Functionalized-radiolabeled hydroxyapatite/tenorite nanoparticles as theranostic agents for osteosarcoma

Cipreste, Marcelo Fernandes; Rezende, Michele Rocha de; Hneda, Marlon Luiz; Peres, Anderson M.; Cotta, Alexandre Alberto Chaves; Teixeira, Verônica C.; Macedo, W. A. A.; Sousa, Edésia Martins Barros de

doi:10.1016/j.ceramint.2018.06.248

Cited by 16 publications

(17 citation statements)

References 41 publications

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“…Typical bands of mesoporous silica are widely reported and can be easily identified at 460 and 810 cm −1 , relative to the symmetric stretching of Si-O-Si bonds, between 1150 and 1100 cm −1 , related to the asymmetric stretching of Si-O-Si bonds; 3100 and 3700 cm −1 , attributed to the stretching modes of the O-H bonds of the silanol (Si-OH) groups and 960 and 1640 cm −1 attributed to the silanol (Si-OH) groups in the structure of the material. 36 The absorption around 961 cm −1 is associated with the presence of PO 4 group as described by Cipreste et al 36 This absorption band can overlap the band around 960 cm −1 corresponding to the silanol (Si-OH) groups present in the structure of the material. 36 The absorption around 961 cm −1 is associated with the presence of PO 4 group as described by Cipreste et al 36 This absorption band can overlap the band around 960 cm −1 corresponding to the silanol (Si-OH) groups present in the structure of the material.…”

Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 87%

“…17 The presence of the calcium phosphate can be verified by the bands at 560-640 cm −1 corresponding to the phosphate group (PO 4 ). 36 The absorption around 961 cm −1 is associated with the presence of PO 4 group as described by Cipreste et al 36 This absorption band can overlap the band around 960 cm −1 corresponding to the silanol (Si-OH) groups present in the structure of the material. 37 The peaks around 2950 and 2850 cm −1 are attributed to the symmetrical and asymmetrical elongation of the -CH 2 and CH 3 groups, which arose due to the incorporation of the polymer phases.…”

Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 87%

“…Similar work described in the literature also showed the presence of HA phase, confirmed due to the appearance of characteristic patterns in the Bragg angles. 36 The work developed by Azami et al confirmed the presence of calcium fluoride and apatite patterns. 39…”

Section: X-ray Diffractionmentioning

confidence: 93%

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Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

Apostolos¹,

Andrade²,

Silva³

et al. 2019

Int J Applied Ceramic Tech

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In this study, we report the production of a mesoporous silica/hydroxyapatite‐based nanocomposite containing copper (Cu) functionalized with methacrylic acid (MAA), a pH‐sensitive polymer. The functionalization of the nanoparticles surface was performed using the microwave method in order to anchor the cross‐linking tetraethylene glycol dimethacrylate (TEGDMA), onto the nanoparticles surface followed by MAA polymerization. The materials were characterized by XRD, XRF spectroscopy, scanning and transmission electron microscopy, Fourier transform infrared spectroscopy, thermal analysis, zeta potential, and elemental analysis. Studies of the incorporation and release of the antitumor methotrexate drug were performed in order to evaluate the potential use of these drug carrier systems in cancer therapy. Moreover, the in vitro cytotoxicity of the samples in fibroblast and SAOS‐2 cells was investigated, and the activity of the adipose‐derived stem cell alkaline phosphatase on nanocomposites was studied by in vitro assays. The results indicate that the Cu‐containing nanocomposites can be easily produced and that these compositions have beneficial effects in stem cells, maintaining cell viability, and allowing alkaline phosphatase expression. In conclusion, data from this work show that the nanocomposites obtained have adequate characteristic to be used as drug delivery platform. Furthermore, the biomaterial is a promising structure for treatment of bone tumor.

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Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 87%

Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 87%

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Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

Apostolos¹,

Andrade²,

Silva³

et al. 2019

Int J Applied Ceramic Tech

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“…Cipreste et al 56 showed that 32 P/ 64 Cu radiolabeled HA nanorods can reduce SAOS-2 cancer cells viability. In their study, 89 Sr radioisotope with concentrations above 148 kBq/mL can inhibit the proliferation of MCF-7 cancer cells.…”

Section: Cytotoxic Effect Of Nanoparticles On Saos and Fibroblasts mentioning

confidence: 99%

“…In their study, 89 Sr radioisotope with concentrations above 148 kBq/mL can inhibit the proliferation of MCF-7 cancer cells. Cipreste et al 56 showed that 32 P/ 64 Cu radiolabeled HA nanorods can reduce SAOS-2 cancer cells viability. These works suggest that strontium-89 radiolabeled HA nanoparticles are promisor agents to act in the…”

Section: Saos and Fibroblasts Cellsmentioning

confidence: 99%

⁸⁹Sr‐doped hydroxyapatite nanoparticles as a potential therapeutic agent for bone tumors

Rezende

Andrade

Cipreste

et al. 2019

Int J Applied Ceramic Tech

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Hydroxyapatite (HA) nanoparticles have been studied due to their high biocompatibility, similarity with bone tissue, and their capacity for bone regeneration since these nanoparticles can easily adhere on osteosarcoma and osteoblast cells, promoting osteoblast growth and osteosarcoma cell uptake. These materials may still accumulate spontaneously and selectively in regions of bone tumors through the enhanced permeability and retention effect. HA also allows the incorporation of strontium in your network. Strontium as a biochemical analog of calcium can maintain the osteogenesis characteristics of HA allowing the production of the radioactive isotopes strontium‐89 and phosphorus‐32 through neutron irradiation. These radioisotopes are beta emitters that enable the treatment of bone tumors, while the affected region is regenerated. In this work, we investigated the synthesis of strontium‐doped HA nanorods through the hydrothermal coprecipitation method as a potential therapeutic agent for bone tumors. All materials were successfully obtained and demonstrated high cell viability, maintaining the osteogenic capacity, making these materials promising agents for the specific treatment of bone tumors. The results indicate that the Sr provides an increase in therapeutic potential due to its beta emission.

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Theranostics Nanoformulations: Merging Diagnostics and Nanotherapeutics

Khot

Rawal

Patel

2020

Nanoformulations in Human Health

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Functionalized-radiolabeled hydroxyapatite/tenorite nanoparticles as theranostic agents for osteosarcoma

Cited by 16 publications

References 41 publications

Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

⁸⁹Sr‐doped hydroxyapatite nanoparticles as a potential therapeutic agent for bone tumors

Theranostics Nanoformulations: Merging Diagnostics and Nanotherapeutics

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Functionalized-radiolabeled hydroxyapatite/tenorite nanoparticles as theranostic agents for osteosarcoma

Cited by 16 publications

References 41 publications

Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

89Sr‐doped hydroxyapatite nanoparticles as a potential therapeutic agent for bone tumors

Theranostics Nanoformulations: Merging Diagnostics and Nanotherapeutics

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Product

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⁸⁹Sr‐doped hydroxyapatite nanoparticles as a potential therapeutic agent for bone tumors