Functionalization of gold nanoparticles with two aminoalcohol-based quinoxaline derivatives for targeting phosphoinositide 3-kinases (PI3Kα)

Araújo, Janine; Menezes, Fabrício G.; Silva, Heloiza F. O.; Vieira, Davi Serradella; Silva, Sérgio Ruschi Bergamachi; Bortoluzzi, Adaílton J.; Sant’Anna, Celso; Eugênio, Mateus; Neri, Jannyely M.; Gasparotto, Luiz H. S.

doi:10.1039/c8nj04314k

Cited by 10 publications

(2 citation statements)

References 63 publications

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“…One study showed that GNPs were easily functionalized using 2,3-diethanolminoquinoxaline (DEQX) and 2-(2,3-dihydro- [1,4] oxazino [2,3- b] quinoxaline -4-yl) ethanol (OAQX). They used these conjugates to target cancer cells, because compounds with a quinoxaline motif can bind to phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) and these enzymes are overexpressed in some types of neoplasms ( Araújo et al, 2019 ). Quinoxaline derivatives have also been used to functionalize silver and gadolinium-based nanoparticles and were shown to give excellent stability, while providing functional groups such as -NH 2 or -OH, which could serve for the binding of different ligands ( Morlieras et al, 2013 ; Neri et al, 2021 ).…”

Section: Functionalization Methodsmentioning

confidence: 99%

Latest Trends in Lateral Flow Immunoassay (LFIA) Detection Labels and Conjugation Process

Mirica

Stan²,

Chelcea³

et al. 2022

Front. Bioeng. Biotechnol.

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LFIA is one of the most successful analytical methods for various target molecules detection. As a recent example, LFIA tests have played an important role in mitigating the effects of the global pandemic with SARS-COV-2, due to their ability to rapidly detect infected individuals and stop further spreading of the virus. For this reason, researchers around the world have done tremendous efforts to improve their sensibility and specificity. The development of LFIA has many sensitive steps, but some of the most important ones are choosing the proper labeling probes, the functionalization method and the conjugation process. There are a series of labeling probes described in the specialized literature, such as gold nanoparticles (GNP), latex particles (LP), magnetic nanoparticles (MNP), quantum dots (QDs) and more recently carbon, silica and europium nanoparticles. The current review aims to present some of the most recent and promising methods for the functionalization of the labeling probes and the conjugation with biomolecules, such as antibodies and antigens. The last chapter is dedicated to a selection of conjugation protocols, applicable to various types of nanoparticles (GNPs, QDs, magnetic nanoparticles, carbon nanoparticles, silica and europium nanoparticles).

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Section: Functionalization Methodsmentioning

confidence: 99%

Latest Trends in Lateral Flow Immunoassay (LFIA) Detection Labels and Conjugation Process

Mirica

Stan²,

Chelcea³

et al. 2022

Front. Bioeng. Biotechnol.

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“…In the past few decades, design and characterisations of heterocyclic organic compounds have received considerable attention because of their pivotal role and wide application in different areas of life science . Particularly, nitrogen‐containing heterocyclic systems are known to exhibit excellent pharmacological activities .…”

Section: Introductionmentioning

confidence: 99%

A newly synthesized nitrogen‐rich derivative of bicyclic quinoxaline—Structural and conceptual DFT reactivity study

Abad¹,

Hajji

Ramli

et al. 2020

J of Physical Organic Chem

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Novel nitrogen-rich compound featured bicyclic quinoxaline as a basic core structure has been synthesized, 1-{[1-(3-azido-2-hydroxypropyl)-1H-1,-2,3-triazol-4-yl]methyl}-3-methyl-1,2-dihydroquinoxalin-2-one with formula C 15 H 16 N 8 O 2 , and their structural and chemical reactivity aspects have been comprehensively discussed. Nature, role, and relative contribution of weak noncovalent interactions in supramolecular assembly have been assessed through single-crystal analysis and computational approaches. Useful information about the global and local reactivity were obtained from Conceptual Density Functional Theory at wB97X-D/cc-pVDZ level. Studied system could act as strong electrophile and/or moderate nucleophile in polar organic reactions. We hope this study will provide deeper insight in the knowledge of the synthesis and chemistry of the quinoxaline and quinoxaline derivatives. K E Y W O R D SDFT, chemical reactivity theory, Hirshfeld surfaces, NCI topological analysis, quinoxaline derivatives, weak noncovalent interactions

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Quinoxaline-based chromogenic and fluorogenic chemosensors for the detection of metal cations

2021

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Functionalization of gold nanoparticles with two aminoalcohol-based quinoxaline derivatives for targeting phosphoinositide 3-kinases (PI3Kα)

Abstract: Quinoxaline derivatives have attracted considerable attention due to their vast range of applications that includes electroluminescence and biomedicine.

Cited by 10 publications

References 63 publications

Latest Trends in Lateral Flow Immunoassay (LFIA) Detection Labels and Conjugation Process

Latest Trends in Lateral Flow Immunoassay (LFIA) Detection Labels and Conjugation Process

A newly synthesized nitrogen‐rich derivative of bicyclic quinoxaline—Structural and conceptual DFT reactivity study

Quinoxaline-based chromogenic and fluorogenic chemosensors for the detection of metal cations

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