Fungal endocarditis with central and peripheral embolization: Case report

Ribeiro, Sílvia; Gaspar, António; Assunção, António; Torres, José Pinheiro; Azevedo, Pedro; Basto, L; Pinho, Paulo; Correia, Adelino

doi:10.1016/j.repce.2011.12.016

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…In fact, two of our patients showed pericardial involvement, thrombi or fungal masses. 31,32 In conclusion, endomyocardial aspergillosis consists of a rare yet severe complication of IPA, is associated with very high mortality and carries many unknown modalities concerning its appropriate work-up and therapeutic management. More studies are required in order to gather the appropriate data to develop efficient diagnostic and therapeutic approaches in order to improve the disease outcome.…”

Section: Discussionmentioning

confidence: 99%

Endomyocardial and pericardial aspergillosis in critically ill patients

Dimοpoulos

Frantzeskaki

Kosmopoulos

et al. 2017

Mycoses

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Invasive aspergillosis(IA) is a potentially lethal complication of Aspergillus infection affecting mainly immunocompromised hosts; however, during the last two decades its incidence was increasingly observed in critically ill immunocompetent patients. The objective of this study is to describe the clinical characteristics of histologically proven endomyocardial and pericardial invasion, in the context of IA, in critically ill patients. Eight critically ill patients with histopathological confirmation of endomyocardial/pericardial aspergillosis were evaluated. Risk factors, clinical and laboratory characteristics, treatment, histopathological characteristics and mortality were recorded. Signs and symptoms of cardiac dysfunction were not observed in any of the patients. Therapy was administered to six of them shortly after the first positive culture. The observed histopathological lesions included haemorrhagic lesions, small vessels with central thrombosis and surrounding consolidated tissue with necrosis. Voriconazole, caspofungin, lipid amphotericin B and itraconazole were the used antifungals. The mortality rate was high (87.5%). Endomyocardial and pericardial aspergillosis are devastating complications of invasive aspergillosis. Clinical suspicion is low making the diagnosis difficult, therefore histopathological examination of tissues are required. The mortality is high.

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Section: Discussionmentioning

confidence: 99%

Endomyocardial and pericardial aspergillosis in critically ill patients

Dimοpoulos

Frantzeskaki

Kosmopoulos

et al. 2017

Mycoses

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Löeffler endocarditis due to idiopathic hypereosinophilic syndrome

Benchea

Clément

Nedelcu

et al. 2021

Romanian Journal of Cardiology

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Hypereosinophilic syndrome encompasses a heterogenous group of non-hematologic and hematologic disorders defined as peripheral blood eosinophilia >1500/mm3 persisting more than 6 months and eosinophilic end organ complications. Löeffl er endocarditis (LE) is the most common cardiac manifestation of the hypereosinophilic syndrome (HES) and represents an acute form of primary restrictive cardiomyopathy. We report the case of a 74 years-old woman with symptoms related to congestive heart failure and weight loss. At admission the patient had tachycardia and a grade 2/6 systolic mitral murmur. Laboratory findings revealed eosinophilia, hepatocytolysis syndrome and dyslipidemia. The electrocardiogram (ECG) showed non-specific ST-segment and T wave abnormalities. The echocardiography revealed left ventricular apical thrombus and entrapment of chordae tendineae with restricted motion of mitral leaflets leading to mitral regurgitation. The diagnosis of myocarditis was confirmed by the cardiac magnetic resonance imaging which showed the presence of a left ventricular mass with low signal on steady-state free precession imaging and diffuse circumferential subendocardial late gadolinium enhancement (LGE). When discussing the etiology of the HES the following were taken into consideration: hematologic, reactive or secondary disorders. This case is distinguished by diagnosis in an elderly woman and good response to corticosteroid therapy.

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Fungal endocarditis with central and peripheral embolization: Case report

Cited by 2 publications

References 7 publications

Endomyocardial and pericardial aspergillosis in critically ill patients

Endomyocardial and pericardial aspergillosis in critically ill patients

Löeffler endocarditis due to idiopathic hypereosinophilic syndrome

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