Fundamental knowledge for nurses

Lu, Da Yong; Chen, Yuzheng; Lu, Da-Feng

doi:10.15406/ncoaj.2022.08.00234

NCOAJ

2022

DOI: 10.15406/ncoaj.2022.08.00234

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Fundamental knowledge for nurses

Da Yong Lu¹,

Yuzheng Chen²,

Da-Feng Lu³

Abstract: To great promotion for nursery practice is indispensable. Knowledge for different patterns of healthcare services and nursery should be widen and more helpful. The different backgrounds and personal condition of nurses may be optimized in the clinic. This editorial addresses many interesting topic about nursery disciplines in the clinic.

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An in silico investigation of Kv2.1 potassium channel: Model building and inhibitors binding sites analysis**

Wang,

Zhang,

Zhou

et al. 2023

Molecular Informatics

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<i>in silico</i> Kv2.1 is widely expressed in brain, and inhibiting Kv2.1 is a potential strategy to prevent cell death and achieve neuroprotection in ischemic stroke. Herein, an model of Kv2.1 tetramer structure was constructed by employing the AlphaFold‐Multimer deep learning method to facilitate the rational discovery of Kv2.1 inhibitors. GaMD was utilized to create an ion transporting trajectory, which was analyzed with HMM to generate multiple representative receptor conformations. The binding site of RY785 and RY796(S) und‐ er the P‐loop was defined with Fpocket program together with the competitive binding electrophysiology assay. The docking poses of the two inhibitors were predicted with the aid of the semi‐empirical quantum mechanical calculation, and the IGMH results suggested that Met375, Thr376, and Thr377 of the P‐helix and Ile405 of the S6 segment made significant contributions to the binding affinity. These results provided insights for rational molecular design to develop novel Kv2.1 inhibitors.

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An in silico investigation of Kv2.1 potassium channel: Model building and inhibitors binding sites analysis**

Wang,

Zhang,

Zhou

et al. 2023

Molecular Informatics

View full text Add to dashboard Cite

show abstract

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Fundamental knowledge for nurses

Cited by 1 publication

References 20 publications

An in silico investigation of Kv2.1 potassium channel: Model building and inhibitors binding sites analysis**

An in silico investigation of Kv2.1 potassium channel: Model building and inhibitors binding sites analysis**

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