Further observations relating to the physiological activity of adenine compounds

Bennet, D. W.; Drury, A. N.

doi:10.1113/jphysiol.1931.sp002775

Cited by 122 publications

(35 citation statements)

References 9 publications

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“…Adenosine and certain related compounds cause relaxation of the smooth muscle in a number of structures including that in the gastrointestinal tract (Burnstock, 1972) and the coronary vasculature (Berne, 1964), and tracheal bronchial smooth muscle (Bennett & Drury, 1931;Florey & Wells, 1931;Lendle, 1937;Meves, 1953;Bianchi, de Natale & Giaquinto, 1963;Bertelli, Bianchi & Beani, 1973 (Kraupp, Heistracher, Wolner & Tuisl, 1964;Hilger, 1969;Kolassa et al, 1970;Buyniski et al, 1972;Sano et al, 1972) and dipyridamole and hexobendine to potentiate the negative chronotropic effect of adenosine on cardiac muscle (Hockerts & Bogelmann, 1959;Hopkins & Goldie, 1971;Kolassa, Pfleger & Trim, 1971). The mechanism of the potentiation of adenosine by these agents may involve inhibition of adenosine uptake since Pfleger, Volkmer & Kolassa (1969) and Hopkins (1973) (Stafford, 1966;Hulme & Weston, 1974) or portal vein (Hughes & Vane, 1970).…”

Section: Discussionmentioning

confidence: 99%

Effects of Some Purine Derivatives on the Guinea‐pig Trachea and Their Interaction With Drugs That Block Adenosine Uptake

Coleman¹

1976

British J Pharmacology

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I Adenosine, adenosine 5'-triphosphate (ATP), adenine, inosine and guanosine all caused concentration-dependent relaxations of guinea-pig tracheal smooth muscle in vitro. The relative potencies in descending order were: adenine > guanosine > inosine > adenosine > ATP 2 Responses to the purine compounds were unaffected by propranolol (1 jg/ml). 3 The spasmolytic potencies of adenosine and ATP were greatly enhanced in the presence of the adenosine uptake blocking drugs dipyridamole, hexobendine or Dilazep, whereas responses to adenine were unaffected and those to inosine and guanosine were reduced. 4 The spasmolytic potencies of noradrenaline, aminophylline, prostaglandin E2 and glyceryl trinitrate were unaffected by dipyridamole, hexobendine and Dilazep. 5 It is suggested that an adenosine uptake process may exist in the trachea of the guinea-pig and that this process is inhibited by dipyridamole, hexobendine and Dilazep.

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Section: Discussionmentioning

confidence: 99%

Effects of Some Purine Derivatives on the Guinea‐pig Trachea and Their Interaction With Drugs That Block Adenosine Uptake

Coleman¹

1976

British J Pharmacology

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“…Acetylcholine and histamine are also ruled out by the fact that root extracts are still effective after full doses of atropine and mepyramine. The chemical properties of the dilator substance also enable it to be distinguished from various other preparations: substance P (Gaddum & Schild, 1934), and the brain preparation of Major, Nanninga & Weber (1932) are soluble in acetone; kallikrein (Kraut, Frey & Werle, 1933;Werle, 1936) is heat labile; adenosine and its derivatives (Bennet & Drury, 1931) are resistant to boiling in alkaline solution; bradykinin is resistant to boiling in acid (Rocha e Silva, Beraldo & Rosenfeld, 1949); and necrosin (Menkin, 1943) is not dialysable.…”

