Functional visceral fat activity evaluated by preoperative F‐18 <scp>FDG PET</scp>/<scp>CT</scp> predicts regional lymph node metastasis in differentiated thyroid cancer

Pahk, Kisoo; Choi, Sae Byeol; Kim, Sungeun

doi:10.1111/cen.13604

Cited by 11 publications

(26 citation statements)

References 20 publications

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“…VAT and SAT were identified in CT images based on predefined Hounsfield units (ranging from -70 to -110), as previously described [8,[19][20][21]. VAT was defined as the adipose tissue in the intra-abdominal fat region and SAT was defined as the adipose tissue in the extra-peritoneal fat region, between the skin and muscle.…”

Section: Image Analysismentioning

confidence: 99%

“…To determine the glucose uptake of the VAT, ROIs were selected on three consecutive slices of retroperitoneal VAT area, between the fourth and fifth lumbar vertebrae, and manually adjusted to exclude overspill 18 F-FDG uptake in the vessel, intestine, and/or muscle, as previously described [9,[19][20][21]. The highest SUVs and mean SUVs from the three consecutive ROIs were recorded and the averages defined as the SUVmax and SUVmean of the VAT, respectively.…”

Section: Suv ¼ Tracer Activity ðRoiþ ðMbq=mlþ=injected Dose ðMbqþ=totmentioning

confidence: 99%

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Characterization of glucose uptake metabolism in visceral fat by 18 F-FDG PET/CT reflects inflammatory status in metabolic syndrome

et al. 2020

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ObjectiveThe inflammatory activity of visceral adipose tissue (VAT) is elevated in metabolic syndrome (MS), and associated with vulnerability to atherosclerosis. Inflammation can be assessed by glucose uptake in atherosclerotic plaques. We investigated whether the glucose uptake of VAT, assessed by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT), is associated with systemic inflammatory status, and related to the number of MS components. Methods 18F-FDG PET/CT was performed in a total of 203 participants: 59 without MS component; M (0), 92 with one or two MS components; M(1-2), and 52 with MS. Glucose uptake in VAT was evaluated using the mean standardized uptake value (SUVmean) and the maximum SUV (SUVmax). Glucose uptakes of immune-related organs such as the spleen and bone marrow (BM) were evaluated using the SUVmax. ResultsVAT SUVmax correlated with high-sensitivity C-reactive protein (hsCRP) and the SUVmax of spleen and BM, which reflect the status of systemic inflammation. Both hsCRP and the SUVmax of the spleen and BM were higher in the MS group than in the M(1-2) or M(0) groups. In VAT, SUVmax increased with increasing number of MS components, while SUVmean decreased.

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Section: Image Analysismentioning

confidence: 99%

Section: Suv ¼ Tracer Activity ðRoiþ ðMbq=mlþ=injected Dose ðMbqþ=totmentioning

confidence: 99%

Characterization of glucose uptake metabolism in visceral fat by 18 F-FDG PET/CT reflects inflammatory status in metabolic syndrome

et al. 2020

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“…Subsequently, the arterial target-to-background ratio (TBR) was defined as averaged highest carotid artery SUV divided by averaged highest jugular vein SUV over all axial slices [16]. For the measurement of VAT area, VAT area was identified on CT images at the level of L4-L5 based on the predefined Hounsfield units (ranging from − 70 to − 110), as previously described [10][11][12][13]. ROI was manually drawn along the border of intra-abdominal fat.…”

Section: Image Analysismentioning

confidence: 99%

“…For the assessment of VAT glucose uptake, ROIs were placed on the targeted region and the maximum standardized uptake (SUVmax) was acquired. A total of 10 ROIs were located on VAT area and manually adjusted to exclude the overspill 18 F-FDG uptake in the muscle vessel, and/or intestine, as previously described [10][11][12][13]. VAT SUVmax was defined as the averaged SUVmax from those 10 ROIs.…”

Section: Image Analysismentioning

confidence: 99%

“…This concept has been well established by the study with atherosclerotic vulnerable plaques using 18 F-FDG PET/CT imaging [7][8][9]. Furthermore, increased glucose uptake of VAT evaluated by 18 F-FDG PET/CT has been found to be associated with tumor aggressiveness, for which upregulated VAT inflammation is a known risk factor [10][11][12]. Thus, 18 F-FDG PET/CT can be used as a surrogate marker for evaluation of VAT inflammation.…”

Section: Introductionmentioning

confidence: 98%

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Association of glucose uptake of visceral fat and acute myocardial infarction: a pilot 18F-FDG PET/CT study

Pahk

Kim

Joung

et al. 2020

Cardiovasc Diabetol

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Background Inflamed visceral adipose tissue (VAT) facilitates chronic inflammation in atherosclerotic lesions thereby leading to increased risk of coronary artery disease (CAD). In this study, we evaluated the glucose uptake of VAT and the carotid artery with 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) and their association with CAD, including acute myocardial infarction (AMI). Methods A total of 90 participants were enrolled (32 with AMI, 33 with chronic stable angina; CSA, and 25 control participants) and undertook 18F-FDG PET/CT. VAT glucose uptake was measured by using maximum standardized uptake value (SUVmax) of VAT region. The target-to-background ratio (TBR) of carotid artery was defined as the SUVmax of carotid artery divided by the SUVmax of jugular vein. The SUVmax of spleen, bone-marrow (BM), and high-sensitivity C-reactive protein (hsCRP) were used for the assessment of systemic inflammatory activity. Results VAT SUVmax was highest in participants with AMI, intermediate in participants with CSA, and lowest in control participants. Carotid artery TBR and systemic inflammatory surrogate markers including spleen SUVmax, BM SUVmax, and hsCRP were also higher in the AMI group than in the CSA or control group. Furthermore, VAT SUVmax showed significant positive correlation with carotid artery TBR, spleen SUVmax, BM SUVmax, and hsCRP. In multivariate linear regression and logistic regression analyses, VAT SUVmax was independently associated with carotid artery TBR and AMI. Conclusions Glucose uptake of VAT assessed by 18F-FDG PET/CT was associated with the severity of CAD and synchronized with the carotid artery inflammation in participants with CAD.

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Diagnostic role of F-18 FDG PET/CT for preoperative lymph node staging in thyroid cancer patients; A systematic review and metaanalysis

Kim

2020

Clinical Imaging

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Functional visceral fat activity evaluated by preoperative F‐18 FDG PET/CT predicts regional lymph node metastasis in differentiated thyroid cancer

Abstract: Functional visceral fat activity significantly affects the regional lymph node metastasis status in patients with differentiated thyroid cancer. Furthermore, it may also be useful to predict regional lymph node metastasis.

Cited by 11 publications

References 20 publications

Characterization of glucose uptake metabolism in visceral fat by 18 F-FDG PET/CT reflects inflammatory status in metabolic syndrome

Characterization of glucose uptake metabolism in visceral fat by 18 F-FDG PET/CT reflects inflammatory status in metabolic syndrome

Association of glucose uptake of visceral fat and acute myocardial infarction: a pilot 18F-FDG PET/CT study

Diagnostic role of F-18 FDG PET/CT for preoperative lymph node staging in thyroid cancer patients; A systematic review and metaanalysis

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