Functionalized graphene oxide NPs as a nanocarrier for drug delivery system in quercetin/ lurbinectedin as dual sensitive therapeutics for A549 lung cancer treatment

Liao, Ruomin; Zhang, Yi; Mao, Wenwei

doi:10.1016/j.heliyon.2024.e31212

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e31212

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Functionalized graphene oxide NPs as a nanocarrier for drug delivery system in quercetin/ lurbinectedin as dual sensitive therapeutics for A549 lung cancer treatment

Ruomin Liao,

Yi Zhang,

Wenwei Mao

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2024

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Graphene-Oxide Peptide-Containing Materials for Biomedical Applications

Gostaviceanu,

Gavrilaş,

Copolovici

et al. 2024

IJMS

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This review explores the application of graphene-based materials (GBMs) in biomedicine, focusing on graphene oxide (GO) and its interactions with peptides and proteins. GO, a versatile nanomaterial with oxygen-containing functional groups, holds significant potential for biomedical applications but faces challenges related to toxicity and environmental impact. Peptides and proteins can be functionalized on GO surfaces through various methods, including non-covalent interactions such as π–π stacking, electrostatic forces, hydrophobic interactions, hydrogen bonding, and van der Waals forces, as well as covalent bonding through reactions involving amide bond formation, esterification, thiol chemistry, and click chemistry. These approaches enhance GO’s functionality in several key areas: biosensing for sensitive biomarker detection, theranostic imaging that integrates diagnostics and therapy for real-time treatment monitoring, and targeted cancer therapy where GO can deliver drugs directly to tumor sites while being tracked by imaging techniques like MRI and photoacoustic imaging. Additionally, GO-based scaffolds are advancing tissue engineering and aiding tissues’ bone, muscle, and nerve tissue regeneration, while their antimicrobial properties are improving infection-resistant medical devices. Despite its potential, addressing challenges related to stability and scalability is essential to fully harness the benefits of GBMs in healthcare.

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Graphene-Oxide Peptide-Containing Materials for Biomedical Applications

Gostaviceanu,

Gavrilaş,

Copolovici

et al. 2024

IJMS

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show abstract

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Functionalized graphene oxide NPs as a nanocarrier for drug delivery system in quercetin/ lurbinectedin as dual sensitive therapeutics for A549 lung cancer treatment

Cited by 1 publication

References 44 publications

Graphene-Oxide Peptide-Containing Materials for Biomedical Applications

Graphene-Oxide Peptide-Containing Materials for Biomedical Applications

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