Functionalized carbon nanotube electrodes for controlled DNA sequencing

Abstract

In the last decade, solid-state nanopores/nanogaps have attracted significant interest in the rapid detection of DNA nucleotides. However, reducing the noise through the controlled translocating of the DNA nucleobases...

Identifying DNA Nucleotides via Transverse Electronic Transport in Atomically Thin Topologically Defected Graphene Electrodes

“…16,17,42 However, decreasing the noise ratios through controlled translocation is a crucial problem for the emerging nanopore-based DNA sequencing technique to attain single-nucleotide resolution at the molecular level. 16,17,30 More importantly, graphene-based pore very rapidly exhibit clogging of the pore due to strong interaction, leading to pore blockage, yielding irreversible-poreclosure, and sticking. 5,43 Therefore, nanogap based concepts have been proposed in place of nanopores.…”

“…44−46 However, noise ratios and strong electrostatic interaction in experiments have stuck its use in practical nanogap-based devices for DNA sequencing. 7,16,17,30,47 As an alternative, topologically extended-linedefects in graphene (ELDG) nanoscale sized sheet could be utilized, which has been recently synthesized by Lahiri and coworkers. 48−51 The ELDG is molded by combining octagons (o) and a pair of pentagon (p) carbon rings (sp 2 -hybridized) embedded in a pure graphene nanosheet.…”

“…The developments of nanoscale-sized DNA sequencing device techniques have advanced in recent years to reduce the sequencing cost of a whole-genome. − In this regard, various techniques have been developed, such as DNA sequencing with solid-state nanopores, − ,− nanogaps, ,− and nanochannels. − Solid-state nanopores have attracted much attention for third-generation DNA sequencing technology. − ,− , Such nanopore-based devices have been presaged as a possible technique of providing inexpensive and accurate human whole-genome sequencing by determining either ion-current as DNA passes through the nanoscale-sized pore or by electronic transverse-conductance and tunnelling currents across the pore itself. ,− In 2010, three independent experimental...…”

Molecular Organization of Functionalized Carbon Nanotube at the Water-Air Interface and in Solid Thin Film

“…Despite being poorly soluble, CNTs can be altered or functionalized to interact better with other chemical groups, enabling its processing through thin film techniques, in-situ analysis, and electrical measurements or spectroscopic analysis. From that, the behavior of the material under tension, electrical or optical stimulus is obtained 7 . Thus, it is compelling to use a number of techniques to investigate the properties of carbon nanotubes, whether it is to characterize or apply them to rising technologies.…”

Extended topological line defects in graphene for individual identification of DNA nucleobases

“…b ) is the transmission function of the electrons entering at energy (E) from L to R lead under applied bias voltage (V b ), f (E À m L,R ) denotes the Fermi-Dirac distribution function of electrons in the L/R leads and m L,R is the chemical potential where m L,R= E F AE V b /2 are stimulated correspondingly up/down according to the Fermi-energy E F 62,63. …”