Further experience with quingestanol acetate as a postcoital oral contraceptive

Mischler, Terrence W.; Berman, Edel; Rubio, Boris; Larrañaga, Alfredo; Guiloff, E; Moggia, Angel V.

doi:10.1016/0010-7824(74)90013-4

Cited by 13 publications

(8 citation statements)

References 3 publications

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“…• Four trials evaluated postcoital use of LNG in one or more doses other than 0.75 mg (Echeverry 1974;Kesseru 1973;Schering 1978). • Six trials evaluated pericoital use of one or more hormones other than LNG (Cox 1968;Mischler 1974;Rubio 1970;Szontagh 1969;Zanartu 1974;Zanartu 1976). • One trial evaluated postcoital use of a di erent hormonal drug and a dose of LNG other than 0.75 mg .…”

Section: Results Of the Searchmentioning

confidence: 99%

“…Szontagh 1969 evaluated postcoital use of dienoestrol (an estrogen) in 10 women and dienoestrol combined with ethynodiol-diacetate in 20 other women. Rubio 1970 andMischler 1974 evaluated postcoital use of di erent doses of quingestanol acetate (a progestogen). These two reports included some overlapping data, which we included only once in this review.…”

Section: Hormones Other Than Lngmentioning

confidence: 99%

“…The results of 13 trials were published in peer-reviewed journals (Canzler 1984;Cox 1968;He 1991;Kesseru 1973;Kliment 1986;Mischler 1974;Rubio 1970;Taylor 2014;WHO 1987;WHO 2000;Zanartu 1974). The results of one study were published in a manuscript (Zanartu 1976).…”

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

“…Only 14 reports specified inclusion and exclusion criteria (Canzler 1984;Echeverry 1974;He 1991;Kesseru 1973;Klawe 1984;Mischler 1974;Nirapathpongporn;Rubio 1970;Seregely 1982;Taylor 2014;WHO 1987;WHO 2000;Zanartu 1974;Zanartu 1976). Some of these reports failed to define these criteria clearly; for instance, two studies included only 'fertile' women but did not explain how fertility was assessed.…”

Section: Other Potential Sources Of Biasmentioning

confidence: 99%

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Repeated use of pre- and postcoital hormonal contraception for prevention of pregnancy

Halpern

Raymond

Lopez

2014

Cochrane Database of Systematic Reviews

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The studies of pericoital LNG regimens provided promising results but many had serious methodological issues. Most reports were decades old and provided limited information. However, we considered the evidence to be moderate quality because of the large number of participants from diverse populations, the low pregnancy rates, and the consistent results across studies. Rigorous research is still needed to confirm the efficacy and safety of pericoital use of LNG as a primary means of contraception among women with infrequent intercourse. If the method is shown to be efficacious, safe and acceptable, the results may warrant revision of the current World Health Organization recommendations and marketing strategies.

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Section: Results Of the Searchmentioning

confidence: 99%

Section: Hormones Other Than Lngmentioning

confidence: 99%

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

Section: Other Potential Sources Of Biasmentioning

confidence: 99%

See 2 more Smart Citations

Repeated use of pre- and postcoital hormonal contraception for prevention of pregnancy

Halpern

Raymond

Lopez

2014

Cochrane Database of Systematic Reviews

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“…Evaluation of an ongoing method of postcoital contraception (administration following each coital exposure) has primarily been cafried out in South America. The two most frequently employed compounds include d-norgestrel and quingestanol acetate (10) . The major factor affecting failure rates appears to be the dosage of drug employed.…”

Section: Progestinsmentioning

confidence: 99%

Postcoital Contraception

Yuzpe

1979

International Journal of Gynecology & Obstetrics

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Yuzpe AA (Dept of Obstetrics and Gynecology, University of Western Ontario, London, Ontario, Canada). Postcoital contraception. Int J Gynaecol Obstet 16: 497–501, 1979 The evolution of postcoital contraception has led to the development of emergency measures to be used following a single unprotected act of intercourse and to ongoing methods, such as the administration of a contraceptive steroid agent following every coital exposure. In emergency situations, the most commonly employed hormonal steroids are the synthetic, conjugated and natural estrogens, administered in large doses for five days. Recently, a combination of an estrogen and a progestin has been employed for the same purpose. A copper‐bearing intrauterine device (IUD), inserted within seven days of coitus, has also been utilized with success. Progestins alone have been utilized as an ongoing method of postcoital contraception. Failure rates have been found to vary with the dosage, the specific progestin employed and the frequency of intercourse. The major role of postcoital contraception in the developed world appears to be as an emergency measure. Ease of availability, a high degree of efficacy and a low incidence of side effects are essential for patient and physician acceptance.

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Repeated use of pre- and postcoital hormonal contraception for prevention of pregnancy

Halpern¹,

Raymond²,

Lopez³

2010

Cochrane Database of Systematic Reviews

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The studies of pericoital LNG regimens provided promising results but had a number of serious methodological limitations. A pressing need exits to conduct a rigorous research to confirm the efficacy and safety of pericoital use of LNG as a primary means of contraception among women with infrequent intercourse. If the method is shown to be efficacious, safe and acceptable, the results may warrant revision of the current WHO recommendations and marketing strategies.

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Further experience with quingestanol acetate as a postcoital oral contraceptive

Cited by 13 publications

References 3 publications

Repeated use of pre- and postcoital hormonal contraception for prevention of pregnancy

Repeated use of pre- and postcoital hormonal contraception for prevention of pregnancy

Postcoital Contraception

Repeated use of pre- and postcoital hormonal contraception for prevention of pregnancy

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