Functionalized nanographene sheets with high antiviral activity through synergistic electrostatic and hydrophobic interactions

Donskyi, Ievgen S.; Azab, Walid; Cuellar-Camacho, José Luis; Guday, Guy; Lippitz, Andreas; Unger, Wolfgang; Osterrieder, Nikolaus; Adeli, Mohsen; Haag, Rainer

doi:10.1039/c9nr05273a

Cited by 92 publications

(80 citation statements)

References 45 publications

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“…Graphene‐based nanomaterials prevent viral infection by direct virion interaction caused by electrostatic and hydrophobic interactions (Donskyi et al., 2019; Ye et al., 2015). Studies have shown the sheet‐like structure of these nanomaterials to destroy the viral envelope (Sametband, Kalt, Gedanken, & Sarid, 2014; Ye et al., 2015).…”

Section: Resultsmentioning

confidence: 99%

Viral filtration using carbon‐based materials

et al. 2020

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Viral infections alone are a significant cause of morbidity and mortality worldwide and have a detrimental impact on global healthcare and socio‐economic development. The discovery of novel antiviral treatments has gained tremendous attention and support with the rising number of viral outbreaks. In this work, carbonaceous materials, including graphene nanoplatelets and graphene oxide nanosheets, were investigated for antiviral properties. The materials were characterized using scanning electron microscopy and transmission electron microscopy. Analysis showed the materials to be two‐dimensional with lateral dimensions ranging between 1 and 4 µm for graphene oxide and 110 ± 0.11 nm for graphene nanoplatelets. Antiviral properties were assessed against a DNA virus model microorganism at concentrations of 0.5, 1.0 and 2.0 wt/v%. Both carbonaceous nanomaterials exhibited potent antiviral properties and gave rise to a viral reduction of 100% across all concentrations tested. Graphene oxide nanosheets were then incorporated into polymeric fibres, and their antiviral behaviour was examined after 3 and 24 hr. A viral reduction of 39% was observed after 24 hr of exposure. The research presented here showcases, for the first time, the antiviral potential of several carbonaceous nanomaterials, also included in a carrier polymer. These outcomes can be translated and implemented in many fields and devices to prevent viral spread and infection.

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Section: Resultsmentioning

confidence: 99%

Viral filtration using carbon‐based materials

et al. 2020

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“…In recent years, due to their unique properties and biocompatibility, especially non‐toxic metabolism, carbon nanomaterials including CDs,9,10,14,77 nanographene sheets,43,78 graphene quantum dots,13 have been extensively investigated and proved to have outstanding antiviral effects. They are prepared by polyglycerol, 4‐aminophenylboronic acid hydrochloride, benzoxazine, PEG‐diamine, 3‐ethoxypropylamine, curcumin, and other raw materials.…”

Section: Discussionmentioning

confidence: 99%

Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

Tong

Zhou

et al. 2020

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With the gradual usage of carbon dots (CDs) in the area of antiviral research, attempts have been stepped up to develop new antiviral CDs with high biocompatibility and antiviral effects. In this study, a kind of highly biocompatible CDs (Gly‐CDs) is synthesized from active ingredient (glycyrrhizic acid) of Chinese herbal medicine by a hydrothermal method. Using the porcine reproductive and respiratory syndrome virus (PRRSV) as a model, it is found that the Gly‐CDs inhibit PRRSV proliferation by up to 5 orders of viral titers. Detailed investigations reveal that Gly‐CDs can inhibit PRRSV invasion and replication, stimulate antiviral innate immune responses, and inhibit the accumulation of intracellular reactive oxygen species (ROS) caused by PRRSV infection. Proteomics analysis demonstrates that Gly‐CDs can stimulate cells to regulate the expression of some host restriction factors, including DDX53 and NOS3, which are directly related to PRRSV proliferation. Moreover, it is found that Gly‐CDs also remarkably suppress the propagation of other viruses, such as pseudorabies virus (PRV) and porcine epidemic diarrhea virus (PEDV), suggesting the broad antiviral activity of Gly‐CDs. The integrated results demonstrate that Gly‐CDs possess extraordinary antiviral activity with multisite inhibition mechanisms, providing a promising candidate for alternative therapy for PRRSV infection.

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“…20 Other examples that mimic the extracellular cell matrix have been reported, which include GO functionalization with polyglycerol sulfate, 32 b-cyclodextrin 33 and polyglycerol sulphate in combination with alkyl chains. 34 A main issue regarding the functionalization of GO is controlling the density and distribution of the groups attached to the surface. Gholami et al 35 developed a one-pot [2 + 1] nitrene cycloaddition reaction to functionalize graphene by 2-azido-4,6-dichloro-1,3,5-triazine ( Fig.…”

Section: Mimicking the Cell Surfacementioning

confidence: 99%

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2020

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Functionalized nanographene sheets with high antiviral activity through synergistic electrostatic and hydrophobic interactions

Abstract: Schematic representation of synergistic action of electrostatic interactions of polyglycerol sulfate and conjugated aliphatic chains to the surface of nG-PGS.

Cited by 92 publications

References 45 publications

Viral filtration using carbon‐based materials

Viral filtration using carbon‐based materials

Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

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