Functionalizing Liposomes with anti-CD44 Aptamer for Selective Targeting of Cancer Cells

Alshaer, Walhan; Hillaireau, Hervé; Vergnaud-Gauduchon, Juliette; Ismail, Said I.; Fattal, Elias

doi:10.1021/bc5004313

Cited by 161 publications

(96 citation statements)

References 34 publications

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“…Although there is promising data emerging from the preclinical setting in the targeting of CD44, CD133, EpCAM, and CD90 (discussed below), the largest hurdle will be demonstrating safety and efficacy in vivo. Methodologies targeting CD44 include anti-CD44 monoclonal antibodies [106] and anti-CD44 antibody or aptamer-labelled liposomes [107,108]. The CD44 ligand, hyaluronic acid, has also been used to label nanocarriers and conjugates, with demonstrated efficacy in reducing CD44?…”

Section: Targeting Cancer Stem Cell Surface Markersmentioning

confidence: 99%

Gastric cancer stem cells: evidence, potential markers, and clinical implications

et al. 2015

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Gastric cancer is a significant global health problem. It is the fifth most common cancer and third leading cause of cancer-related death worldwide (Torre et al. in CA Cancer J Clin 65(2):87-108, 2015). Despite advances in treatment, overall prognosis remains poor, due to tumour relapse and metastasis. There is an urgent need for novel therapeutic approaches to improve clinical outcomes in gastric cancer. The cancer stem cell (CSC) model has been proposed to explain the high rate of relapse and subsequent resistance of cancer to current systemic treatments (Vermeulen et al. in Lancet Oncol 13(2):e83-e89, 2012). CSCs have been identified in many solid malignancies, including gastric cancer, and have significant clinical implications, as targeting the CSC population may be essential in preventing the recurrence and spread of a tumour (Dewi et al. in J Gastroenterol 46(10):1145-1157, 2011). This review seeks to summarise the current evidence for CSC in gastric cancer, with an emphasis on candidate CSC markers, clinical implications, and potential therapeutic approaches.

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Section: Targeting Cancer Stem Cell Surface Markersmentioning

confidence: 99%

Gastric cancer stem cells: evidence, potential markers, and clinical implications

et al. 2015

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“…As we know, liposome is the most popular vector in current drug delivery due to its mature and simple preparation, high drug loadings, prolonged blood circulation half-lives, tumortargeting ability, and high in vivo biosafety. [35][36][37] Recently, several formulations of liposome-based DDSs have been approved by Food and Drug Administration and European Medicines Agency for the treatment of cancer. 38 Thus, in this study, DPPC, DSPE-PEG (common phospholipid material), and DOX (a water-soluble antitumor drug) were used to build a DOX-loaded liposome via film dispersion method.…”

Section: Discussionmentioning

confidence: 99%

A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance

Shi¹,

Su²,

Liu³

et al. 2017

IJN

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Recently, stimuli-responsive drug delivery systems (DDSs) with high spatial/temporal resolution bring many benefits to cancer treatment. However, cancer cells always develop ways to resist and evade treatment, ultimately limit the treatment efficacy of the DDSs. Here, we introduce photo-activated nanoliposomes (PNLs) that impart light-induced cytotoxicity and reversal of drug resistance in synchrony with a photoinitiated and rapid release of antitumor drug. The PNLs consist of a nanoliposome doped with a photosensitizer (hematoporphyrin monomethyl ether [HMME]) in the lipid bilayer and an antitumor drug doxorubicin (DOX) encapsulated inside. PNLs have several distinctive capabilities: 1) carrying high loadings of DOX and HMME and releasing the payloads in a photo-cleavage manner with high spatial/temporal resolution at the site of actions via photocatalysis; 2) reducing drug efflux in MCF-7/multidrug resistance cells via decreasing the level of P-glycoprotein induced by photodynamic therapy (PDT); 3) accumulating in tumor site taking advantage of the enhanced permeability and retention effect; and 4) combining effective chemotherapy and PDT to exert much enhanced anticancer effect and achieving significant tumor regression in a drug-resistant tumor model with little side effects.

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“…Functionalization of DNA-Polymer (A) microcapsules; 34 and (B) Liposomes functionalized with CD44 Aptamer 35 .…”

Section: Figurementioning

confidence: 99%

“Clicking” Gene Therapeutics: A Successful Union of Chemistry and Biomedicine for New Solutions

et al. 2018

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The use of nucleic acid, DNA and RNA, based strategies to disrupt gene expression as a therapeutic is quickly emerging. Indeed, synthetic oligonucleotides represent a major component of emerging gene therapeutics. However, the efficiency and specificity of intracellular uptake for non-modified oligonucleotides is rather poor. Utilizing RNA based oligonucleotides as therapeutics is even more challenging to deliver, due to extremely fast enzymatic degradation of the RNAs. Like unmodified oligonucleotides, RNAs also get rapidly degraded in vivo and demonstrate large off-target binding events when they can reach and enter the desired target cells. One approach that holds much promise is the utilization of “click chemistry” to conjugate receptor or cell specific targeting molecules directly to the effector oligonucleotides. We discuss here the applications of the breakthrough technology of CuAAC “click-chemistry” and the immense potential in utilizing “click chemistry” in the development of new age targeted oligonucleotide therapeutics.

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Functionalizing Liposomes with anti-CD44 Aptamer for Selective Targeting of Cancer Cells

Cited by 161 publications

References 34 publications

Gastric cancer stem cells: evidence, potential markers, and clinical implications

Gastric cancer stem cells: evidence, potential markers, and clinical implications

A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance

“Clicking” Gene Therapeutics: A Successful Union of Chemistry and Biomedicine for New Solutions

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