Functionalized carbon nanotubes as emerging delivery system for the treatment of cancer

Mahajan, Shubhangi; Patharkar, Abhimanyu; Kuche, Kaushik; Maheshwari, Rahul; Deb, Pran Kishore; Kalia, Kiran; Tekade, Rakesh K.

doi:10.1016/j.ijpharm.2018.07.027

Cited by 131 publications

(63 citation statements)

References 140 publications

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“…Previous studies have declared that owing to their excellent surface properties, CNT are smart nano-carries for the delivery of drugs, genes and other biomedically essential materials into the cells with high biocompatibility [16]. Apart from its inimitable cell penetration aptitude, CNTs have proven to be suitable in specific and targeted drug delivery to desired cancerous tissues [24]. It is worth to mention that the successful formation of ZnO/CNT@Fe 3 O 4 nanocomposite was further characterized using UV-spectroscopy, FTIR, SEM, and XRD.…”

Section: Discussionmentioning

confidence: 99%

ZnO/CNT@Fe ₃ O ₄ induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment

Yousefi

Safaroghli‐Azar

Fakhroueian

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Section: Discussionmentioning

confidence: 99%

ZnO/CNT@Fe ₃ O ₄ induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment

Yousefi

Safaroghli‐Azar

Fakhroueian

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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“…RMSD and RMSF analyses also confirmed the simulation stability. [30], [70]- [72]. It seems that the application of these nanostructures (especially P-CNTs) to carry PD drugs can be an attractive topic for future studies.…”

Section: 3α-synuclein Protein Particles Contact Areamentioning

confidence: 99%

Potential Treatment of Parkinson's Disease, Using Last-Generation Carbon Nanotubes: A Bimolecular In-Silico Study

Alimohammadi

Nikzad

Khedri

et al. 2020

Preprint

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Background: Parkinson's disease (PD) is one of the most common neurodegenerative disorders. One of the underlying mechanisms of the disease is the accumulation of α-synuclein protein aggregates, including amyloids and Lewy bodies in the brain, resulting in the death of dopaminergic cells in the substantia nigra. The current treatments for PD are mainly focused on replacing dopamine. However, if these medications are stopped, the severity of PD will increase. Moreover, the drugs used for the treatment of PD are associated with considerable side effects and dietary restrictions. Therefore, necessary studies to develop more effective medications for PD seem to be indispensable. To prevent the progression of PD, avoiding the development of α-synuclein amyloids could be proposed. Methods: In this study, the effects of three last-generation nanotube-based structures on α-synuclein amyloid formation were investigated for the first time employing Molecular Dynamics (MD) simulation tools. Molecular dynamics provide a deep insight into atomic interactions and can well study α-synuclein amyloid formation at the atomic and molecular scales.Results: The molecular study results indicated that all of the nanotubes studied in this work, had strong energy interactions with α-synuclein. Therefore, nanotubes using phosphorus, nitrogen and boron dopants, have great potential to prevent α-synuclein amyloid formation. Among these nanotubes, phosphorus-doped carbon nanotube (P-CNT) has the most substantial interactions with α-synuclein. The P-CNT caused more hydrogen bonds to be formed between water and α-synuclein molecules. This phenomenon leads to a decrease in the compactness, stability, and contact area of α-synuclein proteins, which results in considerable changes in the secondary structure of α-synuclein.Conclusions: Doping nanotubes especially P-CNT could be very effective for preventing the α-synuclein amyloid formation and hence, halting the progression of PD. This molecular study paves the way for the use of the Doping nanotubes in the treatment of PD. These structures are highly tunable and flexible. Therefore, the results of this work can be developed to computational, experimental and clinical levels.

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“…Briefly, HeLa cell was incubated in 96-well plate overnight to reach 50% confluences. Subsequently, HeLa cells were co-incubated with RGDfC-Se@siNC or RGDfC-Se@siRNA (different siRNA concentration) for 48 h. Finally, HeLa cells were processed as previously reported (Mahajan et al, 2018).…”

Section: Mtt Assaymentioning

confidence: 99%

Functionalized selenium nanoparticles for targeted siRNA delivery silence Derlin1 and promote antitumor efficacy against cervical cancer

et al. 2019

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2020) Functionalized selenium nanoparticles for targeted siRNA delivery silence Derlin1 and promote antitumor efficacy against cervical cancer, Drug Delivery, 27:1, 15-25, ABSTRACT Small interfering RNA (siRNA) exhibits great potential as a novel therapeutic option due to its highly sequence-specific ability to silence genes. However, efficient and safe delivery carriers are required for developing novel therapeutic paradigms. Thus, the successful development of efficient delivery platforms for siRNA is a crucial issue for the development of siRNA-based drugs in cancer treatments. In this study, biocompatible selenium nanoparticles (SeNPs) were loaded with RGDfC peptide to fabricate tumor-targeting gene delivery vehicle RGDfC-SeNPs. Subsequently, RGDfC-SeNPs were loaded with Derlin1-siRNA to fabricate RGDfC-Se@siRNA, which are functionalized selenium nanoparticles. RGDfC-Se@siRNA showed greater uptake in HeLa cervical cancer cells in comparison with that in human umbilical vein endothelial cells (HUVECs), verifying the RGDfC-mediated specific uptake of RGDfC-Se@siRNA. RGDfC-Se@siRNA was capable of entering HeLa cells via clathrin-associated endocytosis, and showed faster siRNA release in a cancer cell microenvironment in comparison with a normal physiological environment. qPCR and western blotting assays both indicated that RGDfC-Se@siRNA exhibited an obvious gene silencing efficacy in HeLa cells. RGDfC-Se@siRNA suppressed the invasion, migration and the proliferation of HeLa cells, and triggered HeLa cell apoptosis. Moreover, RGDfC-Se@siRNA induced the disruption of mitochondrial membrane potentials. Meanwhile, RGDfC-Se@siRNA enhanced the generation of reactive oxygen species (ROS) in HeLa cell, suggesting that mitochondrial dysfunction mediated by ROS might play a significant role in RGDfC-Se@siRNA-induced apoptosis. Interestingly, RGDfC-SeNPs@siRNA exhibited significant antitumor activity in a HeLa tumor-bearing mouse model. Additionally, RGDfC-SeNPs@siRNA is nontoxic to main organ of mouse. The above results indicate that RGDfC-Se@siRNA provides a promising potential for cervical cancer therapy. ARTICLE HISTORY

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Functionalized carbon nanotubes as emerging delivery system for the treatment of cancer

Cited by 131 publications

References 140 publications

ZnO/CNT@Fe ₃ O ₄ induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment

ZnO/CNT@Fe ₃ O ₄ induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment

Potential Treatment of Parkinson's Disease, Using Last-Generation Carbon Nanotubes: A Bimolecular In-Silico Study

Functionalized selenium nanoparticles for targeted siRNA delivery silence Derlin1 and promote antitumor efficacy against cervical cancer

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Functionalized carbon nanotubes as emerging delivery system for the treatment of cancer

Cited by 131 publications

References 140 publications

ZnO/CNT@Fe 3 O 4 induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment

ZnO/CNT@Fe 3 O 4 induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment

Potential Treatment of Parkinson's Disease, Using Last-Generation Carbon Nanotubes: A Bimolecular In-Silico Study

Functionalized selenium nanoparticles for targeted siRNA delivery silence Derlin1 and promote antitumor efficacy against cervical cancer

Contact Info

Product

Resources

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ZnO/CNT@Fe ₃ O ₄ induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment

ZnO/CNT@Fe ₃ O ₄ induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment