Functionalization of electrospun nanofiber for biomedical application

Chakrapani, Gayathri; Ramakrishna, Seeram; Zare, Mina

doi:10.1002/app.53906

Cited by 8 publications

(3 citation statements)

References 132 publications

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“…Solution blow spinning (SBS), a method rooted in gas-assisted fiber manufacturing technology, has garnered significant attention in recent years due to its high productivity and adaptability [69]. This approach proves particularly advantageous for spinning fibers from materials possessing low electrical conductivity, which poses challenges in the electrospinning process.…”

Section: Solution Blow Spinningmentioning

confidence: 99%

A Review on the Electrospinning of Polymer Nanofibers and Its Biomedical Applications

Venmathi Maran,

Jeyachandran,

Kimura

2024

J. Compos. Sci.

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Polymeric nanofibers have emerged as a captivating medium for crafting structures with biomedical applications. Spinning methods have garnered substantial attention in the context of medical applications and neural tissue engineering, ultimately leading to the production of polymer fibers. In comparison with polymer microfibers, polymer nanofibers boasting nanometer-scale diameters offer significantly larger surface areas, facilitating enhanced surface functionalization. Consequently, polymer nanofiber mats are presently undergoing rigorous evaluation for a myriad of applications, including filters, scaffolds for tissue engineering, protective equipment, reinforcement in composite materials, and sensors. This review offers an exhaustive overview of the latest advancements in polymer nanofiber processing and characterization. Additionally, it engages in a discourse regarding research challenges, forthcoming developments in polymer nanofiber production, and diverse polymer types and its applications. Electrospinning has been used to convert a broad range of polymers into nanoparticle nanofibers, and it may be the only approach with significant potential for industrial manufacturing. The basics of these spinning techniques, highlighting the biomedical uses as well as nanostructured fibers for drug delivery, disease modeling, regenerative medicine, tissue engineering, and bio-sensing have been explored.

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Section: Solution Blow Spinningmentioning

confidence: 99%

A Review on the Electrospinning of Polymer Nanofibers and Its Biomedical Applications

Venmathi Maran,

Jeyachandran,

Kimura

2024

J. Compos. Sci.

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“…[1][2][3][4][5] Core-sheath (often denoted as core-shell) fibers consisting of a core from one component surrounded by a sheath from another component are one of the most attractive fibers with complex architecture. 6,7 Having in mind application in biomedicine, cosmetics, and food packaging their main advantage is that the core and the sheath might be loaded selectively or separately with bioactive substances. 8 Thus, the complex composite fibers can offer a good platform for simultaneous or sequential delivery of bioactive agents of importance for certain applications.…”

Section: Introductionmentioning

confidence: 99%

Composite core‐double sheath fibers based on some biodegradable polyesters obtained by self‐organization during electrospinning

Kyuchyuk,

Paneva,

Manolova

et al. 2024

J of Applied Polymer Sci

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Obtaining core‐sheath fibers by single‐spinneret electrospinning is a recent and straightforward approach to prepare composite fibers. Fibers of more complex architecture consisting of poly(ethylene oxide) (PEO) core, inner poly(l‐lactide) sheath sd and outer beeswax (BW) sheath may also be obtained using this method. In the present study we report its applicability for a large series of (bio)degradable polyesters such as poly(ε‐caprolactone), poly(d,l‐lactide‐co‐glycolide), poly(butylene succinate), poly(3‐hydroxybutyrate), and poly(l‐lactide‐co‐d,l‐lactide). The fibers have a well‐differentiated PEO core, polyester inner sheath and BW outer sheath. The possibility for targeted location of hydrophilic or hydrophobic substances in the core or in the sheaths of the PEO/polyester/BW fibers has been demonstrated using nanosized zinc oxide with unmodified (hydrophilic) or silanized (hydrophobic) surface. PEO/polyester/BW fibrous materials loaded with a model drug (5‐nitro‐8‐hydroxyquinoline) exhibit antimicrobial activity. The obtained results show that single‐spinneret electrospinning is a novel and versatile method to prepare core‐double sheath composite fibers prospective for various applications such as biomedicine, cosmetics, and food packaging.

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“…This increase in sensitivity is secured mainly using nanofibers. Their characteristic structure with the immense number of pores [19][20][21] creates an enormous active surface that can be modified, enriched, or functionalized [22,23].…”

Section: Introductionmentioning

confidence: 99%

The Development of a Specific Nanofiber Bioreceptor for Detection of Escherichia coli and Staphylococcus aureus from Air

Varvařovská,

Kudrna,

Sopko

et al. 2024

Biosensors

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Polluted air and the presence of numerous airborne pathogens affect our daily lives. The sensitive and fast detection of pollutants and pathogens is crucial for environmental monitoring and effective medical diagnostics. Compared to conventional detection methods (PCR, ELISA, metabolic tests, etc.), biosensors bring a very attractive possibility to detect chemicals and organic particles with the mentioned reliability and sensitivity in real time. Moreover, by integrating nanomaterials into the biosensor structure, it is possible to increase the sensitivity and specificity of the device significantly. However, air quality monitoring could be more problematic even with such devices. The greatest challenge with conservative and sensing methods for detecting organic matter such as bacteria is the need to use liquid samples, which slows down the detection procedure and makes it more difficult. In this work, we present the development of a polyacrylonitrile nanofiber bioreceptor functionalized with antibodies against bacterial antigens for the specific interception of bacterial cells directly from the air. We tested the presented novel nanofiber bioreceptor using a unique air filtration system we had previously created. The prepared antibody-functionalized nanofiber membranes for air filtration and pathogen detection (with model organisms E. coli and S. aureus) show a statistically significant increase in bacterial interception compared to unmodified nanofibers. Creating such a bioreceptor could lead to the development of an inexpensive, fast, sensitive, and incredibly selective bionanosensor for detecting bacterial polluted air in commercial premises or medical facilities.

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Functionalization of electrospun nanofiber for biomedical application

Cited by 8 publications

References 132 publications

A Review on the Electrospinning of Polymer Nanofibers and Its Biomedical Applications

A Review on the Electrospinning of Polymer Nanofibers and Its Biomedical Applications

Composite core‐double sheath fibers based on some biodegradable polyesters obtained by self‐organization during electrospinning

The Development of a Specific Nanofiber Bioreceptor for Detection of Escherichia coli and Staphylococcus aureus from Air

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