Functionalized nanozyme with drug loading for enhanced tumour combination treatment of catalytic therapy and chemotherapy

Abstract

Nanozyme-based tumour catalytic therapy has attracted widespread attention in recent years, but the therapeutic efficacy is limited due to the trapping of hydroxyl radical (·OH) by endogenous glutathione (GSH) in...

Nanozymes with biomimetically designed properties for cancer treatment

“…In addition to the biomimetic structures, MOFs also have some inherent characteristics that can aid the improvement of the catalytic performance, such as high specific surface area, tunable pore size, abundant and uniformly dispersed active sites, and multiple interconnected channels. 44 MOFs such as those based on iron, 45 copper, 46 and zirconium 47 have been developed as biomimetic nano-enzymes and the catalytic ability can be enhanced by doping various metal elements or incorporating multi-element alloy nanoparticles as active sites. 48 We can either mimic the MOF system for better catalytic performance or take full advantage of its robust restriction framework as a carrier for biomimetic enzymes.…”

“…This comprehensive strategy not only amplifies DOX therapeutic impact but also markedly diminishes the risk of cardiac damage often associated with the drug. Song et al 47 constructed Zr/Ce-MOFs/DOX/MnO 2 , which serves as a new type of nanosome for combined chemotherapy and catalytic treatment (Fig. 13C).…”

“…MOFs such as those based on iron, 45 copper, 46 and zirconium 47 have been developed as biomimetic nano-enzymes and the catalytic ability can be enhanced by doping various metal elements or incorporating multi-element alloy nanoparticles as active sites. 48 We can either mimic the MOF system for better catalytic performance or take full advantage of its robust restriction framework as a carrier for biomimetic enzymes.…”