Fungal-Derived Natural Product: Synthesis, Function, and Applications

Singh, Amit Kumar; Rana, Harvesh Kumar; Pandey, Abhay K.

doi:10.1007/978-3-030-14846-1_8

Cited by 10 publications

(11 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Filamentous fungi (also called molds or moldy fungi) are taxonomically diverse organisms from phylum Ascomycota and Zygomycota with filamentous hyphae and the ability to produce airborne spores or conidia. Improved strains of filamentous fungi are one of the most important sources for producing pharmaceutically significant secondary metabolites (SMs), such as antibiotics, statins, and immunosuppressants [1][2][3][4]. These compounds are one of the most commonly prescribed drugs worldwide [5,6].…”

Section: Introductionmentioning

confidence: 99%

Polyamines Upregulate Cephalosporin C Production and Expression of β-Lactam Biosynthetic Genes in High-Yielding Acremonium chrysogenum Strain

Zhgun

Eldarov

2021

Molecules

View full text Add to dashboard Cite

The high-yielding production of pharmaceutically significant secondary metabolites in filamentous fungi is obtained by random mutagenesis; such changes may be associated with shifts in the metabolism of polyamines. We have previously shown that, in the Acremonium chrysogenum cephalosporin C high-yielding strain (HY), the content of endogenous polyamines increased by four- to five-fold. Other studies have shown that the addition of exogenous polyamines can increase the production of target secondary metabolites in highly active fungal producers, in particular, increase the biosynthesis of β-lactams in the Penicillium chrysogenum Wis 54–1255 strain, an improved producer of penicillin G. In the current study, we demonstrate that the introduction of exogenous polyamines, such as spermidine or 1,3-diaminopropane, to A. chrysogenum wild-type (WT) and HY strains, leads to an increase in colony germination and morphological changes in a complete agar medium. The addition of 5 mM polyamines during fermentation increases the production of cephalosporin C in the A. chrysogenum HY strain by 15–20% and upregulates genes belonging to the beta-lactam biosynthetic cluster. The data obtained indicate the intersection of the metabolisms of polyamines and beta-lactams in A. chrysogenum and are important for the construction of improved producers of secondary metabolites in filamentous fungi.

show abstract

Section: Introductionmentioning

confidence: 99%

Polyamines Upregulate Cephalosporin C Production and Expression of β-Lactam Biosynthetic Genes in High-Yielding Acremonium chrysogenum Strain

Zhgun

Eldarov

2021

Molecules

View full text Add to dashboard Cite

show abstract

“…Fungal kingdom produces a variety of secondary metabolites, including all important classes like terpenes, terpenoids, alkaloids, and sugar derivatives. Today many scientists around the world is searching for a chemical method to synthesize the secondary metabolite in laboratory at higher yield for getting the most benefits [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Botryotrichum and Scopulariopsis Secondary Metabolites and Biological Activities

Elkhateeb¹,

Daba²

2022

BTBP

View full text Add to dashboard Cite

Botryotrichum and Scopulariopsis are a fungal genera that belongs to Class: Sordariomycetes. This review is to demonstrate secondary metabolites from Botryotrichum and Scopulariopsis and some of their reported biological activities. Moreover, describing the unique chemical diversity of these fungal genera involved in medical, pharmaceutical, agricultural applications. Also highlight the harmful side of these fungi if present.

show abstract

“…Thus, natural products have long been regarded as important sources in drug design, especially for drugs for cancer and infectious diseases (Brown et al, 2014;Rodrigues et al, 2016;Agarwal et al, 2020). Furthermore, almost all-important natural products, such as terpenes, alkaloids, sesquiterpenes, and sugars, can be produced by fungi (Aly et al, 2011;Singh et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Bioactivities and Structure–Activity Relationships of Fusidic Acid Derivatives: A Review

Long

Zhang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Fusidic acid (FA) is a natural tetracyclic triterpene isolated from fungi, which is clinically used for systemic and local staphylococcal infections, including methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci infections. FA and its derivatives have been shown to possess a wide range of pharmacological activities, including antibacterial, antimalarial, antituberculosis, anticancer, tumor multidrug resistance reversal, anti-inflammation, antifungal, and antiviral activity in vivo and in vitro. The semisynthesis, structural modification and biological activities of FA derivatives have been extensively studied in recent years. This review summarized the biological activities and structure–activity relationship (SAR) of FA in the last two decades. This summary can prove useful information for drug exploration of FA derivatives.

show abstract

Fungal-Derived Natural Product: Synthesis, Function, and Applications

Cited by 10 publications

References 101 publications

Polyamines Upregulate Cephalosporin C Production and Expression of β-Lactam Biosynthetic Genes in High-Yielding Acremonium chrysogenum Strain

Polyamines Upregulate Cephalosporin C Production and Expression of β-Lactam Biosynthetic Genes in High-Yielding Acremonium chrysogenum Strain

Botryotrichum and Scopulariopsis Secondary Metabolites and Biological Activities

Bioactivities and Structure–Activity Relationships of Fusidic Acid Derivatives: A Review

Contact Info

Product

Resources

About