Functional serotonin and histamine receptor subtypes in porcine ciliary artery in comparison with middle cerebral artery

Nagai, Shingo; Tsurumaki, Tatsuru; Abe, Haruki; Handa, Hiroshi

doi:10.1016/j.ejphar.2007.05.039

Cited by 5 publications

(3 citation statements)

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“…5-HT is a biogenic monoamine which mediates the smooth muscle contractility through the activation of different receptors (5-HT 1 to 5-HT 7 ). 13 Among them, 5-HT 1B , 5-HT 1D, 5-HT 2A , 5-HT 2B, 5-HT 4 , and 5-HT 7 receptors were shown to be expressed in blood vessels, even if messenger (mRNA) for 5-HT 2B and 5-HT 4 were only found in human endothelial cells. 14 The 5-HT 1B and 5-HT 1D receptors are coupled to G i /G o protein, which inhibits adenylate cyclase.…”

Section: Introductionmentioning

confidence: 99%

“…25 Histamine can induce contractility or relaxation depending on the expression and/or participation of different types of histamine receptors in each specific vascular vessel. 13,[26][27][28] In the current study, we studied the presence of different subtypes of 5-HT and histamine receptors and their functional role in the HUA tone regulation by using pharmacological, biochemical, and molecular approaches. Firstly, we examined the presence of mRNAs encoding different types of 5-HT and histamine receptors.…”

Section: Introductionmentioning

confidence: 99%

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Regulation of Human Umbilical Artery Contractility By Different Serotonin and Histamine Receptors

et al. 2009

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We studied the role of several serotonin (5-HT) and histamine receptors in the regulation of human umbilical artery (HUA) contractility. Among the 5-HT agonists used, only the 5-HT( 2A) and 5HT(1B/D) agonists contracts HUA. The 5-HT-induced contractions were fully inhibited by ketanserin (5-HT(2A) antagonist). The 5-HT( 7)-activation also relaxes and increases intracellular cyclic adenosine monophosphate (cAMP). Among the histamine receptor agonists, only betahistine (H(1) agonist) induced significant contractile effect. Histamine-induced contraction was partially relaxed by pyrilamine (H(1) antagonist). Betahistine-induced contraction was partially blocked by dimaprit (H( 2) agonist) and by the H(3) agonist when a low concentration of forskolin is present. Both, H(2) and H(3) agonists increased the cAMP intracellular levels in HUA smooth muscle. These findings show that in HUA, 5-HT(2A)- and 5-HT(1B/1D)-activation lead to vasoconstriction and 5-HT(7)-activation induces vasorelaxation. Concerning histamine receptors, H(1)-activation induces contraction and H(2)- and H(3)-activation lead to vasorelaxation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Regulation of Human Umbilical Artery Contractility By Different Serotonin and Histamine Receptors

et al. 2009

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“…In human eyes, histamine induced VD in the choroidal territory is NO dependent (VD is signifi cantly attenuated by concomitant administration of L-NMMA). In the porcine ciliary arteries, in vitro, blocking H 1 produces VD 20 . H 1 blockers have no eff ect on vascular size in rat iris 21 .…”

Section: The Histamine Systemmentioning

confidence: 97%

The Role of Histamine and Serotonin in the Control of Vascular Motricity of the Anterior Ocular Segment - Review of the Literature from 1997 to 2018

Lunca¹,

Păunescu²,

Coman³

et al. 2018

Rev. Med. Mod.

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Histamine and serotonin, besides known systemic effects, can influence vascular tone at the eye level. The review of the literature from 1997 to 2018 suggests that these ocular effects are very variable -both vasodilation and vasoconstriction. Specifi c agonists or antagonists acting in the histamine and serotonin domains, are probably more useful than endogenous substances as working tools for discovering the functional elements involved in regulating ocular vascular tone. Knowing that intraocular pressure regulation also depends on the vascular tone of the anterior ocular segment, some of the substances under review may be candidates for potential intraocular pressure lowering drugs. RezumatHistamina și serotonina, pe lângă efectele sistemice cunoscute, pot influenţa tonusul vascular de la nivel ocular. Recenzia literaturii de specialitate din perioada 1997-2018 a arătat că aceste efecte oculare sunt foarte variabileatât vasodilataţie, cât și vasoconstricţie. Substanţele care modulează la nivel de receptor aceste efecte (agoniștii și antagoniștii histaminergici și serotoninergici) sunt probabil mai utili decât substanţele endogene ca instrumente de lucru pentru descoperirea elementelor funcţionale implicate în reglarea tonusului vascular ocular. Cunoscând că reglarea presiunii intraoculare depinde și de tonusul vascular al segmentului anterior ocular, unele din substanţele recenzate ar putea prezenta și efecte hipotonizante oculare.

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Vasoconstrictor 5-HT receptors in the smooth muscle of the rat middle cerebral artery

Kovács

Hársing

Szénási

2012

European Journal of Pharmacology

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Functional serotonin and histamine receptor subtypes in porcine ciliary artery in comparison with middle cerebral artery

Cited by 5 publications

References 50 publications

Regulation of Human Umbilical Artery Contractility By Different Serotonin and Histamine Receptors

Regulation of Human Umbilical Artery Contractility By Different Serotonin and Histamine Receptors

The Role of Histamine and Serotonin in the Control of Vascular Motricity of the Anterior Ocular Segment - Review of the Literature from 1997 to 2018

Vasoconstrictor 5-HT receptors in the smooth muscle of the rat middle cerebral artery

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