Functionalized silver nanoparticles depress aerobic metabolism in the absence of overt toxicity in brackish water killifish, Fundulus heteroclitus

Campbell, Lynn; Gormley, Patrick T.; Bennett, Craig; Murimboh, John; MacCormack, Tyson J.

doi:10.1016/j.aquatox.2019.105221

Cited by 10 publications

(6 citation statements)

References 72 publications

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“…The high exposure doses required to elicit hepatocyte responses suggest that neither nB 2 O 3 nor BA are particularly toxic, at least for this cell type. Some ENM formulations specifically alterṀO 2min orṀO 2max in fish (Black et al, 2017;Campbell et al, 2019), while in other species, subtle effects on both contribute to reductions in aerobic scope (Callaghan et al, 2016). The aerobic metabolic depression induced by nB 2 O 3 in isolated hepatocytes was not replicated in whole animal exposures with any species tested.…”

Section: Discussionmentioning

confidence: 91%

“…In F. diaphanus,ṀO 2max represented the highestṀO 2 value recorded following the exhaustive chase protocol and aerobic scope was calculated as the difference betweenṀO 2min andṀO 2max . Variability inṀO 2 recordings from undisturbed fish can be used as a proxy for spontaneous aerobic activity in fish (Campbell et al, 2019). Frequency distributions oḟ MO 2 recordings from the final 5 h of each respirometry trial were generated using Prism 7 (GraphPad Software, Inc., CA, United States).…”

Section: Data Analysis and Statisticsmentioning

confidence: 99%

“…Plots illustrate the number ofṀO 2 recordings from each species that fell within each 30 mg kg −1 h −1 bin. The frequency distributions thus provide a qualitative means to visualize variability in the aerobic activity of the animals over the selected recording period (Campbell et al, 2019). In all trials,ṀO 2 returned to baseline levels within the first 4 h after insertion into the respirometry system and fish were not disturbed during the period over which the frequency distribution analysis was examined.…”

Section: Data Analysis and Statisticsmentioning

confidence: 99%

“…Contaminant-induced reductions in aerobic scope can have negative consequences on fish populations (Johansen and Esbaugh, 2017). ENM exposure influences whole animalṀO 2 in fish under certain conditions (Callaghan et al, 2016), sometimes in the absence of clear biochemical indicators of toxicity (Black et al, 2017;Campbell et al, 2019). Understanding how nB 2 O 3 exposure affects aerobic metabolism in a variety of fish species will contribute valuable information on its overall environmental safety.…”

Section: Introductionmentioning

confidence: 99%

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Boron Oxide Nanoparticles Exhibit Minor, Species-Specific Acute Toxicity to North-Temperate and Amazonian Freshwater Fishes

MacCormack

Gormley

Khuong

et al. 2021

Front. Bioeng. Biotechnol.

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Boron oxide nanoparticles (nB2O3) are manufactured for structural, propellant, and clinical applications and also form spontaneously through the degradation of bulk boron compounds. Bulk boron is not toxic to vertebrates but the distinctive properties of its nanostructured equivalent may alter its biocompatibility. Few studies have addressed this possibility, thus our goal was to gain an initial understanding of the potential acute toxicity of nB2O3 to freshwater fish and we used a variety of model systems to achieve this. Bioactivity was investigated in rainbow trout (Oncorhynchus mykiss) hepatocytes and at the whole animal level in three other North and South American fish species using indicators of aerobic metabolism, behavior, oxidative stress, neurotoxicity, and ionoregulation. nB2O3 reduced O. mykiss hepatocyte oxygen consumption (ṀO2) by 35% at high doses but whole animal ṀO2 was not affected in any species. Spontaneous activity was assessed using ṀO2 frequency distribution plots from live fish. nB2O3 increased the frequency of high ṀO2 events in the Amazonian fish Paracheirodon axelrodi, suggesting exposure enhanced spontaneous aerobic activity. ṀO2 frequency distributions were not affected in the other species examined. Liver lactate accumulation and significant changes in cardiac acetylcholinesterase and gill Na+/K+-ATPase activity were noted in the north-temperate Fundulus diaphanus exposed to nB2O3, but not in the Amazonian Apistogramma agassizii or P. axelrodi. nB2O3 did not induce oxidative stress in any of the species studied. Overall, nB2O3 exhibited modest, species-specific bioactivity but only at doses exceeding predicted environmental relevance. Chronic, low dose exposure studies are required for confirmation, but our data suggest that, like bulk boron, nB2O3 is relatively non-toxic to aquatic vertebrates and thus represents a promising formulation for further development.

