Functionalization of phosphocalcic bioceramics for bone repair applications

Damia, Chantal; Marchat, David; Lemoine, Charly; Douard, Nathalie; Chaleix, Vincent; Sol, Vincent; Larochette, Nathanaël; Logeart-Avramoglou, Delphine; Brie, Joël; Champion, Éric

doi:10.1016/j.msec.2018.01.008

Cited by 25 publications

(20 citation statements)

References 81 publications

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“…They are used to get information on the constituent elements, organic modifiers and chemical composition of the surface after functionalization [17]. In parallel, thermogravimetry analyses (TGA) coupled with mass spectroscopy (MS) are employed for the study of the interaction strength between the attached organic groups and the surface and estimate the quantity of immobilized molecules [28]. However, none of them give an overview of the chemistry of the substrate surface, i.e., spatial repartition and coverage of the ceramic surface by organosilane molecules.…”

Section: Introductionmentioning

confidence: 99%

Functionalization of Hydroxyapatite Ceramics: Raman Mapping Investigation of Silanization

et al. 2019

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Surface modification of bioceramic materials by covalent immobilization of biomolecules is a promising way to improve their bioactivity. This approach implies the use of organic anchors to introduce functional groups on the inorganic surface on which the biomolecules will be immobilized. In this process, the density and surface distribution of biomolecules, and in turn the final biological properties, are strongly influenced by those of the anchors. We propose a new approach based on Raman 2D mapping to evidence the surface distribution of organosilanes, frequently used as anchors on biomaterial surfaces on hydroxyapatite and silicated hydroxyapatite ceramics. Unmodified and silanized ceramic surfaces were characterized by means of contact angle measurements, atomic force microscopy (AFM) and Raman mapping. Contact angle measurements and AFM topographies confirmed the surface modification. Raman mapping highlighted the influence of both the ceramic’s composition and silane functionality (i.e., the number of hydrolysable groups) on the silane surface distribution. The presence of hillocks was shown, evidencing a polymerization and/or an aggregation of the molecules whatever the silane and the substrates were. The substitution of phosphate groups by silicate groups affects the covering, and the spots are more intense on SiHA than on HA.

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Section: Introductionmentioning

confidence: 99%

Functionalization of Hydroxyapatite Ceramics: Raman Mapping Investigation of Silanization

et al. 2019

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“…As an ionic material HAP show specific surface properties [4,5] that favours the accommodation of a large variety of molecules that can be used for inducing specific medical responses [6].…”

Section: Introductionmentioning

confidence: 99%

Modification of hydroxyapatite surface properties by electron irradiation

Bai

Hornez

Maschke

et al. 2020

Radiation Physics and Chemistry

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In the present work, the modification of wetting properties of EB irradiated HA ceramics are studied under air and N2 gas atmospheres. We show a noticeable increase of the hydrophily of electron irradiated HA ceramics in an air atmosphere and a lesser increase when the samples are irradiated in an N2 atmosphere, such a phenomenon is correlated to a modification of grain morphology obtained under the two atmospheres. With a progressive water saturation of the ceramics, the wetting angles increase progressively until they reach a plateau value different from each set of samples (irradiated under air, irradiated under N2 atmosphere and pristine).Profilometry, SEM/EDX, XRD and Raman spectrometry analysis do not show differences between irradiated and pristine samples which indicates that the EB irradiation modifies the surface chemical elements related to the surface wetting properties and not those analysed by the above techniques.

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“…Researchers have found that polycaprolactone (PCL)/PLGA scaffold blended with tri-calcium phosphate (TCP) by solid freeform fabrication technology can enhance the mechanical strength of the scaffold [10]. These scaffolds, however, are lack of carriers to load and sustained-release osteoinductive growth factor [11]. Due to their biocompatibility and osteoconductive properties, apatite cement (such as calcium phosphate cement, CPC) represent a promising candidate material for bone substitution.…”

Section: Introductionmentioning

confidence: 99%

“…Due to their biocompatibility and osteoconductive properties, apatite cement (such as calcium phosphate cement, CPC) represent a promising candidate material for bone substitution. Many animal studies showed that PLGA microspheres embedded within CPC increases cement degradation and enhances osteogenesis [11,12]. However, the osteoconductive properties of CPC/PLGA are not sufficient to achieve complete defect filling [13].…”

Section: Introductionmentioning

confidence: 99%