Further Studies on the Concentration of the Antipellagra Factor

Koehn, C. J.; Elvehjem, C. A.

doi:10.1016/s0021-9258(18)74475-x

Cited by 43 publications

(3 citation statements)

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“…The association between NAD+ levels and health was initially established nearly a century ago by Elvehjem and his colleagues. In 1937, they discovered that pellagra resulted from a dietary insufficiency of niacin, resulting in reduced NAD+ levels [ 6 ]. Subsequent studies have demonstrated the correlation between low NAD+ levels and various disease conditions, such as metabolic disorders, neurodegenerative diseases, and aging [ 7 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of NAD+ metabolism on ovarian aging

Liang,

Huang,

Song

et al. 2023

Immun Ageing

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Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox reactions, is closely associated with age-related functional degeneration and metabolic diseases. NAD exerts direct and indirect influences on many crucial cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cellular senescence, and immune cell functionality. These cellular processes and functions are essential for maintaining tissue and metabolic homeostasis, as well as healthy aging. Causality has been elucidated between a decline in NAD levels and multiple age-related diseases, which has been confirmed by various strategies aimed at increasing NAD levels in the preclinical setting. Ovarian aging is recognized as a natural process characterized by a decline in follicle number and function, resulting in decreased estrogen production and menopause. In this regard, it is necessary to address the many factors involved in this complicated procedure, which could improve fertility in women of advanced maternal age. Concerning the decrease in NAD+ levels as ovarian aging progresses, promising and exciting results are presented for strategies using NAD+ precursors to promote NAD+ biosynthesis, which could substantially improve oocyte quality and alleviate ovarian aging. Hence, to acquire further insights into NAD+ metabolism and biology, this review aims to probe the factors affecting ovarian aging, the characteristics of NAD+ precursors, and the current research status of NAD+ supplementation in ovarian aging. Specifically, by gaining a comprehensive understanding of these aspects, we are optimistic about the prominent progress that will be made in both research and therapy related to ovarian aging.

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Section: Introductionmentioning

confidence: 99%

Impact of NAD+ metabolism on ovarian aging

Liang,

Huang,

Song

et al. 2023

Immun Ageing

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“…As the NA molecule is an important compound in biological processes, it is also linked to human health. In 1937, Koehn and Elvehjem discovered that NA may be applied in the treatment of pellagra disease (characterized by serious symptoms such as dermatitis, diarrhea, and dementia), 7 – from which the other name of NA originates (pellagra-preventive (PP) vitamin). This disease is caused by a lack of NA in the diet, which leads to insufficient levels of NAD + and NADP + in the body.…”

Section: Introductionmentioning

confidence: 99%

Negative ion formation and fragmentation upon dissociative electron attachment to the nicotinamide molecule

et al. 2021

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“…I In their most recent paperKoehn & Elvehjem [1937] have given the date of their 1936 paper as " 1935", which was the date of presentation.Biochem. 1937 XXXIr…”

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confidence: 99%

The vitamin B2 complex. Differentiation of the antiblacktongue and the P.-P. factors from lactoflavin and vitamin B6

Harris

1937

Biochemical Journal

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Further Studies on the Concentration of the Antipellagra Factor

Cited by 43 publications

References 10 publications

Impact of NAD+ metabolism on ovarian aging

Impact of NAD+ metabolism on ovarian aging

Negative ion formation and fragmentation upon dissociative electron attachment to the nicotinamide molecule

The vitamin B2 complex. Differentiation of the antiblacktongue and the P.-P. factors from lactoflavin and vitamin B6

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