Functionalized azobenzene platinum(II) complexes as putative anticancer compounds

Samper, Katia G.; Lorenzo, Júlia; Capdevila, Mercè; Palacios, Òscar; Bayón, Pau

doi:10.1007/s00775-021-01865-9

Cited by 2 publications

(2 citation statements)

References 59 publications

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“…However, the suggested application is dermal and the substance is proposed to be solved in an agar base. Moreover, other medical applications of azobenzene derivatives have been recently suggested [ 21 ]. The plaster should fulfil several requirements, such as the antibacterial action, nutrition, and moistening of the infected lesion, facilitating the formation of granulation tissue.…”

Section: Resultsmentioning

confidence: 99%

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Antimicrobial and Antibiofilm Effect of 4,4′-Dihydroxy-azobenzene against Clinically Resistant Staphylococci

et al. 2022

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The spread of antibiotic resistance among human and animal pathogens is one of the more significant public health concerns. Moreover, the restrictions on the use of particular antibiotics can limit the options for the treatment of infections in veterinary clinical practice. In this context, searching for alternative antimicrobial substances is crucial nowadays. In this study, 4,4′-dihydroxy-azobenzene (DHAB) was tested for its potential in vitro as an antimicrobial agent against two relevant human and animal pathogens, namely Staphylococcus aureus and Staphylococcus pseudintermedius. The values of minimal inhibitory concentration (MIC) were 64 and 32 mg/L respectively, and they comparable to other azo compounds of probed antimicrobial activity. In addition, the minimal bactericidal concentrations (MCB) were 256 and 64 mg/L. The mechanism by which DHAB produces toxicity in staphylococci has been investigated. DHAB caused membrane damage as revealed by the increase in thiobarbituric acid reactive substances (TBARS) such as malondialdehyde. Furthermore, differential induction of the enzymes peroxidases and superoxide dismutase in S. aureus and S. pseudintermedius suggested their prevalent role in ROS-scavenging due to the oxidative burst induced by this compound in either species. In addition, this substance was able to inhibit the formation of biofilms by both bacteria as observed by colorimetric tests and scanning electron microscopy. In order to assess the relevance of DHAB against clinical strains of MRSA, 10 clinical isolates resistant to either methicillin or daptomycin were assayed; 80% of them gave values of CMI and CMB similar to those of the control S. aureus strain. Finally, cutaneous plasters containing a composite formed by an agar base supplemented with DHAB were designed. These plasters were able to inhibit in vitro the growth of S. aureus and S. pseudintermedius, particularly the later, and this suggests that this substance could be a promising candidate as an alternative to antibiotics in the treatment of animal skin infections, as it has been proven that the toxicity of this substance is very low particularly at a dermal level.

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Section: Resultsmentioning

confidence: 99%

“…Moreover, they have multiple biomedical applications [ 20 , 21 , 22 ]. In this sense, in the second quarter of the 20th century, the antimicrobial properties of azo dyes were discovered [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antibiofilm Effect of 4,4′-Dihydroxy-azobenzene against Clinically Resistant Staphylococci

et al. 2022

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Light-Controlled Anticancer Activity and Cellular Uptake of a Photoswitchable Cisplatin Analogue

Stolarek,

Kaminski,

Kaczor-Kamińska

et al. 2024

J. Med. Chem.

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A photoactive analogue of cisplatin was synthesized with two arylazopyrazole ligands, able to undergo trans−cis/cis− trans photoisomerizations. The cis photoisomer showed a dark halflife of 9 days. The cytotoxicities of both photoisomers of the complex were determined in several cancer and normal cell lines and compared to that of cisplatin. The trans photoisomer of the complex was much more cytotoxic than both the cis photoisomer and cisplatin, and was more toxic for cancer (4T1) than for normal (NMuMG) murine breast cells. 4T1 cell death occurred through necrosis. Photoisomerization of the trans and cis photoisomers internalized by the 4T1 cells increased and decreased their viability, respectively. The cellular uptake of the trans photoisomer was stronger than that of both the cis photoisomer and cisplatin. Both photoisomers interacted with DNA faster than cisplatin. The trans photoisomer was bound stronger by bovine serum albumin and induced a greater decrease in cellular glutathione levels than the cis photoisomer.

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Functionalized azobenzene platinum(II) complexes as putative anticancer compounds

Cited by 2 publications

References 59 publications

Antimicrobial and Antibiofilm Effect of 4,4′-Dihydroxy-azobenzene against Clinically Resistant Staphylococci

Antimicrobial and Antibiofilm Effect of 4,4′-Dihydroxy-azobenzene against Clinically Resistant Staphylococci

Light-Controlled Anticancer Activity and Cellular Uptake of a Photoswitchable Cisplatin Analogue

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