Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections?

Lönn‐Stensrud, Jessica; Landin, Maria A.; Benneche, T.; Petersen, Fernanda Cristina; Scheie, Anne Aamdal

doi:10.1093/jac/dkn501

Cited by 97 publications

(72 citation statements)

References 40 publications

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“…AI-2 signaling in Gram-positive bacteria is even less clear, since no signaling pathways have been described, yet staphylococcal biofilms were inhibited from growing on materials used in medical devices when furanone compounds were integrated into them (252). Likewise, synthetic furanones and furanone analogues incorporating thiophenone moieties decreased staphylococcal biofilm formation mediated by AI-2 (245,253). However, these reports are in conflict with findings that luxS mutants of Staphylococcus epidermidis display increased biofilm formation (254) and that furanones supplied at sub-MICs actually enhance biofilm development (255).…”

Section: Natural-product Qs Inhibitorsmentioning

confidence: 99%

“…Taking the data together, furanones appear not to inhibit LuxR activation by a "classic" competition mechanism, but rather they appear to engage LuxR at sites that are somewhat different from those used in AHL interactions and thus cause protein instability. Less is clear on how furanones interfere with AI-2-based signaling, though covalent modification of LuxS by C-2 has been implicated (147) (see "Inhibition of AI-2 Production" above) and may explain findings of reduced AI-2 production by this compound in some species (251,253). To date, no studies have investigated if AI-2-binding proteins are directly affected by furanones.…”

Section: Natural-product Qs Inhibitorsmentioning

confidence: 99%

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Exploiting Quorum Sensing To Confuse Bacterial Pathogens

LaSarre

Federle

2013

Microbiol Mol Biol Rev

693

556

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SUMMARY Cell-cell communication, or quorum sensing, is a widespread phenomenon in bacteria that is used to coordinate gene expression among local populations. Its use by bacterial pathogens to regulate genes that promote invasion, defense, and spread has been particularly well documented. With the ongoing emergence of antibiotic-resistant pathogens, there is a current need for development of alternative therapeutic strategies. An antivirulence approach by which quorum sensing is impeded has caught on as a viable means to manipulate bacterial processes, especially pathogenic traits that are harmful to human and animal health and agricultural productivity. The identification and development of chemical compounds and enzymes that facilitate quorum-sensing inhibition (QSI) by targeting signaling molecules, signal biogenesis, or signal detection are reviewed here. Overall, the evidence suggests that QSI therapy may be efficacious against some, but not necessarily all, bacterial pathogens, and several failures and ongoing concerns that may steer future studies in productive directions are discussed. Nevertheless, various QSI successes have rightfully perpetuated excitement surrounding new potential therapies, and this review highlights promising QSI leads in disrupting pathogenesis in both plants and animals.

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Section: Natural-product Qs Inhibitorsmentioning

confidence: 99%

Section: Natural-product Qs Inhibitorsmentioning

confidence: 99%

Exploiting Quorum Sensing To Confuse Bacterial Pathogens

LaSarre

Federle

2013

Microbiol Mol Biol Rev

693

556

View full text Add to dashboard Cite

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“…11 Many studies have been designed to evaluate the effects of halogenated furanones on eukaryotic cell viability, and there was few data reported the toxicity of halogenated furanones. 12,13 On the aforementioned basis, halogenated furanone compounds have been considered as potential and ideal antibacterial agents for medical device coating. 9,12 For the past decade, special attention has been paid to polymeric microsphere/nanoparticles (NPs) for their sustained-release effects.…”

Section: Introductionmentioning

confidence: 99%

“…12,13 On the aforementioned basis, halogenated furanone compounds have been considered as potential and ideal antibacterial agents for medical device coating. 9,12 For the past decade, special attention has been paid to polymeric microsphere/nanoparticles (NPs) for their sustained-release effects. 14,15 Poly(D, L-lactic acid) (PLA) has been widely developed as drug carrier, due to its desirable biocompatibility and biodegradability.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity and biological performance of a novel antibacterial coating containing a halogenated furanone compound loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

Cheng¹,

Zhao²,

Liu³

et al. 2015

IJN

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Titanium implants have been widely used for many medical applications, but bacterial infection after implant surgery remains one of the most common and intractable complications. To this end, long-term antibacterial ability of the implant surface is highly desirable to prevent implant-associated infection. In this study, a novel antibacterial coating containing a new antibacterial agent, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone loaded poly(L-lactic acid) nanoparticles, was fabricated on microarc-oxidized titanium for this purpose. The antibacterial coating produced a unique inhibition zone against Staphylococcus aureus throughout a 60-day study period, which is normally long enough to prevent the infection around implants in the early and intermediate stages. The antibacterial rate for adherent S. aureus was about 100% in the first 10 days and constantly remained over 90% in the following 20 days. Fluorescence staining of adherent S. aureus also confirmed the excellent antibacterial ability of the antibacterial coating. Moreover, in vitro experiments showed an enhanced osteoblast adhesion and proliferation on the antibacterial coating, and more notable cell spread was observed at the early stage. It is therefore concluded that the fabricated antibacterial coating, which exhibits relatively long-term antibacterial ability and excellent biological performance, is a potential and promising strategy to prevent implant-associated infection.

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“…25,26 Owing to their advantages, many researchers have suggested that halogenated furanone compounds would potentially be ideal antibacterial agents on implants for preventing biofilm infection. 27,28 However, there have been few relevant reports on how to use halogenated furanone compounds in implants until now.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

Cheng¹,

Wu²,

Gao³

et al. 2012

IJN

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Background: Dental implants have become increasingly common for the management of missing teeth. However, peri-implant infection remains a problem, is usually difficult to treat, and may lead eventually to dental implant failure. The aim of this study was to fabricate a novel antibacterial coating containing a halogenated furanone compound, ie, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone (BBF)-loaded poly(L-lactic acid) (PLLA) nanoparticles on microarc-oxidized titanium and to evaluate its release behavior in vitro. Methods: BBF-loaded PLLA nanoparticles were prepared using the emulsion solventevaporation method, and the antibacterial coating was fabricated by cross-linking BBF-loaded PLLA nanoparticles with gelatin on microarc-oxidized titanium. Results: The BBF-loaded PLLA nanoparticles had a small particle size (408 ± 14 nm), a low polydispersity index (0.140 ± 0.008), a high encapsulation efficiency (72.44% ± 1.27%), and a fine spherical shape with a smooth surface. The morphology of the fabricated antibacterial coating showed that the BBF-loaded PLLA nanoparticles were well distributed in the pores of the microarc oxidation coating, and were cross-linked with each other and the wall pores by gelatin. The release study indicated that the antibacterial coating could achieve sustained release of BBF for 60 days, with a slight initial burst release during the first 4 hours. Conclusion:The novel antibacterial coating fabricated in this study is a potentially promising method for prevention of early peri-implant infection.

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Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections?

Abstract: Furanones may inhibit biofilm formation through interference with quorum sensing and thus represent promising agents for protecting surfaces from being colonized by S. epidermidis.

Cited by 97 publications

References 40 publications

Exploiting Quorum Sensing To Confuse Bacterial Pathogens

Exploiting Quorum Sensing To Confuse Bacterial Pathogens

Antibacterial activity and biological performance of a novel antibacterial coating containing a halogenated furanone compound loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

Fabrication and in vitro release behavior of a novel antibacterial coating containing halogenated furanone-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

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