Functionalized aliphatic polyketones with germicide activity

Araya-Hermosilla, Esteban; Parlanti, Paola; Gemmi, Mauro; Mattoli, Virgilio; Pietro, Sebastiano Di; Iacopini, Dalila; Granchi, Carlotta; Turchi, Barbara; Fratini, Filippo; Bussolo, Valeria Di; Minutolo, Filippo; Picchioni, Francesco; Pucci, Andrea

doi:10.1039/d2ra06396d

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Even though few works have been published in the literature on the preparation of postfunctionalized PK, data reported in the literature demonstrate their high potential as supports for different types of enzymes [72], germicide polymeric coatings [ 73] or as scaffolds for urothelial cells [56].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

Rampazzo,

Vavasori,

Ronchin

et al. 2024

Preprint

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Today, polymeric Drug Delivery Systems (DDS) appear as an interesting solution against bacterial resistance, having great advantages such as low toxicity, biocompatibility, and biodegradability. In this work, two polyketones (PK) have been post-functionalized with taurinate (PKT) or sulfanilate (PKSK) and employed as biocompatible carriers for Vancomycin against bacterial infections. Mod-ified PKs were easily prepared by Paal-Knorr reaction and loaded with Vancomycin at variable pH. All polymers were characterized by FT-IR, DSC, TGA, SEM and elemental analysis. Antimicrobial activity was tested against Gram positive Staphylococcus aureus ATCC 25923 and correlated to the different pH used for its loading (between 2.3 and 8.8). Distinctively, minimum inhibitory con-centrations achieved with PKT and PKSK loaded with Vancomycin are similar, 0.23μg/mL and 0.24μg/mL respectively, i.e. six times lower that Vancomycin alone. The use of post-functionalized aliphatic polyketones has thus been demonstrated to be a promising way to obtain very efficient polymeric DDS.

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Section: Introductionmentioning

confidence: 99%

Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

Rampazzo,

Vavasori,

Ronchin

et al. 2024

Preprint

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Effect of intermolecular interactions on the glass transition temperature of chemically modified alternating polyketones

González Cortes,

Araya-Hermosilla,

Wrighton-Araneda

et al. 2023

Materials Today Chemistry

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Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

Rampazzo,

Vavasori,

Ronchin

et al. 2024

Polymers

View full text Add to dashboard Cite

Today, polymeric drug delivery systems (DDS) appear as an interesting solution against bacterial resistance, having great advantages such as low toxicity, biocompatibility, and biodegradability. In this work, two polyketones (PK) have been post-functionalized with sodium taurinate (PKT) or potassium sulfanilate (PKSK) and employed as carriers for Vancomycin against bacterial infections. Modified PKs were easily prepared by the Paal–Knorr reaction and loaded with Vancomycin at a variable pH. All polymers were characterized by FT-IR, DSC, TGA, SEM, and elemental analysis. Antimicrobial activity was tested against Gram-positive Staphylococcus aureus ATCC 25923 and correlated to the different pHs used for its loading (between 2.3 and 8.8). In particular, the minimum inhibitory concentrations achieved with PKT and PKSK loaded with Vancomycin were similar, at 0.23 μg/mL and 0.24 μg/mL, respectively, i.e., six times lower than that with Vancomycin alone. The use of post-functionalized aliphatic polyketones has thus been demonstrated to be a promising way to obtain very efficient polymeric DDS.

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Functionalized aliphatic polyketones with germicide activity

Abstract: Surfaces coated by polyketones bearing quaternary ammonium compounds showed excellent bactericidal properties with antibacterial rate of 99%.

Cited by 3 publications

References 27 publications

Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

Effect of intermolecular interactions on the glass transition temperature of chemically modified alternating polyketones

Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

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