Functionally asymmetric motor neurons coordinate locomotion of <i>Caenorhabditis elegans</i>

Tolstenkov, Oleg; Auwera, Petrus Van der; Liewald, Jana F.; Costa, Wagner Steuer; Bazhanova, Olga; Gemeinhardt, Tim M; Bergs, Amelie; Gottschalk, Alexander

doi:10.1101/244434

Cited by 1 publication

(1 citation statement)

References 97 publications

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“…The D-class GABAergic motor neurons modulate, but are not necessary for, body bending [39,40,49], arguing against them being CPGs. The perturbation of AS, another class cholinergic and excitatory motor neurons, affects both forward and backward movement; whether they harbour intrinsic oscillatory activity is unknown [50].…”

Section: Cpgs For Body Bending Reside In the C Elegans Ventral Nerve Cordmentioning

confidence: 99%

Caenorhabditis elegans excitatory ventral cord motor neurons derive rhythm for body undulation

Wen

Gao

Zhen

2018

Phil. Trans. R. Soc. B

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The intrinsic oscillatory activity of central pattern generators underlies motor rhythm. We review and discuss recent findings that address the origin of motor rhythm. These studies propose that the A- and mid-body B-class excitatory motor neurons at the ventral cord function as non-bursting intrinsic oscillators to underlie body undulation during reversal and forward movements, respectively. Proprioception entrains their intrinsic activities, allows phase-coupling between members of the same class motor neurons, and thereby facilitates directional propagation of undulations. Distinct pools of premotor interneurons project along the ventral nerve cord to innervate all members of the A- and B-class motor neurons, modulating their oscillations, as well as promoting their bi-directional coupling. The two motor sub-circuits, which consist of oscillators and descending inputs with distinct properties, form the structural base of dynamic rhythmicity and flexible partition of the forward and backward motor states. These results contribute to a continuous effort to establish a mechanistic and dynamic model of the sensorimotor system. exhibits rich sensorimotor functions despite a small neuron number. These findings implicate a circuit-level functional compression. By integrating the role of rhythm generation and proprioception into motor neurons, and the role of descending regulation of oscillators into premotor interneurons, this numerically simple nervous system can achieve a circuit infrastructure analogous to that of anatomically complex systems. has manifested itself as a compact model to search for general principles of sensorimotor behaviours.This article is part of a discussion meeting issue 'Connectome to behaviour: modelling at cellular resolution'.

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Section: Cpgs For Body Bending Reside In the C Elegans Ventral Nerve Cordmentioning

confidence: 99%

Caenorhabditis elegans excitatory ventral cord motor neurons derive rhythm for body undulation

Wen

Gao

Zhen

2018

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

show abstract

Functionally asymmetric motor neurons coordinate locomotion of Caenorhabditis elegans

Abstract: AS neurons show asymmetry in both input and output and are specialized in coordination of dorso-1 8 ventral undulation bends. 9AS neurons mediate antero-posterior propagation of the undulatory body wave during locomotion.

Cited by 1 publication

References 97 publications

Caenorhabditis elegans excitatory ventral cord motor neurons derive rhythm for body undulation

Caenorhabditis elegans excitatory ventral cord motor neurons derive rhythm for body undulation

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