Functionalized Multiarmed Polycaprolactones as Biocompatible Tissue Adhesives

Abstract

Existing tissue adhesives have a trade-off between adhesive strength and biocompatibility. Here, we report a series of biocompatible multiarmed polycaprolactones (PCL) as tissue adhesives that can be released from a hot glue gun and the length of each arm was kept at ∼2–3 kg mol–1 in all the polymers. The adhesion properties were dependent on the number of functionalized (N-hydroxysuccinimide ester (NHS), aldehyde (CHO), and isocyanate (NCO)) arms of the multiarmed polymers. The more arms, the higher the adhesion strength. For example, the adhesion strength in binding cut rat skin increased from 2.3 N cm–2 for 2PCL-NHS to 11.2 N cm–2 for 8-PCL-NHS. CHO- and NCO-modified 8PCL also had suitable adhesive properties. All the multiarmed polymers had minimal cytotoxicity in vitro and good biocompatibility in vivo, suggesting their potential as promising alternative surgical adhesives.

A novel bioactive polyurethane with controlled degradation and L-Arg release used as strong adhesive tissue patch for hemostasis and promoting wound healing

“…Previous reports on tissue wound adhesive tend to focus on adhesion, and degradability of the material [ 5 ], while the enhancement of skin healing process and the regeneration of BVs are less investigated, and few wound adhesives with multifunction of adhesion to hemostasis, BVs growth promotion and degradation safety are reported [ [6] , [7] , [8] ]. Hence, it is of clinical significance to construct versatile wound adhesive for addressing these problems [ [9] , [10] , [11] ].…”

“…The safety of biodegradation enables the material to have excellent degradation properties while avoiding the accumulation of tissue acid and thus inflammation. Furthermore, related studies have shown that it exerts the adhesion through strong hydrogen bonding among molecular, instead of current tissue adhesives, which functionalized using isocyanate (NCO) [ 23 ], aldehyde (CHO) [ 24 ] or NHS-activated ester [ 10 , 25 , 26 ], achieving adhesion through chemical bonding, more inclined to release low-molecular compounds, bring about unpredictable harm to the body.…”

Enhancing Tissue Adhesion and Osteoblastic Differentiation of MC3T3‐E1 Cells on Poly(aryl ether ketone) by Chemically Anchored Hydroxyapatite Nanocomposite Hydrogel Coating

“…It could be observed from Figure 7e,f that the lap shear adhesion strength gradually increased to around 300 KPa with the increase of NHS ester content following the order of GN 3 AH 1 > GN 2 AH 1 > GN 1 AH 1 > GAH 1 . [ 54 ] And the strength of GAH 1 was significantly less than that of GN 1 A, which proved that the NHS not only had adhesion ability but also was superior to the effect produced by nano‐HA. The amide bond formed by the reaction of NHS with the amino groups on the tissue surface was stronger than the unstable physical interaction caused by PAA [ 38,55 ] and nano‐HA, which could explain the above phenomenon.…”

A Novel In Vitro Method to Assess the Microbial Barrier Function of Tissue Adhesives Using Bioluminescence Imaging Technique

“…For decades, sutures, metallic ware, and staples have been used as the main method to achieve wound closure or internal implant fixation in surgical setups [ 1 , 2 ]. However, these methods can cause a deficiency of tissue integration, significant mismatch between tissue and fixation, leakage, and additional trauma leading to surgical site infection (SSI) by microorganisms [ 3 , 4 ]. Tissue glue as a physical barrier device against microorganism penetration can provide a fast and noninvasive option with easier application method compare to the traditional invasive techniques [ 5 ].…”