Furunculosis Associated with Repeated Courses of Omeprazole Therapy

West, Burton C.; Agastya, Gautami; Sodeman, William A.; Callahan, Joyce M.

doi:10.1086/598353

Cited by 6 publications

(1 citation statement)

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“…It is possible that, in humans, if conversion of C difficile to the vegetative phase is occurring while the spores are still in the stomach, their survival may be facilitated by elevated gastric pH levels. Other mechanisms are also possible, such as gastrin-mediated direct effects on colonic mucosa, 33 effects on immune function, [12][13][14]34 or possibly effects on the organism's toxin production. Two studies did not find an association with gastric acid-suppressive use.…”

Section: Commentmentioning

confidence: 99%

Use of Gastric Acid–Suppressive Agents and the Risk of Community-Acquired <EMPH TYPE="ITAL">Clostridium difficile</EMPH>–Associated Disease

Dial

Delaney²,

Barkun³

et al. 2005

JAMA

876

509

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Section: Commentmentioning

confidence: 99%

Use of Gastric Acid–Suppressive Agents and the Risk of Community-Acquired <EMPH TYPE="ITAL">Clostridium difficile</EMPH>–Associated Disease

Dial

Delaney²,

Barkun³

et al. 2005

JAMA

876

509

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show abstract

Clinical Trials Report

Dial

Delaney²,

Barkun³

et al. 2006

Curr Gastroenterol Rep

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Acid-Suppressive Therapy and Risk of Infections: Pros and Cons

Fisher

2017

Clin Drug Investig

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This narrative review summarises the benefits, risks and appropriate use of acid-suppressing drugs (ASDs), proton pump inhibitors and histamine-2 receptor antagonists, advocating a rationale balanced and individualised approach aimed to minimise any serious adverse consequences. It focuses on current controversies on the potential of ASDs to contribute to infections-bacterial, parasitic, fungal, protozoan and viral, particularly in the elderly, comprehensively and critically discusses the growing body of observational literature linking ASD use to a variety of enteric, respiratory, skin and systemic infectious diseases and complications (Clostridium difficile diarrhoea, pneumonia, spontaneous bacterial peritonitis, septicaemia and other). The proposed pathogenic mechanisms of ASD-associated infections (related and unrelated to the inhibition of gastric acid secretion, alterations of the gut microbiome and immunity), and drug-drug interactions are also described. Both probiotics use and correcting vitamin D status may have a significant protective effect decreasing the incidence of ASD-associated infections, especially in the elderly. Despite the limitations of the existing data, the importance of individualised therapy and caution in long-term ASD use considering the balance of benefits and potential harms, factors that may predispose to and actions that may prevent/attenuate adverse effects is evident. A six-step practical algorithm for ASD therapy based on the best available evidence is presented.

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Furunculosis Associated with Repeated Courses of Omeprazole Therapy

Cited by 6 publications

References 0 publications

Use of Gastric Acid–Suppressive Agents and the Risk of Community-Acquired <EMPH TYPE="ITAL">Clostridium difficile</EMPH>–Associated Disease

Use of Gastric Acid–Suppressive Agents and the Risk of Community-Acquired <EMPH TYPE="ITAL">Clostridium difficile</EMPH>–Associated Disease

Clinical Trials Report

Acid-Suppressive Therapy and Risk of Infections: Pros and Cons

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