Section: Resultsmentioning

confidence: 99%

The vasodilator activity of spinal roots

Holton¹,

Holton²

1952

The Journal of Physiology

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In 1935, Dale suggested that the identification of the chemical transmitter responsible for antidromic vasodilatation would be a useful approach to the problem of sensory transmission in the central nervous system since it is likely that the transmitter is the same at both ends of the sensory neurone. One of the difficulties in searching for the transmitter at central sensory endings is the lack of a specific pharmacological test for it. However, if the transmitter is also responsible for antidromic vasodilatation, it should be possible to detect it by its vasodilator activity in those organs in which antidromic vasodilatation can be elicited. This approach was used by Hellauer & Umrath (1947, 1948), who studied the effects of injecting extracts of dorsal and ventral roots into the rabbit's ear. As a result of their experiments they claim that: (1) dorsal roots contain a vasodilator substance which is neither acetylcholine nor histamine; this substance is absent from ventral roots; (2) sensory denervation increases the sensitivity of the rabbit's ear to the substance; (3) the vasodilator substance is enzymically destroyed when incubated for 20 hr, the enzyme activity being greatest in dorsal roots and less in ventral roots and preganglionic sympathetic fibres; (4) the enzyme is inhibited by strychnine.They conclude that the vasodilator substance is the transmitter liberated at sensory nerve endings.Since this claim is of far-reaching significance for the theory of central synaptic transmission we have repeated and extended their experiments and were able to confirm some, but not all, of their results. In our view, the eyidence now available is not sufficient to support the general conclusion of Hellauer & Umrath. METHODS Spinal root extract8Extracts were prepared from the spinal roots ofhorses which were dissected in the slaughter-house. The dissection was started about 25 min after the death of the animal and took 10 min for each horse. Starting at the last sacral segment, the ligamentum denticulatum was identified between * Beit Memorial Research Fellow.

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“…Adenosine and its compounds have been shown to be present in a large number of tissues. Some of their pharmacological effects have been studied by Drury and Szent-Gy6rgyi [1929], Bennet andDrury [1931], Zipf [1931], Ostern andParnas [1932], Deuticke [1932] and Drury [1932]. Zipf has drawn attention to the fact that they are probably responsible for those effects of defibrinated blood which Freund [1920] attributed to the "Friihgift.…”

Section: Vaso-motor Changes In Lungsmentioning

confidence: 99%

The localization of the action of drugs on the pulmonary vessels of dogs and cats

Gaddum¹,

Holtz²

1933

The Journal of Physiology

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SINCE previous studies of the effect of drugs on the pulmonary vessels have been reviewed by Wiggers [1921], Tigerstedt [1923] and Daly [1932], it is not necessary for us to present a connected historical survey.We will discuss earlier work only in so far as it bears directly on our own experiments, which were devised with the chief object of obtaining information regardingthe site of action on the pulmonary circulation of various pharmacologically active substances which are found in tissue extracts.In early work on this subject the assumption was usually made that any observed effects of drugs on the resistance of the pulmonary vessels to the flow of blood were due to an action on the pulmonary arterioles. The suggestion that changes in the tone of the pulmonary veins might appreciably affect the resistance originated partly from the study of the action of drugs on isolated veins [Inchley, 1923[Inchley, , 1926 Franklin, 1932, who gives other references], and partly from observations of the lung volume when the circulation was intact [Luisada, 1928;Mautner and Pick, 1929]. Mautner and Pick have shown that the blood flow through the portal system of the dog is much influenced by the resistance offered by the hepatic veins under the action of histamine, and they give evidence suggesting that histamine also causes the pulmonary veins to constrict.The conclusions of Mautner and Pick regarding the portal circulation have been confirmed and extended in an investigation carried out in this laboratory [Bauer, Dale, Poulsson and Richards, 1932]. The present work was undertaken with the object of applying similar methods to the study of the behaviour of the pulmonary vessels. It was hoped that fresh light might be thrown on the importance of the pulmonary veins by

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Further observations relating to the physiological activity of adenine compounds

Cited by 122 publications

References 9 publications

Effects of Some Purine Derivatives on the Guinea‐pig Trachea and Their Interaction With Drugs That Block Adenosine Uptake

Effects of Some Purine Derivatives on the Guinea‐pig Trachea and Their Interaction With Drugs That Block Adenosine Uptake

The vasodilator activity of spinal roots

The localization of the action of drugs on the pulmonary vessels of dogs and cats

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