Functionalized silicon dioxide self-referenced plasmonic chip as point-of-care biosensor for stroke biomarkers NT-proBNP and S100β

Harpaz, Dorin; Koh, Brescia; Seet, Raymond C.S.; Abdulhalim, Ibrahim; Tok, Alfred Iing Yoong

doi:10.1016/j.talanta.2020.120792

Cited by 36 publications

(14 citation statements)

References 60 publications

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“…Gupta & Sharma, 2005), long range SPR (Isaacs & Abdulhalim, 2015), guided wave SPR (Lahav, Auslender, & Abdulhalim, 2008;C. Lin & Chen, 2019), or self-referenced plasmon waveguide SPR (Harpaz, Koh, Seet, Abdulhalim, & Tok, 2020). As an example, Isaacs and collaborators developed a self-referenced Plasmon Waveguide Resonance (PWR) sensor that consisted of an insulator-metal-insulator chip to achieve resonance using both TE and TM polarizations, resulting in a narrower resonance of classical SPR based sensor (Isaacs, Harté, D Alves, & Abdulhalim, 2019).…”

Section: Optical and Plasmonics Biosensorsmentioning

confidence: 99%

Plasmonic biosensors for food control

Balbinot

Srivastav

Vidić

et al. 2021

Trends in Food Science & Technology

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Background: Food safety is becoming increasingly important because food industry must provide quality products to minimize the health risks. Traditional methods to assure food safety, such as plate count and polymerase chain reaction are accurate and robust but can hardly satisfy the needs of the food industry because they are costly and time consuming. Therefore, optical biosensors that can analyze food in a low-cost, facile, fast, sensitive, and selective manner started to emerge. Scope and approach: This review presents plasmonic biosensors including surface plasmon resonance (SPR), localized SPR (LSPR), fiber optic SPR (FO-SPR), surface enhanced Raman scattering (SERS), surface-enhanced fluorescence (SEF), and total internal reflection (TIR) based sensors and their applications in food pathogens monitoring. Moreover, the strengths and weaknesses of plasmonic biosensors implementation in food control are showcased. Key findings and conclusions: Plasmonic biosensors could simplify procedure and radically reduce time, price and consummation of reactants, compared to traditional microbiological methods. Optical biosensors, in particular SPR, have been developed for detection of different foodborne pathogens. In parallel, analytical improvements have been achieved by coupling different techniques (fiber optics, Raman, fluorescence, luminescence) to plasmonic sensors in order to reduce the limits of detection and to improve sensitivity. The future improvements include the miniaturization of instruments to handheld devices and simplification of analysis to enable direct target detection in food matrices. Plasmonic technology can certainly have long lasting impact because the need for a simple and rapid food assay is pressing and guarantees the future development in this field.

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Section: Optical and Plasmonics Biosensorsmentioning

confidence: 99%

Plasmonic biosensors for food control

Balbinot

Srivastav

Vidić

et al. 2021

Trends in Food Science & Technology

Self Cite

123

View full text Add to dashboard Cite

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“…Several designs have been proposed to promote SPR excitation, each resorting to different coupling devices such as prisms [27,28], waveguides [29][30][31][32] and gratings [33,34]. Among the existing methods, the Kretschmann−Raether configuration remains the most popular in commercial systems nowadays.…”

Section: Surface Plasmon Resonance and Localized Surface Plasmon Resonancementioning

confidence: 99%

“…Furthermore, the resonant frequency is highly dependent on the dielectric environment, distance between particles and intrinsic properties of the metal NPs, namely composition, size, shape, geometry and aspect ratio [ 17 , 40 ]. Therefore, tuning these factors can optimize the detection performance towards a specific target [ 27 ]. Some benefits of LSPR include enhanced light intensity at the resonant wavelength and high spatial resolution, and the use of NPs offers a larger surface contact area than continuous films, allowing more analytes to bind to the metals [ 41 , 42 ].…”

