012); thus, we aimed to investigate the association between this polymorphism and bladder cancer among the Iranian population.…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile clinical research has shown that there is a correlation between the IL-12 SNPs and levels of serum IL-12 with disease severity in cancer patients (Murakami et al, 2004). Based on HGMD, 14 pathogenic mutations have been found to date (www.portal.biobaseinternational.com), and many studies have focused mainly on 3'UTR, 1188A>C (rs3212227) in the IL-12B gene (Zhou et al, 2012). The 1188 A/C polymorphism has been shown to influenceIL-12 production or protein expression and was associated with Th1-mediated diseases (Lin and Chien, 2004).…”

Section: Mojgan Asgarymentioning

confidence: 99%

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Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Ebadi

Jahed²,

Mivehchi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Interleukin-12 (IL-12) as an antitumor and interleukin-6 (IL-6) as an inflammatory cytokine, are immunomodulatory products that play important roles in responses in cancers and inflammation. We tested the association between two polymorphisms of IL-12(1188A>C; rs3212227) and IL-6 (-174 C>G) and the risk of bladder cancer in 261 patients and 251 healthy individuals. We also investigated the possible association of these SNPs in patients with high-risk jobs and smoking habits with the incidence of bladder cancer. The genotype distributions of IL-6 (-174 C/G) genotype were similar between the cases and the control groups; however, among patients with smoking habits, the association between IL-6 gene polymorphism and incidence of bladder cancer was significant. After a control adjustment for age and sex, the following results were recorded: CC genotype (OR= 2.11, 95%CI=1.56-2.87, p=0.

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Section: Discussionsupporting

confidence: 77%

Section: Mojgan Asgarymentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Mojgan Asgarymentioning

confidence: 99%

See 2 more Smart Citations

Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Ebadi

Jahed²,

Mivehchi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Patients with chronic HBV infection were enrolled in this study (n = 1191, female, 424; male, 767; median age, 36; range, [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42], and the control population demonstrated previous HBV clearance (n = 273; female, 111; male, 162; median age, 42; range, 33-49). A significant difference was found between HBV clearance and chronic HBV infection for age (P < 0.0001).…”

Section: Patientsmentioning

confidence: 99%

Interaction of TLR–IFN and HLA polymorphisms on susceptibility of chronic HBV infection in Southwest Han Chinese

Shen

Guo

et al. 2015

Liver International

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Background & Aims: The toll-like receptor-interferon (TLR-IFN) signalling pathway plays a crucial role in HBV infection. Human leucocyte antigen (HLA) polymorphisms are associated with chronic HBV infection by genome wide association study (GWAS). We aimed to explore interaction between TLR-IFN and HLA gene polymorphisms in susceptibility of chronic HBV infection. Methods: In the Chinese Southwest Han population, 1191 chronic HBV infection patients and 273 HBV clearance were selected. A total of 39 single nucleotide polymorphism loci in 23 genes of the TLR-IFN pathway and four HLA polymorphism loci associated with chronic HBV infection identified by GWAS were selected for genotyping. SNPStats, QVALUE, and multifactor dimensionality reduction were used for statistical analysis. Results: A significant association was seen in several of the TLR-IFN pathway genes, TLR9 rs352140 (OR = 0.70, P = 0.0088), IL1B rs16944 (OR = 0.67, P = 0.016), IL12B rs3212227 (OR = 1.38, P = 0.021), IFNGR1 rs3799488 (OR = 1.48, P = 0.0048), IFNGR2 rs1059293 (OR = 0.27, P = 0.011), MX1 rs467960 (OR = 0.68, P = 0.022), as well as four loci in HLA, rs3077 (OR = 0.55, P < 0.0001), rs2856718 (OR = 0.60, P = 4e-04), rs9277535 (OR = 0.54, P < 0.0001) and rs7453920 (OR = 0.43, P < 0.0001). A synergistic relationship was seen between rs9277535 and rs16944 (0.13%), rs1143623 and rs6613 (0.10%). The combination of rs9277535 in HLA and rs16944 in IL1B was the best model to predict chronic HBV infection (testing accuracy = 0.6040, P = 0.0010, cross-validation consistency = 10/10). Conclusions: TLR-IFN pathway gene polymorphisms are associated with chronic HBV infection. Interactions with polymorphisms in these genes may be one mechanism by which HLA polymorphisms influence susceptibility to chronic HBV infection, as specific single nucleotide polymorphism combinations are highly predictive of chronic HBV infection.

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Immunogenetics of Cancer

Hirbod-Mobarakeh¹,

Shabani²,

Keshavarz-Fathi³

et al. 2020

Cancer Immunology

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Functional polymorphisms in the interleukin-12 gene contribute to cancer risk: Evidence from a meta-analysis of 18 case–control studies

Cited by 24 publications

References 44 publications

Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Interaction of TLR–IFN and HLA polymorphisms on susceptibility of chronic HBV infection in Southwest Han Chinese

Immunogenetics of Cancer

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