Further study on Penares sp. from Vietnamese waters: Minor lanostane and nor-lanostane triterpenes

Achievements in the Study of Marine Low‐Molecular Weight Biologically Active Metabolites from the Vietnamese Territorial Waters as a Result of Expeditions aboard the Research Vessel ‘Akademik Oparin’ (2004–2017)

“…[29] Moreover, 14 new lanostane and nor-lanostane terpenoids 31-44 were isolated, together with the previously known related compounds penasterol (45), acetylpenasterol (46), penasterone (47), ergosta-4,24(28)-dien-3-one (48), and 24-ethylcholesta-4,24(28)-dien-3-one (49). [30,31] Compounds 31-34, 36, 38, 41 -44 contain the unique combination of a 30,9α-lactone and a 7β,8β-epoxide in their structures. The cytotoxic activities of compounds 31-36 and 46-48 against several cell lines (the mouse epidermal cell line JB6 Cl 41, murine Ehrlich carcinoma, HL-60, and HeLa) were investigated, and 3β-hydroxy-5α-lanosta-7,24-dien-30,9α-olide (36) was active against HL-60 cells with an IC 50 of 9.7 μM.…”

Triterpenoids

“…51 Compounds 169-176 are minor constituents of a Vietnamese Penares species. 52 The saponin 177, with a new hexanorlanostane genin, has been reported from the sponge Clathria gombawuiensis. 53 Lanostane saponins with known genins include eryloside W from Dictyonella marsilii, 54 saponins of the sea cucumber Cladolabes schmeltzii has been assigned as R. 59 Other holostane saponins with known genins include cercodemasoides A-E from Cercodemas anceps, 60 cucumarioside E from Cucumaria japonica 61 and moebioside A from Holothuria moebii.…”

Naturally occurring marine α,β‐epoxy steroids: Origin and biological activities

“…collected from the Vietnamese waters. [57] Three steroids (43)(44)(45) have been isolated from the gorgonian Acabaria undulata; the steroids possess a 7α,8α-epoxy-3β,5α,6α-trihydroxyl functionality as a common structural feature. The steroids exhibited moderate cytotoxicity and inhibitory activity against phospholipase A2.…”