Functionalized extracellular nanovesicles as advanced CRISPR delivery systems

Wang, Siqing; Kong, Huimin; Zhuo, Chenya; Liu, Li; Lv, Shixian; Cheng, Du; Lao, Yeh-Hsing; Tao, Yu; Li, Mingqiang

doi:10.1039/d4bm00054d

Biomater. Sci.

2024

DOI: 10.1039/d4bm00054d

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Functionalized extracellular nanovesicles as advanced CRISPR delivery systems

Siqing Wang,

Huimin Kong,

Chenya Zhuo

et al.

Abstract: The clustered regularly interspaced short palindromic repeat (CRISPR) system, an emerging tool for genome editing, has garnered significant public interest for its potential in treating genetic diseases. Despite the rapid...

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Cited by 2 publications

References 146 publications

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Harnessing Gene Editing Technology for Tumor Microenvironment Modulation: An Emerging Anticancer Strategy

Feng,

Zhang,

Wang

et al. 2024

Chemistry A European J

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Cancer is a multifaceted disease influenced by both intrinsic cellular traits and extrinsic factors, with the tumor microenvironment (TME) being crucial for cancer progression. To satisfy their high proliferation and aggressiveness, cancer cells always plunder large amounts of nutrients and release various signals to their surroundings, forming a dynamic TME with special metabolic, immune, microbial and physical characteristics. Due to the neglect of interactions between tumor cells and the TME, traditional cancer therapies often struggle with challenges such as drug resistance, low efficacy, and recurrence. Importantly, the development of gene editing technologies, particularly the CRISPR‐Cas system, offers promising new strategies for cancer treatment. Combined with nanomaterial strategies, CRISPR‐Cas technology exhibits precision, affordability, and user‐friendliness with reduced side effects, which holds great promise for profoundly altering the TME at the genetic level, potentially leading to lasting anticancer outcomes. This review will delve into how CRISPR‐Cas can be leveraged to manipulate the TME, examining its potential as a transformative anticancer therapy.

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Harnessing Gene Editing Technology for Tumor Microenvironment Modulation: An Emerging Anticancer Strategy

Feng,

Zhang,

Wang

et al. 2024

Chemistry A European J

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Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis

Yuan,

Li,

Chen

et al. 2024

Journal of Controlled Release

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Functionalized extracellular nanovesicles as advanced CRISPR delivery systems

Abstract: The clustered regularly interspaced short palindromic repeat (CRISPR) system, an emerging tool for genome editing, has garnered significant public interest for its potential in treating genetic diseases. Despite the rapid...

Cited by 2 publications

References 146 publications

Harnessing Gene Editing Technology for Tumor Microenvironment Modulation: An Emerging Anticancer Strategy

Harnessing Gene Editing Technology for Tumor Microenvironment Modulation: An Emerging Anticancer Strategy

Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis

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