Fungal keratitis caused byMetarhizium anisopliaevar.anisopliae

García, Mora; Arboleda, M.L.; Barraquer, Francisco; Grose, Elizabeth S.

doi:10.1080/02681219780001421

Cited by 49 publications

(16 citation statements)

References 4 publications

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“…Species and genera of fungi implicated as genuine ophthalmic pathogens in the past 5 years include Chrysosporium parvum (415), Metarhizium anisopliae var. anisopliae (76), Phaeoisaria clematidis (131), and Sarcopodium oculorum (132). In this review, no attempt has been made to list every single fungal genus or species implicated in ophthalmic infection, given the limitations listed above.…”

Section: Etiological Agents and Laboratory Diagnosis Of Ophthalmic Mymentioning

confidence: 99%

Current Perspectives on Ophthalmic Mycoses

2003

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Fungi may infect the cornea, orbit and other ocular structures. Species of Fusarium, Aspergillus, Candida, dematiaceous fungi, and Scedosporium predominate. Diagnosis is aided by recognition of typical clinical features and by direct microscopic detection of fungi in scrapes, biopsy specimens, and other samples. Culture confirms the diagnosis. Histopathological, immunohistochemical, or DNA-based tests may also be needed. Pathogenesis involves agent (invasiveness, toxigenicity) and host factors. Specific antifungal therapy is instituted as soon as the diagnosis is made. Amphotericin B by various routes is the mainstay of treatment for life-threatening and severe ophthalmic mycoses. Topical natamycin is usually the first choice for filamentous fungal keratitis, and topical amphotericin B is the first choice for yeast keratitis. Increasingly, the triazoles itraconazole and fluconazole are being evaluated as therapeutic options in ophthalmic mycoses. Medical therapy alone does not usually suffice for invasive fungal orbital infections, scleritis, and keratitis due to Fusarium spp., Lasiodiplodia theobromae, and Pythium insidiosum. Surgical debridement is essential in orbital infections, while various surgical procedures may be required for other infections not responding to medical therapy. Corticosteroids are contraindicated in most ophthalmic mycoses; therefore, other methods are being sought to control inflammatory tissue damage. Fungal infections following ophthalmic surgical procedures, in patients with AIDS, and due to use of various ocular biomaterials are unique subsets of ophthalmic mycoses. Future research needs to focus on the development of rapid, species-specific diagnostic aids, broad-spectrum fungicidal compounds that are active by various routes, and therapeutic modalities which curtail the harmful effects of fungus- and host tissue-derived factors

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Section: Etiological Agents and Laboratory Diagnosis Of Ophthalmic Mymentioning

confidence: 99%

Current Perspectives on Ophthalmic Mycoses

2003

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“…6,8 Two previous single case reports have suggested that topical natamycin is effective against M. anisopliae. 3,4 Systemic antifungals such as voriconazole may be an effective treatment for filamentous keratitis that is not responsive to topical treatment. 11 We elected to modify topical therapy instead of adding voriconazole because the infiltrate did not extend deeper than superficial stroma and no intraocular inflammation was present.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9] An 18-year-old Columbian man with a painless round M. anisopliae corneal ulcer was cured with topical natamycin 5% and silver-sulfadiazine 1%. 3 A 36-year-old American female contact lens wearer with mild eye irritation attributable to a 2.5 mm round paracentral M. anisopliae corneal ulcer was left with a stromal scar after a 2-month course of topical medications including natamycin 5% and multiple antibacterials. 4 A 52-year-old Australian woman presented with a painless red eye due to a 7 Â 4.5 mm M. anisopliae corneal ulcer and adjacent scleral necrosis.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Metarrhizium anisopliae keratitis

Motley

Melson

Mortensen

2011

Journal of American Association for Pediatric Ophthalmology and

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“…Also Strasser et al (2000) conclude from a risk-assessment study that the fungus poses no obvious risk to humans, or the environment. However, it has been reported that the fungus may cause human keratitis (DeGarcia et al 1997). Other work has shown that the fungus can cause significant mortality of shrimp, frog and fish embryos exposed to conidia (Genthner et al 1994(Genthner et al , 1998.…”

Section: Metarhiziummentioning

confidence: 98%

Coelomomyces numularius sp. nov. (Blastocladiales: Coelomomycetaceae), a New Fungal Parasite of Anopheles squamosus (Diptera: Culicidae) from Angola, Africa

Ribeiro

Ramos

2000

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Fungal keratitis caused byMetarhizium anisopliaevar.anisopliae

Cited by 49 publications

References 4 publications

Current Perspectives on Ophthalmic Mycoses

Current Perspectives on Ophthalmic Mycoses

Pediatric Metarrhizium anisopliae keratitis

<I>Coelomomyces numularius</I> sp. nov. (Blastocladiales: Coelomomycetaceae), a New Fungal Parasite of <I>Anopheles squamosus</I> (Diptera: Culicidae) from Angola, Africa

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