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Section: Discussionmentioning

confidence: 91%

Section: Data Analysis and Statisticsmentioning

confidence: 99%

Section: Data Analysis and Statisticsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Boron Oxide Nanoparticles Exhibit Minor, Species-Specific Acute Toxicity to North-Temperate and Amazonian Freshwater Fishes

MacCormack

Gormley

Khuong

et al. 2021

Front. Bioeng. Biotechnol.

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“…Upon exposure to 5 nm PVP-AgNPs (80 μg L −1 for 48 h), adult killifish, Fundulus heteroclitus , showed a significant depression of oxygen consumption (ṀO 2 min and ṀO 2 max) compared to control fish, but neither aerobic scope nor biochemical indicators of toxicity were affected as well as gill epithelium ( Campbell et al, 2019 ). Furthermore, gill NKA activity, although sensitive to Ag ions, did not affect specimens exposed to PVP-AgNPs suggesting that dissolution, even occurring, is not making Ag bioavailable to fish gills.…”

Section: Aquatic Ecotoxicity Of Silver Nanoparticlesmentioning

confidence: 98%

Building the Bridge From Aquatic Nanotoxicology to Safety by Design Silver Nanoparticles

Corsi

Desimone

Cazenave

2022

Front. Bioeng. Biotechnol.

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Nanotechnologies have rapidly grown, and they are considered the new industrial revolution. However, the augmented production and wide applications of engineered nanomaterials (ENMs) and nanoparticles (NPs) inevitably lead to environmental exposure with consequences on human and environmental health. Engineered nanomaterial and nanoparticle (ENM/P) effects on humans and the environment are complex and largely depend on the interplay between their peculiar properties such as size, shape, coating, surface charge, and degree of agglomeration or aggregation and those of the receiving media/body. These rebounds on ENM/P safety and newly developed concepts such as the safety by design are gaining importance in the field of sustainable nanotechnologies. This article aims to review the critical characteristics of the ENM/Ps that need to be addressed in the safe by design process to develop ENM/Ps with the ablility to reduce/minimize any potential toxicological risks for living beings associated with their exposure. Specifically, we focused on silver nanoparticles (AgNPs) due to an increasing number of nanoproducts containing AgNPs, as well as an increasing knowledge about these nanomaterials (NMs) and their effects. We review the ecotoxicological effects documented on freshwater and marine species that demonstrate the importance of the relationship between the ENM/P design and their biological outcomes in terms of environmental safety.

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Silver nanoparticle–induced ecotoxicity

Ale,

Andrade,

Desimone

et al. 2024

Silver Nanoparticles for Drug Delivery

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Functionalized silver nanoparticles depress aerobic metabolism in the absence of overt toxicity in brackish water killifish, Fundulus heteroclitus

Cited by 10 publications

References 72 publications

Boron Oxide Nanoparticles Exhibit Minor, Species-Specific Acute Toxicity to North-Temperate and Amazonian Freshwater Fishes

Boron Oxide Nanoparticles Exhibit Minor, Species-Specific Acute Toxicity to North-Temperate and Amazonian Freshwater Fishes

Building the Bridge From Aquatic Nanotoxicology to Safety by Design Silver Nanoparticles

Silver nanoparticle–induced ecotoxicity

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