Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures

Delgado, Daniel Ricardo; Peña, María Ángeles; Martínez, Fleming; Jouyban, Abolghasem; Acree, William E.

doi:10.15171/ps.2016.24

Cited by 49 publications

(21 citation statements)

References 34 publications

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“…For the fine chemical industry, the separation and purification of crude products is a very important section and understanding the solubility properties of pharmaceuticals is the primary prerequisite for designing refined sections, because these contribute to the purification of the drug substance, the design of the drug formulation, and further understanding of the dissolution mechanism of the drug. Because of this, systematically determining the solubility of drugs in pure solvents and binary mixed solvents is an indispensable link. − Although the addition of an organic solvent to water to increase the dissolution of solutes is not a new method, it is convenient to explore the mechanism of solubilization or solubilization of solutes in pure solvents and the preferential solvation effect mechanism of solutes in mixed solvents by this means. , …”

Section: Introductionmentioning

confidence: 99%

Solubility of Bifonazole in Four Binary Solvent Mixtures: Experimental Measurement and Thermodynamic Modeling

Zhang

Huang

2019

J. Chem. Eng. Data

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Methanol (n-propanol, isopropanol, and propylene glycol) and water were mixed in different proportions to form four mixed solvents, which were applied to dissolve bifonazole. The mole fraction of bifonazole was determined by the isothermal dissolution equilibrium technique within T = 278.15–318.15 K and P = 101.1 kPa under the condition that the dissolution system reached equilibrium. The increase in the ratio of organic solvent to water in the mixed solvents and temperature promoted the increase in the solubility of bifonazole. The solvent formed by mixing methanol and water in different proportions was most beneficial for the dissolution of bifonazole in all solution systems at the same percentage of organic solvent and the same temperature. Moreover, the calculated results of the Jouyban–Acree model, the van’t Hoff–Jouyban–Acree model and the modified Apelblat–Jouyban–Acree model are in good agreement with the solubility data of the experimentally measured bifonazole. The mole fraction calculated by the model is not completely consistent with the experimental result, and the maximum average relative deviation between them is 2.76%. The determination of the solubility data of the drug in the mixed solvent is of great value for the improvement of the physical and chemical information of the drug and the analysis of the thermodynamic properties.

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Section: Introductionmentioning

confidence: 99%

Solubility of Bifonazole in Four Binary Solvent Mixtures: Experimental Measurement and Thermodynamic Modeling

Zhang

Huang

2019

J. Chem. Eng. Data

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“…As it is well known, all these sorts of correlations and predicting models are required in the pharmaceutical and chemical industries to save time and money in the optimization of the solubilization and/or crystallization process designs. [12][13][14]…”

Section: A R T I C L E I N F Omentioning

confidence: 99%

Modelling the Preferential Solvation of Ferulic Acid in {2-Propanol (1) + Water (2)} Mixtures at 298.15 K

Jouyban¹,

Martínez²

2017

Pharm Sci

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“…The design of these dosage forms is based on a complete understanding of the mole fraction of the drug in the mixed solvent. Naturally, a detailed understanding of the influence of temperature and solvent composition on the dissolution of drugs is a top priority. − While studying the dissolution data, it is matched with the selection of a variety of classic models suitable for mixed solvents for calculation, and the comparison between the calculated value and the experiment assists in verifying the scientificity of the experimental data …”

Section: Introductionmentioning

confidence: 99%

Equilibrium Solubility Determination and Modeling of Thifensulfuron Methyl in Four Solvent Mixtures

Huang

Zhang

2021

J. Chem. Eng. Data

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This study used five pure solvents as raw materials and formed four sets of mixed solvents by mixing methanol, ethanol, n-propanol, and N,N-dimethyl formamide (DMF) in water. According to the principle of the isothermal static state, the reaction temperature was increased from 278.15 to 323.15 K at 5 K intervals. Under normal pressure (101.1 kPa) and at a constant the mole fraction of the solute, the equilibrium solubility of thifensulfuron methyl was obtained using high-performance liquid chromatography (HPLC). The influence of temperature on the solute cannot be ignored. Low to high amounts of thifensulfuron methyl are dissolved at low to high temperature. The difference was that the water content of the mixed solvent was repulsive to the dissolution of the solute. With the increase in the water content, the mole fraction of thifensulfuron methyl decreased. At any temperature, the same proportion of water was added to the four organic solvents. Compared with other solvents, the mixture of DMF and water had an absolute dissolution advantage. In addition, the Jouyban–Acree model, the van’t Hoff–Jouyban–Acree model, and the Apelblat–Jouyban–Acree model were used to calculate the solubility of thifensulfuron methyl. The obtained average relative deviations were lower than 1.51% for correlative studies. The acquisition of solubility helps to obtain solubility parameters, which is a measure of intermolecular forces. Solubility is required in the fields of recrystallization and fractional crystallization in the chemical industry and the synthesis and separation of compounds.

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Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures

Cited by 49 publications

References 34 publications

Solubility of Bifonazole in Four Binary Solvent Mixtures: Experimental Measurement and Thermodynamic Modeling

Solubility of Bifonazole in Four Binary Solvent Mixtures: Experimental Measurement and Thermodynamic Modeling

Modelling the Preferential Solvation of Ferulic Acid in {2-Propanol (1) + Water (2)} Mixtures at 298.15 K

Equilibrium Solubility Determination and Modeling of Thifensulfuron Methyl in Four Solvent Mixtures

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