Fungal endophthalmitis (clinical case)

Терещенко, А.В.; Trifanenkova, I.G.; Okuneva, M.V.; Yudina, N.N.; Erohina, E.V.; Molotkova, I.A.; Prismotrova, E.V.

doi:10.25276/0235-4160-2019-2-70-75

Cited by 3 publications

(3 citation statements)

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“…Все это грибковое многообразие способно поражать практически любые отделы глаза и его придатков, упоминания о чем активно ведутся с 1960-х годов, вызывая микозы век [12], слезных органов [13], конъюнктивы [14], кератомикозы [15], микозы склеры [16] и сосудистой оболочки глаза [17] а также, конечно, грибковые эндофтальмиты [18].…”

Section: Research Justificationunclassified

“…При этом неплохую поддержку может оказать конфокальная микроскопия, позволяющая в некоторых случаях обнаружить грибковый мицелий в виде нитчатых структур в слоях пораженной роговицы [18].…”

Section: рис 3 фундус-снимок глазного дна с признаками кандидозногоunclassified

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Fungal Endophthalmitis. Literature Review

Казайкин

Ponomarev

2020

Oftalʹmologiâ

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Section: Research Justificationunclassified

Section: рис 3 фундус-снимок глазного дна с признаками кандидозногоunclassified

Fungal Endophthalmitis. Literature Review

Казайкин

Ponomarev

2020

Oftalʹmologiâ

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“…Чувствительная к вышеуказанным препаратам бактериальная и грибковая флора, как правило, успешно подвергается эрадикации с помощью вышеописанной технологии, однако встречаются случаи полной резистентности со стороны потенциальных возбудителей ЭФ к проводимой терапии [4][5][6].…”

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Evaluation of the Ophthalmotoxic Effect of Quantum Dots and Bioconjugates Based on Them in Terms of the Prospects for the Treatment of Resistant Endophthalmitis. Experimental Research (Stage 1)

et al. 2021

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Endophthalmitis remains one of the most formidable complications of surgery in ophthalmology, leading to significant functional and anatomical changes. The “gold” standard of treatment for this pathology is the installation of intravenous injections of antibacterial drugs, but taking into account the number and type of pathogens, the growth of antibiotic resistance, the search for alternative methods of treatment of endophthalmitis remains relevant. Colloidal quantum dots, which are nanoscale semiconductor crystals with simulated optical and electronic properties due to changes in their volume, composition, and surface connections, are of interest for research in this direction. This article presents the process of synthesis of CT and bioconjugates based on them in order to assess ophthalmotoxicity with the prospect of further use in the treatment of endophthalmitis. The study was divided into 4 stages, starting with the determination of the required technical specification in order to select the appropriate type of quantum dots taking into account the physical and chemical characteristics (Stage 1), the synthesis of quantum dots (Stage 2), the preparation and titration of a solution of quantum dots of various concentrations for implantation in the vitreous cavity (Stage 3). The final stage was to evaluate the toxic effect of the quantum dot solution in its pure form, as well as in combination with antibiotics (ceftazidime and vancomycin) when administered intravitreally on an animal model. As a result of the study, quantum dots were synthesized and a solution based on them was obtained for introduction into the vitreous cavity. Based on the testing of the animal model (rabbits), a safe dose of the solution was determined, as well as the possibility of its use in combination with antibiotics.

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Antifungal Macrocycle Antibiotic Amphotericin B—Its Present and Future. Multidisciplinary Perspective for the Use in the Medical Practice

Baghirova

Kasumov

2022

Biochem. Moscow Suppl. Ser. B

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This review is devoted to a broad analysis of the results of studies of the effect of macrocyclic antifungal polyene antibiotic amphotericin B on cell membranes. A detailed study of polyenes has shown that some of them can have not only antifungal, but also antiviral and antitumor effects. Under conditions of global pandemic fungal pathology develops especially quickly and in this case leads to invasive aspergillosis, which contributes to the complication of coronavirus infection in the lungs and even secondary infection with invasive aspergillosis. The treatment of an invasive form of bronchopulmonary aspergillosis is directly related to the immunomodulatory and immunostimulating properties of the macrocyclic polyene drug amphotericin B. The article presents experimental data on the study of the biological activity and membrane properties of amphotericin B and the effect of its chemically modified derivatives, as well as liposomal forms of amphotericin B on viral, bacterial and fungal infections. The mechanism of action of amphotericin B and its analogues is based on their interaction with cellular and lipid membranes, followed by formation of ion channels of molecular size in the membranes. The importance of these studies is that polyenes are sensitive to membranes that contain sterols of a certain structure. The analysis showed that pathogenic fungal cells containing ergosterol were 10−100 times more sensitive to polyene antibiotics than host cell membranes containing cholesterol. The high sterol selectivity of the action of polyenes opens broad prospects for the use of polyene antifungal drugs in practical medicine and pharmacology in the treatment of invasive mycoses and the prevention of atherosclerosis. In this context, it should be noted that polyene antibiotics are the main tool in the study of the biochemical mechanism of changes in the permeability of cell membranes for energydependent substrates. Chemical and genetic engineering transformation of the structure of polyene antibiotic molecules opens prospects for the identification and creation of new biologically active forms of the antibiotic that have a high selectivity of action in the treatment of pathogenic infections.

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Fungal endophthalmitis (clinical case)

Cited by 3 publications

References 0 publications

Fungal Endophthalmitis. Literature Review

Fungal Endophthalmitis. Literature Review

Evaluation of the Ophthalmotoxic Effect of Quantum Dots and Bioconjugates Based on Them in Terms of the Prospects for the Treatment of Resistant Endophthalmitis. Experimental Research (Stage 1)

Antifungal Macrocycle Antibiotic Amphotericin B—Its Present and Future. Multidisciplinary Perspective for the Use in the Medical Practice

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