Section: Theoretical Background On Optical Fiber Biosensing Working Principlesmentioning

confidence: 99%

Immunosensing Based on Optical Fiber Technology: Recent Advances

et al. 2021

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The evolution of optical fiber technology has revolutionized a variety of fields, from optical transmission to environmental monitoring and biomedicine, given their unique properties and versatility. For biosensing purposes, the light guided in the fiber core is exposed to the surrounding media where the analytes of interest are detected by different techniques, according to the optical fiber configuration and biofunctionalization strategy employed. These configurations differ in manufacturing complexity, cost and overall performance. The biofunctionalization strategies can be carried out directly on bare fibers or on coated fibers. The former relies on interactions between the evanescent wave (EW) of the fiber and the analyte of interest, whereas the latter can comprise plasmonic methods such as surface plasmon resonance (SPR) and localized SPR (LSPR), both originating from the interaction between light and metal surface electrons. This review presents the basics of optical fiber immunosensors for a broad audience as well as the more recent research trends on the topic. Several optical fiber configurations used for biosensing applications are highlighted, namely uncladded, U-shape, D-shape, tapered, end-face reflected, fiber gratings and special optical fibers, alongside practical application examples. Furthermore, EW, SPR, LSPR and biofunctionalization strategies, as well as the most recent advances and applications of immunosensors, are also covered. Finally, the main challenges and an outlook over the future direction of the field is presented.

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“…The sensing of b-type natriuretic peptides for clinically useful diagnostic assays demonstrates analytical problems, mainly with circulating NT-proBNP [ 161 ], assay specificity, and analyte stability [ 162 , 163 , 164 , 165 ]. Several previous studies examined the development of NT-proBNP immunoassays [ 166 , 167 , 168 ]. There is no consensus on the exact circulating peptides that are derived from proBNP [ 80 , 169 , 170 ].…”

Section: Detection Of B-type Natriuretic Peptidesmentioning

confidence: 99%

B-Type Natriuretic Peptide as a Significant Brain Biomarker for Stroke Triaging Using a Bedside Point-of-Care Monitoring Biosensor

et al. 2020

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Stroke is a widespread condition that causes 7 million deaths globally. Survivors suffer from a range of disabilities that affect their everyday life. It is a complex condition and there is a need to monitor the different signals that are associated with it. Stroke patients need to be rapidly diagnosed in the emergency department in order to allow the admission of the time-limited treatment of tissue plasminogen activator (tPA). Stroke diagnostics show the use of sophisticated technologies; however, they still contain limitations. The hidden information and technological advancements behind the utilization of biomarkers for stroke triaging are significant. Stroke biomarkers can revolutionize the way stroke patients are diagnosed, monitored, and how they recover. Different biomarkers indicate different cascades and exhibit unique expression patterns which are connected to certain pathologies in the human body. Over the past decades, B-type natriuretic peptide (BNP) and its derivative N-terminal fragment (NT-proBNP) have been increasingly investigated and highlighted as significant cardiovascular biomarkers. This work reviews the recent studies that have reported on the usefulness of BNP and NT-proBNP for stroke triaging. Their classification association is also presented, with increased mortality in stroke, correlation with cardioembolic stroke, and an indication of a second stroke recurrence. Moreover, recent scientific efforts conducted for the technological advancement of a bedside point-of-care (POC) device for BNP and NT-proBNP measurements are discussed. The conclusions presented in this review may hopefully assist in the major efforts that are currently being conducted in order to improve the care of stroke patients.

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Functionalized silicon dioxide self-referenced plasmonic chip as point-of-care biosensor for stroke biomarkers NT-proBNP and S100β

Cited by 36 publications

References 60 publications

Plasmonic biosensors for food control

Plasmonic biosensors for food control

Immunosensing Based on Optical Fiber Technology: Recent Advances

B-Type Natriuretic Peptide as a Significant Brain Biomarker for Stroke Triaging Using a Bedside Point-of-Care Monitoring Biosensor

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