Functional PstI/RsaI Polymorphisms in the CYP2E1 Gene among South Indian Populations

Lakkakula, Saikrishna; Maram, Rajasekhar; Munirajan, Arasambattu Kannan; Pathapati, Ram Mohan; Visweswara, Subrahmanyam Bhattaram; Lakkakula, Bhaskar Vks

doi:10.7314/apjcp.2013.14.1.179

Cited by 11 publications

(9 citation statements)

References 26 publications

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“…The genotype distribution and allele frequencies of CYP2E1 polymorphism differ significantly across different populations (Bolt et al, 2003;Shahriary et al, 2012;Lakkakula et al, 2013). In Malaysia, there is a high prevalence of nasopharyngeal cancer in the major indigenous groups and high cases of tuberculosis in Sabah (Rundi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Significant Genotype Difference in the CYP2E1 PstI Polymorphism of Indigenous Groups in Sabah, Malaysia with Asian and Non-Asian Populations

Goh¹,

Chong²,

Chua³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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CYP2E1 PstI polymorphism G-1259C (rs3813867) genotype distributions vary significantly among different populations and are associated with both diseases, like cancer, and adverse drug effects. To date, there have been limited genotype distributions and allele frequencies of this polymorphism reported in the three major indigenous ethnic groups (KadazanDusun, Bajau, and Rungus) in Sabah, also known as North Borneo. The aim of this study was to investigate the genotype distributions and allele frequencies of the CYP2E1 PstI polymorphism G-1259C in these three major indigenous peoples in Sabah. A total of 640 healthy individuals from the three dominant indigenous groups were recruited for this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) at G-1259C polymorphic site of CYP2E1 gene was performed using the Pst I restriction enzyme. Fragments were analyzed using agarose gel electrophoresis and confirmed by direct sequencing. Overall, the allele frequencies were 90.3% for c1 allele and 9.7% for c2 allele. The genotype frequencies for c1/c1, c1/c2 and c2/c2 were observed as 80.9%, 18.8%, and 0.3%, respectively. A highly statistical significant difference (p<0.001) was observed in the genotype distributions between indigenous groups in Sabah with all Asian and non-Asian populations. However, among these three indigenous groups, there was no statistical significant difference (p>0.001) in their genotype distributions. The three major indigenous ethnic groups in Sabah show unique genotype distributions when compared with other populations. This finding indicates the importance of establishing the genotype distributions of CYP2E1 PstI polymorphism in the indigenous populations.

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Section: Introductionmentioning

confidence: 99%

Significant Genotype Difference in the CYP2E1 PstI Polymorphism of Indigenous Groups in Sabah, Malaysia with Asian and Non-Asian Populations

Goh¹,

Chong²,

Chua³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Although many studies around the world have been carried out so far to examine the association of CYP2E1 polymorphism and various cancer risk including stomach cancer, the results are not consistent and ethnic differences has been reported (Wang et al, 2010;Ye et al, 2010;Balaji et al, 2011;Shahriary et al, 2012;Tian et al, 2012;Lakkakula et al, 2013). Few studies revealed a positive association between CYP2E1 RsaI polymorphism and stomach cancer risk Boccia et al, 2007).…”

Section: Discussionmentioning

confidence: 96%

CYP2E1 Genetic Polymorphism with Dietary, Tobacco, Alcohol Habits, H. pylori Infection Status and Susceptibility to Stomach Cancer in Mizoram, India

Malakar

Devi²,

Phukan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…It was indicated that the genetic diversity and variants among different ethnicities or populations might contribute to cancer risk (Shahriary et al, 2012;Lakkakula et al, 2013). Although the underlying mechanisms were not clear, ethnic diversity might affect bladder cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Functional RsaI/PstI Polymorphism in Cytochrome P450 2E1 Contributes to Bladder Cancer Susceptibility: Evidence from a Meta-analysis

Deng

Gao²,

Zhang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Cytochrome P450 2E1 (CYP2E1) might be involved in the development of bladder cancer. However, previous studies of any association between CYP2E1 RsaI/PstI polymorphism and bladder cancer risk have yielded conflicting results. In this study, we performed a more precise estimation of the relationship by a meta-analysis based on the currently available evidence from the literature. Method: To assess the effect of CYP2E1 RsaI/PstI polymorphism on bladder cancer susceptibility, a meta-analysis of 6 available studies with 1,510 cases and 1,560 controls were performed through Feb 2014. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to estimate the strength of association for CYP2E1 RsaI/PstI polymorphism under different genetic models. Results: When available studies were pooled into the meta-analysis, we found that the C1C2 and C2C2 genotypes of CYP2E1 RsaI/PstI polymorphism significantly decreased bladder cancer risk

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Functional PstI/RsaI Polymorphisms in the CYP2E1 Gene among South Indian Populations

Cited by 11 publications

References 26 publications

Significant Genotype Difference in the CYP2E1 PstI Polymorphism of Indigenous Groups in Sabah, Malaysia with Asian and Non-Asian Populations

Significant Genotype Difference in the CYP2E1 PstI Polymorphism of Indigenous Groups in Sabah, Malaysia with Asian and Non-Asian Populations

CYP2E1 Genetic Polymorphism with Dietary, Tobacco, Alcohol Habits, H. pylori Infection Status and Susceptibility to Stomach Cancer in Mizoram, India

Functional RsaI/PstI Polymorphism in Cytochrome P450 2E1 Contributes to Bladder Cancer Susceptibility: Evidence from a Meta-analysis

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