Functionalized graphene oxide/Fe3O4 nanocomposite: A biocompatible and robust nanocarrier for targeted delivery and release of anticancer agents

Taheri‐Kafrani, Asghar; Shirzadfar, Hamidreza; Kajani, Abolghasem Abbasi; Kudhair, Bassam K.; Mohammed, Layth Jasim; Mohammadi, Shima; Lotfi, Fatemeh

doi:10.1016/j.jbiotec.2021.03.005

Cited by 27 publications

(13 citation statements)

References 34 publications

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“…The saturation magnetism of Fe 3 O 4 and Fe 3 O 4 @GO is 76.06 mg/g and 26.017 emu/g, respectively, which is lower than the reported amount for Fe, that is, 92 emu/g, which is due to the much smaller amount of magnetite nanoparticles and the lower content of Fe in the hybrid. [64,[66][67][68] In other words, the reduction in M s to a smaller size can be ascribed to the surface-specific effects of these nanoparticles. The surface of the nanoparticles is composed of upside-down or irregular spins that prevent the nucleus from rotating in the direction of the field, which results in the reduction in the saturation magnetism of the small particles.…”

Section: Morphological and Structural Characterization Of Go And Go@f...mentioning

confidence: 99%

Glucosamine conjugated iron oxide and graphene oxide nanohybrid for smart drug delivery

et al. 2023

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Smart drug delivery systems have attracted a lot of attention as one of the new treatment methods for cancer. In this study, a smart drug delivery system carrying anticancer drugs was obtained by the intelligent synthesis of glucosamine (GA)‐functionalized graphene oxide (GO)‐based iron oxide nanoparticles (Fe3O4@GO‐GA) using Hummers and chemical co‐precipitation processes. Nanohybrids have a high surface area (280.26 m2/g) and superparamagnetic behaviour (Ms = 26.017 emu/g), indicating a significant loading capacity (373.78 mg/mg) and efficiency (96.3%) for pharmaceutical loading. An adsorption study of conventional daunorubicin (DNR) on this carrier showed that the drug release is more prone to occur under acidic conditions (pH = 5.5), at moderately high temperatures (T = 40°C), and in the absence of smart carriers. The toxicity of the smart nanohybrids was examined using the sulphorhodamine B (SRB) assay in Michigan Cancer Foundation‐7 (MCF‐7) cell lines. The rate of death of cells exposed to smart drug‐containing systems in comparison to the systems without GA shows that GA reduces the toxicity of Fe3O4@GO.

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Section: Morphological and Structural Characterization Of Go And Go@f...mentioning

confidence: 99%

Glucosamine conjugated iron oxide and graphene oxide nanohybrid for smart drug delivery

et al. 2023

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“…), organic (carbon, lipids, proteins, exosomes, etc . ), and composites (composites, hybrids, and core–shell NPs), have been developed and used for various biomedical applications. ,, The most commonly used NPs for the detection, imaging, and treatment of cancers are discussed.…”

Section: Classification Of Npsmentioning

confidence: 99%

Recent Advances in Nanomaterials Development for Nanomedicine and Cancer

Kajani

Javanmard

Asadnia

et al. 2021

ACS Appl. Bio Mater.

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Cancer is considered one of the leading causes of death, with a growing number of cases worldwide. However, the early diagnosis and efficient therapy of cancer have remained a critical challenge. The emergence of nanomedicine has opened up a promising window to address the drawbacks of cancer detection and treatment. A wide range of engineered nanomaterials and nanoplatforms with different shapes, sizes, and composition has been developed for various biomedical applications. Nanomaterials have been increasingly used in various applications in bioimaging, diagnosis, and therapy of cancers. Recently, numerous multifunctional and smart nanoparticles with the ability of simultaneous diagnosis and targeted cancer therapy have been reported. The multidisciplinary attempts led to the development of several exciting clinically approved nanotherapeutics. The nanobased materials and devices have also been used extensively to develop point-of-care and highly sensitive methods of cancer detection. In this review article, the most significant achievements and latest advances in the nanomaterials development for cancer nanomedicine are critically discussed. In addition, the future perspectives of this field are evaluated.

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“…The magnetic target methods have been extensively investigated by researchers in vivo and vitro [ 27 , 28 , 29 ]. Additionally, it has been used as a magnetic resonance image (MRI) contrast agent for early diagnosis and real-time monitoring tumor therapy [ 30 , 31 , 32 ]. Thus, endowing ND with magnetism properties is extremely attractive [ 31 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Multi-Stimuli Responsive Fe3O4 Coated with Diamonds Nanocomposite for Magnetic Assisted Chemo-Photothermal Therapy

Kong

Zhao

et al. 2023

Molecules

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Nanodiamonds with magnetic resonance imaging (MRI) and targeted drug delivery to exert combined effects for biomedical applications have been considered to be an urgent challenge. Herein, a novel bio-nanoarchitectonics(Fe3O4@NDs) with simultaneous imaging and therapeutic capacities was fabricated by covalently conjugating nanodiamonds (NDs) with Fe3O4. Fe3O4@NDs exhibited better biocompatibility and excellent photothermal stability with superb photothermal conversion performance (37.2%). Fe3O4@NDs has high doxorubicin (DOX) loading capacity (193 mg/g) with pH and NIR-responsive release characteristics. Fe3O4@NDs loading DOX showed a combined chemo-photothermal inhibitory effect on the tumor cells. Enhanced T2-weighted MRI contrast toward the tumor, with the assistance of a magnetic field, convinced the Fe3O4@NDs gathered in the tumor more efficiently and could be used for MRI-based cancer diagnosis. Our results revealed an effective strategy to achieve a stimuli-sensitive nanoplatform for multifunctional theranostics by the combined action.

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Functionalized graphene oxide/Fe3O4 nanocomposite: A biocompatible and robust nanocarrier for targeted delivery and release of anticancer agents

Cited by 27 publications

References 34 publications

Glucosamine conjugated iron oxide and graphene oxide nanohybrid for smart drug delivery

Glucosamine conjugated iron oxide and graphene oxide nanohybrid for smart drug delivery

Recent Advances in Nanomaterials Development for Nanomedicine and Cancer

Synthesis of Multi-Stimuli Responsive Fe3O4 Coated with Diamonds Nanocomposite for Magnetic Assisted Chemo-Photothermal Therapy

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