2022
DOI: 10.1016/j.jstrokecerebrovasdis.2022.106508
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Functional Recovery in Patients with Acute Stroke and Pre-Existing Disability: A Natural History Study

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Cited by 3 publications
(3 citation statements)
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“…We suspect most deaths were related to complications of acute stroke (e.g., disability-related events such as aspiration pneumonia) and may not have been influenced by antithrombotic treatment allocation. Furthermore, patients with stroke at our center often have a considerable pre-stroke disability, with one in six patients with stroke having a pre-stroke modified Rankin Scale score of 3 or 4, according to data from an overlapping cohort ( 16 ). These patients are at a high risk of death within 90 days (40–70%), many of whom did not have ventricular dysfunction (which should further increase the risk of death) ( 17 ).…”
Section: Discussionmentioning
confidence: 99%
“…We suspect most deaths were related to complications of acute stroke (e.g., disability-related events such as aspiration pneumonia) and may not have been influenced by antithrombotic treatment allocation. Furthermore, patients with stroke at our center often have a considerable pre-stroke disability, with one in six patients with stroke having a pre-stroke modified Rankin Scale score of 3 or 4, according to data from an overlapping cohort ( 16 ). These patients are at a high risk of death within 90 days (40–70%), many of whom did not have ventricular dysfunction (which should further increase the risk of death) ( 17 ).…”
Section: Discussionmentioning
confidence: 99%
“…The scored model was also tested among patient subgroups stratified by premorbid mRS and admission ASPECTS. 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 Models were derived for the primary outcome, and were subsequently tested against secondary outcomes. Model discrimination was characterized by the area under the curve (AUC) with 95% CIs.…”
Section: Methodsmentioning
confidence: 99%
“… 1 This benefit has been confirmed for a highly specific, homogeneous population of patients without preexisting disability, with proximal occlusions, and minimal evidence of ischemic injury on baseline neuroimaging. 2 However, growing evidence from secondary analyses of randomized clinical trials and observational cohorts shows that patients with moderate preexisting disability, 3 , 4 , 5 distal occlusions, 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 and larger regions of early infarction 14 , 15 , 16 , 17 , 18 , 19 , 20 may also benefit from reperfusion treatment. By contrast, patients with milder presenting deficits 21 and those with completed infarctions on baseline neuroimaging in the late window 22 may not achieve better functional outcomes with EVT over BMM.…”
mentioning
confidence: 99%