Fused Pyrimidines. Part 2. Synthesis and Antimicrobial Activity of Some Furo[3,2‐e]imidazo[1,2‐c]pyrimidines and Furo[2,3‐d]pyrimidines.

Abstract

Fused pyrimidine derivatives R 0515 Fused Pyrimidines. Part 2. Synthesis and Antimicrobial Activity of Some Furo[3,2-e]imidazo[1,2-c]pyrimidines and Furo[2,3-d]pyrimidines. -Various fused pyrimidines are synthesized starting from 2-amino-4,5-diphenylfuran-3-carbonitrile (I). They exhibit weak to moderate antibacterial and antifungal activities. -(BHUIYAN*, M. M. H.; RAHMAN, K. M. M.; HOSSAIN, M. K.; RAHIM, M. A.; HOSSAIN, M. I.; Croat. Chem. Acta 78 (2005) 4, 633-636; Dep. Chem., Univ. Chittagong, Chittagong 4331, Bangladesh; Eng.) -S. Adam 16-159

A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles

“…Furopyrimidine heterocyclic ring systems are structural analogues of purines which have been subjected to biological investigations to assess their potential therapeutic usefulness [ 67 ]. Furopyrimidines have attracted considerable attention because of their great practical potential as antiviral [ 68 , 69 , 70 ], antimicrobial [ 71 ] and antitumor agents [ 72 , 73 ]. Starting from commercially available 4-chlorofuro and thieno[3,2- d ]pyrimidine we obtained the same results, good to excellent yields (71% to 99%), for the desired compounds 15 to 24 under the same conditions ( Scheme 4 , Table 4 ).…”

Imidazo[1,2‐c]pyrimidin‐5(6H)‐one as a novel core of cyclin‐dependent kinase 2 inhibitors: Synthesis, activity measurement, docking, and quantum mechanical scoring

“…New kinase inhibitors are often developed by a multifaceted approach, including high‐throughput screening of compound libraries using biochemical/cellular assays or analogue synthesis. During our decade‐long research on kinase inhibitors, we have ascertained the importance of the heterocyclic core One less explored scaffold, imidazo[1,2‐ c ]pyrimidine, was previously investigated randomly for biological activities, such as antimicrobial, antimycobacterial, antitubercular, inotropic, antiinflammatory, analgesic, antipyretic, and ulcerogenic . Importantly, certain 5,7,8‐ and 2,5,8‐trisubstituted imidazo[1,2‐ c ]pyrimidine derivatives were described as potent Syk and Chk1 protein kinase inhibitors, respectively .…”

Synthesis of Substituted Thieno[2,3‐d]pyrimidin‐4‐ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models

“…ieno [2,3-d]pyrimidin-4-ones are a large group of heterocyclic compounds [1] and some of them show antiviral [2], antimicrobial [3][4][5][6][7][8][9][10], and antibacterial properties [11]. Fused tri-and tetracyclic thieno [2,3-d]pyrimidin-4-ones are synthesized by many methods and among them some compounds have fungicidal, antibacterial, and antiin�ammatory activities [12][13][14][15][16][17][18][19], and their substituted derivatives were reported as 17 -HSD1 inhibitors [20].…”