Further observations on the reversibility of experimentally induced atherosclerosis in rabbits

Gupta, Pooja; Hd, Tandon; Ramalingaswami, V.

doi:10.1002/path.1711050402

Cited by 20 publications

(1 citation statement)

References 9 publications

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“…Reports vary between increase [17], little change [18], redistribution [19] and reduction [20] in aortic lipid content after stopping atherogenic diet. Early lesions seem to regress [21].…”

Section: Regression and Slowing Of Progression Of Atherosclerosis Witmentioning

confidence: 99%

Natural Products in Regression and Slowing of Progression of Atherosclerosis

Prasad

2010

CPB

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Many natural products, including vitamin E, garlic, purpurogallin, flaxseed and its components [secoisolariciresinol diglucoside (SDG) and flax lignan complex (FLC)] and resveratrol have been reported to suppress hypercholesterolemic atherosclerosis. It is known that all of the drugs that suppress the development of atherosclerosis do not regress and/or slow the progression of atherosclerosis. To be of potential benefit in patients with established atherosclerosis, a drug should produce regression and/or slow the progression of atherosclerosis. In this review, the effects of vitamin E, SDG and FLC in the regression and slowing of progression of hypercholesterolemic atherosclerosis and their mechanisms have been described. The effectiveness of vitamin E in patients with established coronary disease is very controversial. However, in experimental animal controlled studies, vitamin E does not regress or slow the progression of hypercholesterolemic atherosclerosis. The mechanisms of the ineffectiveness of vitamin E in regression and slowing of progression of atherosclerosis have been discussed. SDG is effective in slowing the progression of atherosclerosis and partially effective in regression of hypercholesterolemic atherosclerosis. These effects are associated with reduction in oxidative stress. FLC does not regress hypercholesterolemic atherosclerosis but slows the progression of hypercholesterolemic atherosclerosis. Slowing of progression is associated with reduction on oxidative stress. In conclusion, vitamin E does not regress or slow the progression of established atherosclerosis. SDG slows the progression and regresses established atherosclerosis. FLC does not regress but slows the progression of established atherosclerosis.

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“…Reports vary between increase [17], little change [18], redistribution [19] and reduction [20] in aortic lipid content after stopping atherogenic diet. Early lesions seem to regress [21].…”

Section: Regression and Slowing Of Progression Of Atherosclerosis Witmentioning

confidence: 99%